4,4'-Dihydroxybenzophenone

Name: 4,4'-Dihydroxybenzophenone
Brand: MedChemExpress
SKU: HY-W014226
Rating: 4.5 (0 reviews)

Cat. No.: HY-W014226 Pureza: 99.33%: Ficha de datos
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4,4'-Dihydroxybenzophenone is a type of phenolic ultraviolet absorber and a drug intermediate for synthesis of various anticancer active compounds (such as Sivifene (HY-14801)). 4,4'-Dihydroxybenzophenone binds to the active site of trypsin with binding constants (K_A = 7.59 x 10⁵ L/moL) and leads to abnormal structure of trypsin, suggesting that long-term intake may affect the digestive function of the human body. 4,4’-dihydroxybenzophenone has a relatively low toxicity to Chlorella vulgaris and a moderate toxicity to Daphnia magna.

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4,4'-Dihydroxybenzophenone Estructura química

No. CAS : 611-99-4

Tamaño	Stock	Cantidad

Muestra gratis (0.1 - 0.2 mg)	Solicite ahora
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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
500 g	En stock	Estimated Time of Arrival: December 31
> 100 g	Obtener un presupuesto

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Based on 1 Customer Validation

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Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
Peritoneal macrophage cell	CC₅₀	> 160 μg/mL Compound: 3	Cytotoxicity against mouse peritoneal macrophages after 72 hrs by MTT assay Cytotoxicity against mouse peritoneal macrophages after 72 hrs by MTT assay	[PMID: 23623672]

In Vitro

4,4'-Dihydroxybenzophenone (160-200 mg/L, 96 h) shows toxicity with an EC₅₀ value of 183.60 mg/L against Chlorella vulgaris, and this concentration falls under the low-level toxicity category^[1].
4,4'-Dihydroxybenzophenone (4-26 mg/L, 48 h) shows toxicity with an EC₅₀ value of 12.50 mg/L against Daphnia magna, and this concentration falls under the medium-level toxicity category^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

214.22

Fòrmula

C₁₃H₁₀O₃

No. CAS

611-99-4

Appearance

Solid

Color

White to yellow

SMILES

C2=C(C(C1=CC=C(O)C=C1)=O)C=CC(=C2)O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (466.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.6681 mL	23.3405 mL	46.6810 mL
5 mM	0.9336 mL	4.6681 mL	9.3362 mL
10 mM	0.4668 mL	2.3340 mL	4.6681 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.82%

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Ficha de datos (271 KB) SDS (393 KB)

COA (245 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Han J, et al. Acute toxicity and ecological risk assessment of 4,4'-dihydroxybenzophenone, 2,4,4'-trihydroxybenzophenone and 4-MBC in ultraviolet (UV)-filters. PLoS One. 2021 Apr 8;16(4):e0249915. [Content Brief]

[2]. Ma J, et al. Health risks posed by environmental benzophenone-type ultraviolet filters (BP-UVFs): An investigation into the binding of BP-UVFs to trypsin and their adverse effects. J Hazard Mater. 2023 Oct 5;459:132231. [Content Brief]

[3]. Morgan LR, et al. Design, synthesis, and anticancer properties of 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone and analogues. J Med Chem. 2003 Oct 9;46(21):4552-63. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.6681 mL	23.3405 mL	46.6810 mL	116.7025 mL
	5 mM	0.9336 mL	4.6681 mL	9.3362 mL	23.3405 mL
	10 mM	0.4668 mL	2.3340 mL	4.6681 mL	11.6702 mL
	15 mM	0.3112 mL	1.5560 mL	3.1121 mL	7.7802 mL
	20 mM	0.2334 mL	1.1670 mL	2.3340 mL	5.8351 mL
	25 mM	0.1867 mL	0.9336 mL	1.8672 mL	4.6681 mL
	30 mM	0.1556 mL	0.7780 mL	1.5560 mL	3.8901 mL
	40 mM	0.1167 mL	0.5835 mL	1.1670 mL	2.9176 mL
	50 mM	0.0934 mL	0.4668 mL	0.9336 mL	2.3340 mL
	60 mM	0.0778 mL	0.3890 mL	0.7780 mL	1.9450 mL
	80 mM	0.0584 mL	0.2918 mL	0.5835 mL	1.4588 mL
	100 mM	0.0467 mL	0.2334 mL	0.4668 mL	1.1670 mL