Search Result

Results for "

kb-cell

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (1) Antibiotic (1) Apoptosis (4) Arenavirus (2) Bacterial (3) DNA Alkylator/Crosslinker (1) Drug Derivative (1) Drug Intermediate (1) Environmental Pollutants (1) Estrogen Receptor/ERR (1) Folate Receptor (FR) (1) Fungal (2) HSP (1) Microtubule/Tubulin (2) P-glycoprotein (1) Parasite (1) Reference Standards (1)
By Research Areas:	Cancer (12) Infection (7) Inflammation/Immunology (1)

Inhibitors & Agonists

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0128

Sclareol 3 Publications Verification	Environmental Pollutants Apoptosis	Cancer
Sclareol is isolated from Salvia sclarea with anticarcinogenic activity. Sclareol shows strong cytotoxic activity against mouse leukemia (P-388), human epidermal carcinoma (KB) cells and human leukemia cell lines. Sclareol induces cell apoptosis .

HY-N2815

Ursolic acid acetate Acetylursolic acid; 3-Acetylursolic acid	Parasite HSP	Infection Cancer
Ursolic acid acetate (Acetylursolic acid) is a triterpenoid compound and an inhibitor of Plasmodium falciparum heat shock protein 90 (PfHsp90) with a K_D of 8.16 μM. Ursolic acid acetate is cytotoxic to KB cells, with an IC₅₀ value of 8.4 μM. Ursolic acid acetate can be used in tumor and antimalarial research .

HY-N4121

Isocurcumenol 1 Publications Verification	Estrogen Receptor/ERR Apoptosis	Cancer
Isocurcumenol, an estrogen receptor alpha (ERα) inhibitor isolated from Curcuma zedoaria Rhizomes, possesses anti-tumor acticity, with IC₅₀ values of 99.1μg/mL and 178.2 μg/mL in DLA and KB cells, respectively .

HY-130082

DM4-SMe	ADC Payload Microtubule/Tubulin	Cancer
DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC₅₀ of 0.026 nM. DM4-SMe is a highly toxic metabolite that can be oxidized and detoxified by human liver microsomes .

HY-P0323A

GP(33-41) TFA 1 Publications Verification LCMV GP(33-41) C-peptide TFA	Arenavirus	Infection
GP(33-41) TFA, a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus. GP(33-41) TFA can upregulate H-2D ^b molecules at the RMA-S (Db Kb) cell surface with a SC₅₀ of 344 nM .

HY-N15199

Schisanlactone A	Others	Cancer
Schisanlactone A is a natural triterpenoid compound. Schisanlactone A has moderate cytotoxicity, with its IC₅₀ value being 63.3 μM against KB cells. Schisanlactone A does not possess antibacterial or tyrosinase inhibitory activities. Schisanlactone A can be used for the study of oral epidermoid carcinoma .

HY-N1251

Scholaricine	Others	Others
Scholaricine (compound 13 ) is an alkaloid isolated from the leaf and stem-bark extracts of Alstonia spatulata. Scholaricine reverse multidrug resistance in vincristine-resistant KB cells with an IC₅₀ value of 13.35 μM .

HY-P0323

GP(33-41) LCMV GP(33-41) C-peptide	Arenavirus	Infection
GP(33-41), a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus, and can upregulate H-2D ^b molecules at the RMA-S (Db Kb) cell surface with a SC₅₀ of 344 nM .

HY-16181

EC-0225	Folate Receptor (FR) Microtubule/Tubulin DNA Alkylator/Crosslinker	Cancer
EC-0225, a folate conjugate of two agents- one a potent microtubule inhibiting agent, and the second a DNA alkylating agent. EC-0225 inhibits the growth of folate receptor (FR)-positive KB cells with an IC₅₀ of ~1 nM. EC-0225 can be selectively delivered to advanced FR-positive tumors without causing overt toxicity, such as lung carcinoma .

HY-117708

Antitumor agent-144	Drug Intermediate	Cancer
Antitumor agent-144 (16) is an antitumor agent, with IC₅₀ values of 2.6 μM and 8.4 μM in L1210 and KB cells, respectively .

HY-N3916

Galanolactone (+)-Galanolactone	Fungal	Infection
Galanolactone is a natural product that can be isolated from the seeds of Alpinia galanga. Galanolactone shows antifungal activitie. Galanolactone shows cytotoxicity against KB cells with an EC₅₀ of 38.5 µg/ml .

HY-113796

Kopsoffinol	Others	Cancer
Kopsoffinol, a bisindole alkaloid, shows in vitro growth inhibitory activity against human PC-3, HCT-116, MCF-7, and A549 cells and moderate effects in reversing multidrug-resistance in vincristine-resistant human KB cells .

