4-Demethyldeoxypodophyllotoxin

Cat. No.: HY-N10829 Purity: 99.87%: Data Sheet
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4-Demethyldeoxypodophyllotoxin is an aryltetralin lignan that can be found in Podophyllum peltatum.

For research use only. We do not sell to patients.

4-Demethyldeoxypodophyllotoxin Chemical Structure

CAS No. : 3590-93-0

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

4-Demethyldeoxypodophyllotoxin is an aryltetralin lignan that can be found in Podophyllum peltatum^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	ED₅₀	0.08 μg/mL Compound: 6	Cytotoxicity against human A431 cells Cytotoxicity against human A431 cells	[PMID: 8277312]
A549	ED₅₀	0.023 μg/mL Compound: DDPT	Cytotoxicity in A549 (human carcinoma) cell line. Cytotoxicity in A549 (human carcinoma) cell line.	[PMID: 12873481]
A549	ED₅₀	15 nM Compound: DDPT (2)	In vitro cytotoxicity against A549 (human lung carcinoma) cell line. In vitro cytotoxicity against A549 (human lung carcinoma) cell line.	[PMID: 12419378]
A549	IC₅₀	0.8 μM Compound: 3, DDPT	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 20071056]
A549	IC₅₀	1.8 μM Compound: 13, DDPT	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 22244588]
A549	IC₅₀	1.8 μM Compound: 9, DDPT	Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 22041063]
A549	IC₅₀	3.75 μM Compound: 3, DDPT	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 21733601]
A549	IC₅₀	3.9 μM Compound: DDPT; 6	Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26873416]
CCRF S-180	IC₅₀	0.03 μM Compound: DDPT	Cytotoxicity in S-180 (murine sarcoma) cell was determined. Cytotoxicity in S-180 (murine sarcoma) cell was determined.	[PMID: 12873481]
CCRF S-180	IC₅₀	2 μM Compound: DDPT	Inhibition of tubulin polymerization in S180 (murine sarcoma) cells. Inhibition of tubulin polymerization in S180 (murine sarcoma) cells.	[PMID: 12873481]
CCRF S-180	IC₅₀	24.5 μM Compound: DDPT	Inhibition of DNA topoisomerase II in S180 (murine sarcoma) cells. Inhibition of DNA topoisomerase II in S180 (murine sarcoma) cells.	[PMID: 12873481]
Col2	ED₅₀	0.03 μg/mL Compound: 6	Cytotoxicity against human Col2 cells Cytotoxicity against human Col2 cells	[PMID: 8277312]
HCT-8	IC₅₀	9.81 μM Compound: DDPT; 6	Cytotoxicity against human HCT8 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HCT8 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26873416]
HL-60	IC₅₀	0.11 μM Compound: 3, DDPT	Cytotoxicity against human HL60 cells after 72 hrs by CCK8 method Cytotoxicity against human HL60 cells after 72 hrs by CCK8 method	[PMID: 20071056]
HL-60	IC₅₀	2.96 μM Compound: 13, DDPT	Cytotoxicity against human HL60 cells after 48 hrs by CCK-8 assay Cytotoxicity against human HL60 cells after 48 hrs by CCK-8 assay	[PMID: 22244588]
HL-60	IC₅₀	2.96 μM Compound: 9, DDPT	Cytotoxicity against human HL60 cells assessed as growth inhibition after 48 hrs by CCK-8 assay Cytotoxicity against human HL60 cells assessed as growth inhibition after 48 hrs by CCK-8 assay	[PMID: 22041063]
HT	ED₅₀	0.01 μg/mL Compound: 6	Cytotoxicity against human HT cells Cytotoxicity against human HT cells	[PMID: 8277312]
HeLa	IC₅₀	0.074 μM Compound: 8	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 21570846]
HeLa	IC₅₀	43 μM Compound: 9, DDPT	Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by CCK-8 assay Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by CCK-8 assay	[PMID: 22041063]
HeLa	IC₅₀	53.3 μM Compound: 13, DDPT	Cytotoxicity against human HeLa cells after 48 hrs by CCK-8 assay Cytotoxicity against human HeLa cells after 48 hrs by CCK-8 assay	[PMID: 22244588]
HeLa	IC₅₀	53.3 μM Compound: DDPT; 6	Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26873416]
