Zinc oxide, <100 nm particle size

Name: Zinc oxide, <100 nm particle size
Brand: MedChemExpress
SKU: HY-W116336D
Rating: 4.5 (0 reviews)

Cat. No.: HY-W116336D Assay: 99.28%: Ficha de datos
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Zinc oxide, <100 nm particle size is a nitrate reductase modulator and growth promoter with plant stress resistance activity and oral toxicity. Zinc oxide, <100 nm particle size acts as a nutrient source for maize plants. By enhancing nitrate reductase activity and reducing free proline levels, it significantly improves plant height, root length and dry matter weight of maize, and its growth-promoting effect is comparable to that of traditional zinc sulfate fertilizer. Zinc oxide, <100 nm particle size induces anemia-related and persistent tissue inflammatory damage, leading to obvious histopathological adverse reactions in the stomach, pancreas, eyes and prostate of rats. Zinc oxide, <100 nm particle size acts as a non-toxic antibacterial agent and selective cytotoxin against multiple bacteria, fungi and spores.

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Zinc oxide, <100 nm particle size Estructura química

No. CAS : 1314-13-2

Tamaño	Stock	Cantidad
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
500 mg	En stock	Estimated Time of Arrival: December 31
1 g	En stock	Estimated Time of Arrival: December 31
5 g	En stock	Estimated Time of Arrival: December 31
10 g	En stock	Estimated Time of Arrival: December 31
50 g	Obtener un presupuesto

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Descripciòn

In Vitro

Zinc oxide, <100 nm particle size (30 min dispersion; measured at 23°C for particle size, 25°C for zeta potential) has a zeta potential of -26.99 mV, agglomerates readily after dispersion, and maintains a <100 nm size as visualized via TEM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Zinc oxide, <100 nm particle size (0.05-0.5 ppm; in vitro nutrient solution; continuous exposure; 3 weeks) enhances maize plant growth, biomass production, nitrate reductase activity, and zinc accumulation in a dose-dependent manner, with the 0.5 ppm dose producing the greatest improvements^[1].
Repeated oral administration of <100 nm zinc oxide nanoparticles (both negatively and positively charged) (31.25-500 mg/kg; p.o.; daily/once daily, 7 days/week; 14-90 days) at doses ≥125 mg/kg for 90 days induces significant toxic effects in Sprague Dawley rats, with target organs including the stomach, pancreas, eye, and prostate gland, and a no observed adverse effect level (NOAEL) of 31.25 mg/kg for both sexes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Crl:CD(SD) rats (6-week-old, both sexes, 145.8-196.1 g, specific pathogen-free)^[2]
Dosage:	For 90-day DRF study: 500 mg/kg, 1000 mg/kg, 2000 mg/kg For 14-day DRF study: 31.25 mg/kg, 125 mg/kg, 500 mg/kg
Administration:	I:p.o.; daily; 14 days II: p.o.; once daily, 7 days/week; 90 days
Result:	Reported one death in the positively charged 1000 mg/kg group in the 14-day DRF study. Observed white feces, body weight loss, and corneal opacity across all doses in the 14-day DRF study. Noted histopathological lesions in the stomach and spleen in the 14-day DRF study. Recorded no mortality at any dose in the 90-day study. Observed sporadic salivation, white feces (consistent in 500 mg/kg groups), fur loss, and scarring across all doses in the 90-day study. Detected statistically significant, non-toxic feed and water consumption changes across doses in the 90-day study due to lack of dose dependency. Measured decreased hemoglobin, mean cell volume (MCV), mean cell hemoglobin (MCH), mean cell hemoglobin concentration (MCHC), hematocrit, and increased eosinophil counts in 500 mg/kg groups (both charges) in the 90-day study. Recorded decreased total erythrocyte count and prothrombin time in male 500 mg/kg groups, and increased total white blood cell and platelet counts in female 500 mg/kg groups in the 90-day study. Measured decreased total protein, albumin, and glucose; increased alkaline phosphatase, chloride, and inorganic phosphorus (males only) in 500 mg/kg groups (both charges) in the 90-day study. Recorded decreased total cholesterol and calcium, and increased creatine kinase in female 500 mg/kg groups in the 90-day study. Observed dose-dependent histopathological lesions at 500 mg/kg (some present at lower doses) including squamous cell hyperplasia/vacuolation (nonglandular stomach), intracytoplasmic hyaline droplets, submucosal edema/inflammation, eosinophilic chief cell/mucous cell hyperplasia (glandular stomach), acinar cell apoptosis/chronic inflammation (pancreas), retinal atrophy (eye), and suppurative inflammation (prostate gland, males) in the 90-day study. Measured increased submandibular gland weight (female 500 mg/kg negatively charged group), increased liver weight (female 500 mg/kg positively charged group), and increased relative adrenal gland weight/decreased absolute spleen weight (male 500 mg/kg positively charged recovery group) in the 90-day study.

Peso molecular

81.38

Fòrmula

ZnO

No. CAS

1314-13-2

Appearance

Solid

Color

White to off-white

SMILES

[Zn]=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Store at room temperature, keep dry and cool

In solvent	-80°C	1 year
	-20°C	6 months

Pureza y Documentación

Purity: 99.28%

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Ficha de datos (278 KB) SDS (458 KB)

COA (254 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Adhikari T, et al. Characterization of zinc oxide nano particles and their effect on growth of maize (Zea mays L.) plant[J]. Journal of Plant Nutrition, 2015, 38(10): 1505-1515.

[2]. Kim YR, et al. Toxicity of 100 nm zinc oxide nanoparticles: a report of 90-day repeated oral administration in Sprague Dawley rats. Int J Nanomedicine. 2014;9 Suppl 2(Suppl 2):109-126. Published 2014 Dec 15. [Content Brief]

[3]. Shamhari MN, et al. Synthesis and Characterization of Zinc Oxide Nanoparticles with Small Particle Size Distribution. Acta Chim Slov. 2018;65(3):578-585. [Content Brief]