HY-129306

Gilvocarcin M	Antibiotic Bacterial	Inflammation/Immunology
Gilvocarcin M is an antibiotic and can be isolated from S. gilvotanareus. Gilvocarcin M is active against S. aureus at a concentration of 32 µg/ml and inhibits growth of KB cells with the IC₅₀ of 0.52 µg/ml. Gilvocarcin M intercalates into bacteriophage PM2 DNA .

HY-N0128R

Sclareol (Standard)	Reference Standards Apoptosis	Cancer
Sclareol (Standard) is the analytical standard of Sclareol. This product is intended for research and analytical applications. Sclareol is isolated from Salvia sclarea with anticarcinogenic activity. Sclareol shows strong cytotoxic activity against mouse leukemia (P-388), human epidermal carcinoma (KB) cells and human leukemia cell lines. Sclareol induces cell apoptosis .

HY-N14853

Ossamycin	Bacterial Fungal	Infection
Ossamycin is a macrolide antibiotic. Ossamycin has anti-fungal effect, and it has weaker anti-Gram-positive bacterial effect. Ossamycin inhibits L cells, Epstein-Barr ascites cancer cells, KB cells, sarcoma-180 cells, L-1210 cells, HeLa cells in cell culture with IC₅₀s (μg/mL) of 0.007, 0.008, 0.005, 0.008, 0.003, 0.005, respectively .

HY-122324

Tylophorine (+)-(S)-Tylophorine; DCB-3500; NSC-717335	Others	Cancer
Tylophorine and its analogs are benzoindole alkaloids, most of which are derived from Garcinia plants. Tylophorine analogs all show potent growth inhibition against human hepatocellular carcinoma HepG2 and human nasopharyngeal carcinoma KB cell lines. Tylophorine analogs can also induce increased albumin expression and inhibit α-fetoprotein expression in HepG2 cells, and have the potential to induce HepG2 cell differentiation .

HY-125322

Reveromycin C	Bacterial	Infection
Reveromycin C is a polyketide originally isolated from Streptomyces that has antifungal activity against C. albicans (MICs=2.0 and >500 μg/mL at pH 3 and 7.4, respectively). Reveromycin C inhibits EGF-induced mitogenic activity in the Balb/MK mouse epidermal cell line. It also reverses the morphology of sarcoma-virus-transformed NRK rat kidney cells (EC₅₀=1.58 μg/mL) and inhibits proliferation of KB cells and K562 human chronic myelogenous leukemia cells (IC₅₀=2.0 μg/mL for both).

HY-175522

P-gp-IN-31	P-glycoprotein Apoptosis	Cancer
P-gp-IN-31 is a P-glycoprotein (P-gp) inhibitor with IC₅₀ values of 0.42 μM for KB cells and 0.43 μM for MDR KBvin cells. P-gp-IN-31 can pass P-gp-mediated drug efflux mechanisms and shows collateral sensitivity via P-gp downregulation. P-gp-IN-31 inhibits cell proliferation, induces apoptosis and arrests the cell cycle at G2/M phase. P-gp-IN-31 can be used for the research of cancer, such as multidrug-resistant (MDR) malignancies .

HY-W779743

NE58043	Drug Derivative	Infection Cancer
NE58043 (Compound 21) is a nitrogen-containing bisphosphonate compound. NE58043 has no significant inhibitory activity against Entamoeba histolytica and Plasmodium falciparum with IC₅₀ > 200 μM. NE58043 shows a LD₅₀ of 171 μM for human nasopharyngeal carcinoma KB cells. NE58043 can be used for the research of cancer and infection, such as nasopharyngeal carcinoma .

Cat. No.	Product Name	Target	Research Area

HY-P0323A

GP(33-41) TFA 1 Publications Verification LCMV GP(33-41) C-peptide TFA	Arenavirus	Infection
GP(33-41) TFA, a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus. GP(33-41) TFA can upregulate H-2D ^b molecules at the RMA-S (Db Kb) cell surface with a SC₅₀ of 344 nM .

HY-P0323

GP(33-41) LCMV GP(33-41) C-peptide	Arenavirus	Infection
GP(33-41), a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus, and can upregulate H-2D ^b molecules at the RMA-S (Db Kb) cell surface with a SC₅₀ of 344 nM .

Sclareol 3 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Labiatae Ulex europaeus L. Diterpenoids Plants Disease Research Fields Oxytropis falcata Bunge Source Classification Cancer	Environmental Pollutants Apoptosis
Sclareol is isolated from Salvia sclarea with anticarcinogenic activity. Sclareol shows strong cytotoxic activity against mouse leukemia (P-388), human epidermal carcinoma (KB) cells and human leukemia cell lines. Sclareol induces cell apoptosis .