HeLa	IC₅₀	7.43 μM Compound: 3, DDPT	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 21733601]
HepG2	IC₅₀	16.53 μM Compound: DDPT; 6	Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26873416]
KB	ED₅₀	0.01 μg/mL Compound: 6	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 8277312]
KB	IC₅₀	0.0078 μM Compound: 8	Cytotoxicity against human KB cells after 72 hrs by MTT assay Cytotoxicity against human KB cells after 72 hrs by MTT assay	[PMID: 21570846]
KB-V1	ED₅₀	0.02 μg/mL Compound: 6	Cytotoxicity against human KBV1 cells Cytotoxicity against human KBV1 cells	[PMID: 8277312]
LNCaP	ED₅₀	0.02 μg/mL Compound: 6	Cytotoxicity against human LNCAP cells Cytotoxicity against human LNCAP cells	[PMID: 8277312]
LNCaP	IC₅₀	0.15 μM Compound: 5	Cytotoxicity against androgen sensitive human LNCaP cells Cytotoxicity against androgen sensitive human LNCaP cells	[PMID: 17256902]
Lu1	ED₅₀	0.03 μg/mL Compound: 6	Cytotoxicity against human Lu1 cells Cytotoxicity against human Lu1 cells	[PMID: 8277312]
MCF7	ED₅₀	18 nM Compound: DDPT (2)	In vitro cytotoxicity against MCF-7 (human breast carcinoma) cell line. In vitro cytotoxicity against MCF-7 (human breast carcinoma) cell line.	[PMID: 12419378]
P388	ED₅₀	0.005 μg/mL Compound: 6	Cytotoxicity in mouse P388 cells Cytotoxicity in mouse P388 cells	[PMID: 8277312]
PC-3	IC₅₀	0.14 μM Compound: 5	Cytotoxicity against androgen-independent human PC3 cells Cytotoxicity against androgen-independent human PC3 cells	[PMID: 17256902]
RPMI-8226	IC₅₀	0.23 μM Compound: 3, DDPT	Cytotoxicity against human RPMI8226 cells after 72 hrs by CCK8 method Cytotoxicity against human RPMI8226 cells after 72 hrs by CCK8 method	[PMID: 20071056]
SK-MEL-2	ED₅₀	0.015 μg/mL Compound: DDPT	Cytotoxicity in SK-MEL-2 (human melanoma) cell line. Cytotoxicity in SK-MEL-2 (human melanoma) cell line.	[PMID: 12873481]
SK-MEL-2	ED₅₀	12 nM Compound: DDPT (2)	In vitro cytotoxicity against SK-MEL-2 (human melanoma) cell line. In vitro cytotoxicity against SK-MEL-2 (human melanoma) cell line.	[PMID: 12419378]
SiHa	IC₅₀	2.07 μM Compound: 3, DDPT	Cytotoxicity against human SiHa cells after 48 hrs by MTT assay Cytotoxicity against human SiHa cells after 48 hrs by MTT assay	[PMID: 21733601]
SiHa	IC₅₀	43 μM Compound: 13, DDPT	Cytotoxicity against human SiHa cells after 48 hrs by MTT assay Cytotoxicity against human SiHa cells after 48 hrs by MTT assay	[PMID: 22244588]
SiHa	IC₅₀	53.3 μM Compound: 9, DDPT	Cytotoxicity against human SiHa cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human SiHa cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 22041063]
U-373MG ATCC	ED₅₀	0.1 μg/mL Compound: 6	Cytotoxicity against human U373 cells Cytotoxicity against human U373 cells	[PMID: 8277312]
WI-38	IC₅₀	78.52 μM Compound: DDPT; 6	Cytotoxicity against human WI38 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human WI38 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26873416]
ZR-75-1	ED₅₀	2.1 μg/mL Compound: 6	Cytotoxicity against human ZR-75-1 cells Cytotoxicity against human ZR-75-1 cells	[PMID: 8277312]

Molecular Weight

384.38

Formula

C₂₁H₂₀O₇

CAS No.

3590-93-0

Appearance

Solid

Color

White to off-white

SMILES

O=C1[C@]2([H])[C@H](C3=CC(OC)=C(C(OC)=C3)O)C4=CC(OCO5)=C5C=C4C[C@@]2([H])CO1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Purity: 99.87%

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Data Sheet (276 KB) SDS (252 KB)

COA (263 KB) HNMR (125 KB) CNMR (115 KB) RP-HPLC (265 KB) MS (466 KB)

Handling Instructions (2659 KB)

References

[1]. David E.Jackson, et al. Aryltetralin lignans from Podophyllum hexandrum and Podophyllum peltatum. Phytochemistry. 1984, 23 (5): 1147-1152.