2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid sodium

3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid sodium  (Synonyms: KDN sodium)

Cat. No.: HY-145533A Pureté: 95.0%
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3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid (KDN) sodium is a sialic acid. 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid sodium protects the oligo/(poly)sialyl chains from exosialidases at nonreducing terminal, and plays a role in egg activation of salmonid fish. 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid sodium is abundant in fetal cord red blood cells and malignant human ovarian cancer cells.

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3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid sodium

3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid sodium Chemical Structure

Size Prix Stock Quantité
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
5 mg En stock
10 mg En stock
25 mg En stock
50 mg En stock
100 mg En stock
200 mg   Obtenir un devis  
500 mg   Obtenir un devis  

* Veuillez sélectionner la quantité avant d'ajouter des articles.

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Other Forms of 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid sodium:

3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid sodium Related Antibodies

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Description

3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid (KDN) sodium is a sialic acid. 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid sodium protects the oligo/(poly)sialyl chains from exosialidases at nonreducing terminal, and plays a role in egg activation of salmonid fish. 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid sodium is abundant in fetal cord red blood cells and malignant human ovarian cancer cells[1][2].

Masse moléculaire

290.20

Formule

C9H15NaO9
Appearance

Solid

Color

White to off-white

SMILES

OC[C@@H](O)[C@H]([C@]1([H])OC(O)(C[C@@H]([C@H]1O)O)C(O[Na])=O)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvant et solubilité
In Vitro: 

DMSO : 50 mg/mL (172.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4459 mL 17.2295 mL 34.4590 mL
5 mM 0.6892 mL 3.4459 mL 6.8918 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (8.61 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (8.61 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4459 mL 17.2295 mL 34.4590 mL 86.1475 mL
5 mM 0.6892 mL 3.4459 mL 6.8918 mL 17.2295 mL
10 mM 0.3446 mL 1.7229 mL 3.4459 mL 8.6147 mL
15 mM 0.2297 mL 1.1486 mL 2.2973 mL 5.7432 mL
20 mM 0.1723 mL 0.8615 mL 1.7229 mL 4.3074 mL
25 mM 0.1378 mL 0.6892 mL 1.3784 mL 3.4459 mL
30 mM 0.1149 mL 0.5743 mL 1.1486 mL 2.8716 mL
40 mM 0.0861 mL 0.4307 mL 0.8615 mL 2.1537 mL
50 mM 0.0689 mL 0.3446 mL 0.6892 mL 1.7229 mL
60 mM 0.0574 mL 0.2872 mL 0.5743 mL 1.4358 mL
80 mM 0.0431 mL 0.2154 mL 0.4307 mL 1.0768 mL
100 mM 0.0345 mL 0.1723 mL 0.3446 mL 0.8615 mL
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3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid sodium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Deoxy-D-glycero-D-galacto-2-nonulosonic acidKDNEndogenous Metaboliteovarian cancerantigensalmonid fishInhibitorinhibitorinhibit

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3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid sodium
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