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Cat. No.: HY-N10829

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4-Demethyldeoxypodophyllotoxin

Name: 4-Demethyldeoxypodophyllotoxin
Brand: MedChemExpress
SKU: HY-N10829
Price: 120.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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4-Demethyldeoxypodophyllotoxin is an aryltetralin lignan that can be found in Podophyllum peltatum.

For research use only. We do not sell to patients.

Purity: 99.87%
CAS No.: 3590-93-0
Formula: C₂₁H₂₀O₇
Molecular Weight:384.38

Storage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

4-Demethyldeoxypodophyllotoxin Chemical Structure

CAS No.: 3590-93-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

4-Demethyldeoxypodophyllotoxin is an aryltetralin lignan that can be found in Podophyllum peltatum^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	ED₅₀	0.08 μg/mL Compound: 6	Cytotoxicity against human A431 cells Cytotoxicity against human A431 cells	[PMID: 8277312]
A549	ED₅₀	0.023 μg/mL Compound: DDPT	Cytotoxicity in A549 (human carcinoma) cell line. Cytotoxicity in A549 (human carcinoma) cell line.	[PMID: 12873481]
A549	ED₅₀	15 nM Compound: DDPT (2)	In vitro cytotoxicity against A549 (human lung carcinoma) cell line. In vitro cytotoxicity against A549 (human lung carcinoma) cell line.	[PMID: 12419378]
A549	IC₅₀	0.8 μM Compound: 3, DDPT	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 20071056]
A549	IC₅₀	1.8 μM Compound: 13, DDPT	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 22244588]
A549	IC₅₀	1.8 μM Compound: 9, DDPT	Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 22041063]
A549	IC₅₀	3.75 μM Compound: 3, DDPT	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 21733601]
A549	IC₅₀	3.9 μM Compound: DDPT; 6	Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26873416]
BC1 cell line	ED₅₀	0.01 μg/mL Compound: 6	Cytotoxicity against human BC1 cells Cytotoxicity against human BC1 cells	[PMID: 8277312]
CCRF S-180	IC₅₀	0.03 μM Compound: DDPT	Cytotoxicity in S-180 (murine sarcoma) cell was determined. Cytotoxicity in S-180 (murine sarcoma) cell was determined.	[PMID: 12873481]
CCRF S-180	IC₅₀	2 μM Compound: DDPT	Inhibition of tubulin polymerization in S180 (murine sarcoma) cells. Inhibition of tubulin polymerization in S180 (murine sarcoma) cells.	[PMID: 12873481]
CCRF S-180	IC₅₀	24.5 μM Compound: DDPT	Inhibition of DNA topoisomerase II in S180 (murine sarcoma) cells. Inhibition of DNA topoisomerase II in S180 (murine sarcoma) cells.	[PMID: 12873481]
Col2	ED₅₀	0.03 μg/mL Compound: 6	Cytotoxicity against human Col2 cells Cytotoxicity against human Col2 cells	[PMID: 8277312]
HCT-8	IC₅₀	9.81 μM Compound: DDPT; 6	Cytotoxicity against human HCT8 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HCT8 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26873416]
HeLa	IC₅₀	0.074 μM Compound: 8	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 21570846]
HeLa	IC₅₀	43 μM Compound: 9, DDPT	Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by CCK-8 assay Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by CCK-8 assay	[PMID: 22041063]
HeLa	IC₅₀	53.3 μM Compound: 13, DDPT	Cytotoxicity against human HeLa cells after 48 hrs by CCK-8 assay Cytotoxicity against human HeLa cells after 48 hrs by CCK-8 assay	[PMID: 22244588]
HeLa	IC₅₀	53.3 μM Compound: DDPT; 6	Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26873416]
HeLa	IC₅₀	7.43 μM Compound: 3, DDPT	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 21733601]
HepG2	IC₅₀	16.53 μM Compound: DDPT; 6	Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26873416]
HL-60	IC₅₀	0.11 μM Compound: 3, DDPT	Cytotoxicity against human HL60 cells after 72 hrs by CCK8 method Cytotoxicity against human HL60 cells after 72 hrs by CCK8 method	[PMID: 20071056]
