611-99-4
Chemical Structure
4,4'-Dihydroxybenzophenone
- CAS No.: 611-99-4
- Formula:C13H10O3
- Molecular Weight:214.22
IUPAC Name: 4,4'-Dihydroxybenzophenone
InChIKey: RXNYJUSEXLAVNQ-UHFFFAOYSA-N
SMILES: C2=C(C(C1=CC=C(O)C=C1)=O)C=CC(=C2)O
Biological Activity: 4,4'-Dihydroxybenzophenone is a type of phenolic ultraviolet absorber and a drug intermediate for synthesis of various anticancer active compounds (such as Sivifene (HY-14801)). 4,4'-Dihydroxybenzophenone binds to the active site of trypsin with binding constants (KA = 7.59 x 105 L/moL) and leads to abnormal structure of trypsin, suggesting that long-term intake may affect the digestive function of the human body. 4,4’-dihydroxybenzophenone has a relatively low toxicity to Chlorella vulgaris and a moderate toxicity to Daphnia magna[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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4,4'-Dihydroxybenzophenone | 99.33% | 4,4'-Dihydroxybenzophenone is a type of phenolic ultraviolet absorber and a drug intermediate for synthesis of various anticancer active compounds (such as Sivifene (HY-14801)). 4,4'-Dihydroxybenzophenone binds to the active site of trypsin with binding constants (KA = 7.59 x 105 L/moL) and leads to abnormal structure of trypsin, suggesting that long-term intake may affect the digestive function of the human body. 4,4’-dihydroxybenzophenone has a relatively low toxicity to Chlorella vulgaris and a moderate toxicity to Daphnia magna. | ||||||||||||||||||||
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- [1]. Han J, et al. Acute toxicity and ecological risk assessment of 4,4'-dihydroxybenzophenone, 2,4,4'-trihydroxybenzophenone and 4-MBC in ultraviolet (UV)-filters. PLoS One. 2021 Apr 8;16(4):e0249915. [Content Brief]
- [2]. Ma J, et al. Health risks posed by environmental benzophenone-type ultraviolet filters (BP-UVFs): An investigation into the binding of BP-UVFs to trypsin and their adverse effects. J Hazard Mater. 2023 Oct 5;459:132231. [Content Brief]
- [3]. Morgan LR, et al. Design, synthesis, and anticancer properties of 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone and analogues. J Med Chem. 2003 Oct 9;46(21):4552-63. [Content Brief]
Keywords