Ursolic acid acetate Acetylursolic acid; 3-Acetylursolic acid	Triterpenes other families Classification of Application Fields Terpenoids Plants Disease Research Fields Source Classification Cancer	Parasite HSP
Ursolic acid acetate (Acetylursolic acid) is a triterpenoid compound and an inhibitor of Plasmodium falciparum heat shock protein 90 (PfHsp90) with a K_D of 8.16 μM. Ursolic acid acetate is cytotoxic to KB cells, with an IC₅₀ value of 8.4 μM. Ursolic acid acetate can be used in tumor and antimalarial research .

Isocurcumenol 1 Publications Verification	other families Classification of Application Fields Terpenoids Sesquiterpenes Plants Disease Research Fields Source Classification Cancer	Estrogen Receptor/ERR Apoptosis
Isocurcumenol, an estrogen receptor alpha (ERα) inhibitor isolated from Curcuma zedoaria Rhizomes, possesses anti-tumor acticity, with IC₅₀ values of 99.1μg/mL and 178.2 μg/mL in DLA and KB cells, respectively .

Schisanlactone A	Triterpenes Structural Classification Terpenoids Cardiacglycosides Schisandra henryi subsp. yunnanensis (A. C. Smith) R. M. K. Saunders Plants Schisandraceae Steroids Source Classification	Others
Schisanlactone A is a natural triterpenoid compound. Schisanlactone A has moderate cytotoxicity, with its IC₅₀ value being 63.3 μM against KB cells. Schisanlactone A does not possess antibacterial or tyrosinase inhibitory activities. Schisanlactone A can be used for the study of oral epidermoid carcinoma .

Scholaricine	Apocynaceae Alkaloids Alstonia spatulata Blume Other Alkaloids Plants Source Classification	Others
Scholaricine (compound 13 ) is an alkaloid isolated from the leaf and stem-bark extracts of Alstonia spatulata. Scholaricine reverse multidrug resistance in vincristine-resistant KB cells with an IC₅₀ value of 13.35 μM .

Kopsoffinol	Apocynaceae Alkaloids Other Alkaloids Kopsia pauciflora Hook.f. Plants Source Classification	Others
Kopsoffinol, a bisindole alkaloid, shows in vitro growth inhibitory activity against human PC-3, HCT-116, MCF-7, and A549 cells and moderate effects in reversing multidrug-resistance in vincristine-resistant human KB cells .

Gilvocarcin M	Microorganisms Coumarins Phenylpropanoids Source Classification	Antibiotic Bacterial
Gilvocarcin M is an antibiotic and can be isolated from S. gilvotanareus. Gilvocarcin M is active against S. aureus at a concentration of 32 µg/ml and inhibits growth of KB cells with the IC₅₀ of 0.52 µg/ml. Gilvocarcin M intercalates into bacteriophage PM2 DNA .

Sclareol (Standard)	Structural Classification Terpenoids Labiatae Ulex europaeus L. Diterpenoids Plants Oxytropis falcata Bunge Source Classification	Reference Standards Apoptosis
Sclareol (Standard) is the analytical standard of Sclareol. This product is intended for research and analytical applications. Sclareol is isolated from Salvia sclarea with anticarcinogenic activity. Sclareol shows strong cytotoxic activity against mouse leukemia (P-388), human epidermal carcinoma (KB) cells and human leukemia cell lines. Sclareol induces cell apoptosis .

Ossamycin	Microorganisms Macrolide Antibiotics Antibiotics Source Classification	Bacterial Fungal
Ossamycin is a macrolide antibiotic. Ossamycin has anti-fungal effect, and it has weaker anti-Gram-positive bacterial effect. Ossamycin inhibits L cells, Epstein-Barr ascites cancer cells, KB cells, sarcoma-180 cells, L-1210 cells, HeLa cells in cell culture with IC₅₀s (μg/mL) of 0.007, 0.008, 0.005, 0.008, 0.003, 0.005, respectively .

Tylophorine (+)-(S)-Tylophorine; DCB-3500; NSC-717335	Apocynaceae Plants Tylophora Source Classification	Others
Tylophorine and its analogs are benzoindole alkaloids, most of which are derived from Garcinia plants. Tylophorine analogs all show potent growth inhibition against human hepatocellular carcinoma HepG2 and human nasopharyngeal carcinoma KB cell lines. Tylophorine analogs can also induce increased albumin expression and inhibit α-fetoprotein expression in HepG2 cells, and have the potential to induce HepG2 cell differentiation .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Name
Email *

	Sorry, but the email address you supplied was invalid.

kb-cell

Inhibitors & Agonists

Peptides

NaturalProducts

Natural
Products