HL-60	IC₅₀	2.96 μM Compound: 13, DDPT	Cytotoxicity against human HL60 cells after 48 hrs by CCK-8 assay Cytotoxicity against human HL60 cells after 48 hrs by CCK-8 assay	[PMID: 22244588]
HL-60	IC₅₀	2.96 μM Compound: 9, DDPT	Cytotoxicity against human HL60 cells assessed as growth inhibition after 48 hrs by CCK-8 assay Cytotoxicity against human HL60 cells assessed as growth inhibition after 48 hrs by CCK-8 assay	[PMID: 22041063]
HT	ED₅₀	0.01 μg/mL Compound: 6	Cytotoxicity against human HT cells Cytotoxicity against human HT cells	[PMID: 8277312]
KB	ED₅₀	0.01 μg/mL Compound: 6	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 8277312]
KB	IC₅₀	0.0078 μM Compound: 8	Cytotoxicity against human KB cells after 72 hrs by MTT assay Cytotoxicity against human KB cells after 72 hrs by MTT assay	[PMID: 21570846]
KB-V1	ED₅₀	0.02 μg/mL Compound: 6	Cytotoxicity against human KBV1 cells Cytotoxicity against human KBV1 cells	[PMID: 8277312]
LNCaP	ED₅₀	0.02 μg/mL Compound: 6	Cytotoxicity against human LNCAP cells Cytotoxicity against human LNCAP cells	[PMID: 8277312]
LNCaP	IC₅₀	0.15 μM Compound: 5	Cytotoxicity against androgen sensitive human LNCaP cells Cytotoxicity against androgen sensitive human LNCaP cells	[PMID: 17256902]
Lu1	ED₅₀	0.03 μg/mL Compound: 6	Cytotoxicity against human Lu1 cells Cytotoxicity against human Lu1 cells	[PMID: 8277312]
MCF7	ED₅₀	18 nM Compound: DDPT (2)	In vitro cytotoxicity against MCF-7 (human breast carcinoma) cell line. In vitro cytotoxicity against MCF-7 (human breast carcinoma) cell line.	[PMID: 12419378]
P388	ED₅₀	0.005 μg/mL Compound: 6	Cytotoxicity in mouse P388 cells Cytotoxicity in mouse P388 cells	[PMID: 8277312]
PC-3	IC₅₀	0.14 μM Compound: 5	Cytotoxicity against androgen-independent human PC3 cells Cytotoxicity against androgen-independent human PC3 cells	[PMID: 17256902]
RPMI-8226	IC₅₀	0.23 μM Compound: 3, DDPT	Cytotoxicity against human RPMI8226 cells after 72 hrs by CCK8 method Cytotoxicity against human RPMI8226 cells after 72 hrs by CCK8 method	[PMID: 20071056]
SiHa	IC₅₀	2.07 μM Compound: 3, DDPT	Cytotoxicity against human SiHa cells after 48 hrs by MTT assay Cytotoxicity against human SiHa cells after 48 hrs by MTT assay	[PMID: 21733601]
SiHa	IC₅₀	43 μM Compound: 13, DDPT	Cytotoxicity against human SiHa cells after 48 hrs by MTT assay Cytotoxicity against human SiHa cells after 48 hrs by MTT assay	[PMID: 22244588]
SiHa	IC₅₀	53.3 μM Compound: 9, DDPT	Cytotoxicity against human SiHa cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human SiHa cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 22041063]
SK-MEL-2	ED₅₀	0.015 μg/mL Compound: DDPT	Cytotoxicity in SK-MEL-2 (human melanoma) cell line. Cytotoxicity in SK-MEL-2 (human melanoma) cell line.	[PMID: 12873481]
SK-MEL-2	ED₅₀	12 nM Compound: DDPT (2)	In vitro cytotoxicity against SK-MEL-2 (human melanoma) cell line. In vitro cytotoxicity against SK-MEL-2 (human melanoma) cell line.	[PMID: 12419378]
U-373MG ATCC	ED₅₀	0.1 μg/mL Compound: 6	Cytotoxicity against human U373 cells Cytotoxicity against human U373 cells	[PMID: 8277312]
WI-38	IC₅₀	78.52 μM Compound: DDPT; 6	Cytotoxicity against human WI38 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human WI38 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26873416]
ZR-75-1	ED₅₀	2.1 μg/mL Compound: 6	Cytotoxicity against human ZR-75-1 cells Cytotoxicity against human ZR-75-1 cells	[PMID: 8277312]

Chemical Information

CAS No. 3590-93-0
Appearance Solid
Molecular Weight 384.38
Formula C₂₁H₂₀O₇
Color White to off-white
SMILES

O=C1[C@]2([H])[C@H](C3=CC(OC)=C(C(OC)=C3)O)C4=CC(OCO5)=C5C=C4C[C@@]2([H])CO1
Structure Classification
- Phenylpropanoids
- Lignans
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. David E.Jackson, et al. Aryltetralin lignans from Podophyllum hexandrum and Podophyllum peltatum. Phytochemistry. 1984, 23 (5): 1147-1152.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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