2. GPCR/G Protein
  3. GCGR
  4. Volagidemab

Volagidemab  (Synonyms: REMD-477; AMG-477)

Art. -Nr.: HY-P99383 Reinheit: ≥99.0%
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Volagidemab is an antagonistic glucagon receptor (GCGR) monoclonal antibody (mAb). Volagidemab can be used in the research of type 1 diabetes (T1D).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr. : 1233956-13-2

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Volagidemab Related Antibodies

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Beschreibung

Volagidemab is an antagonistic glucagon receptor (GCGR) monoclonal antibody (mAb). Volagidemab can be used in the research of type 1 diabetes (T1D)[1][2].

Isotype

Human IgG2 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

GCGR
In Vivo

Volagidemab (5 mg/kg, s.c.) suppresses type 1 diabetes phenotype in Alloxan-induced diabetic mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Alloxan-induced diabetic mice [2]
Dosage: 5 mg/kg
Administration: Subcutaneous injection (s.c.)
Result: Reduced phosphorylated CREB protein and PEPCK protein expression to nondiabetic levels.
Klinische Studie
Gene ID

2642  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molekulargewicht

147.02 kDa

CAS. Nr.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Volagidemab]
Versand

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG2 kappa
Biological Activity
  • Immobilized GCGR Protein, Human (HEK293, N-His, C-Myc, HY-P700411) can bind Volagidemab. The EC50 for this effect is 7.627 ng/mL.
Reinheit & Dokumentation
Verweise
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Volagidemab Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Volagidemab1233956-13-2REMD-477 AMG-477REMD477REMD 477AMG477AMG 477AMG-477GCGRGlucagon ReceptorType 1 diabetesT1DdiabetesInhibitorinhibitorinhibit

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