Tylophorine
Tylophorine and its analogs are benzoindole alkaloids, most of which are derived from Garcinia plants. Tylophorine analogs all show potent growth inhibition against human hepatocellular carcinoma HepG2 and human nasopharyngeal carcinoma KB cell lines. Tylophorine analogs can also induce increased albumin expression and inhibit α-fetoprotein expression in HepG2 cells, and have the potential to induce HepG2 cell differentiation.
For research use only. We do not sell to patients.
- CAS No.: 482-20-2
- Formula: C24H27NO4
- Molecular Weight:393.48
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
0.7 μM
Compound: 2
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Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
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[PMID: 22417638] |
| CCRF-CEM | GI50 |
15 nM
Compound: DCB-3500, NSC-717335 (+)-S-tylophorine
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Growth inhibition of human CEM cells
Growth inhibition of human CEM cells
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[PMID: 18077159] |
| HL-60 | GI50 |
0.01 μM
Compound: 2
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Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay
Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay
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[PMID: 22417638] |
| MCF7 | GI50 |
0.042 μM
Compound: (S)-tylophorine
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Growth inhibition in human MCF7 cells after 72 hrs by alamar blue assay
Growth inhibition in human MCF7 cells after 72 hrs by alamar blue assay
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[PMID: 22910225] |
| PANC-1 | GI50 |
12 nM
Compound: DCB-3500, NSC-717335 (+)-S-tylophorine
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Growth inhibition of human PANC1 cells
Growth inhibition of human PANC1 cells
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[PMID: 18077159] |
| RAW264.7 | IC50 |
274 nM
Compound: 2
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Cytotoxicity against mouse RAW264.7 cells after 48 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells after 48 hrs by MTT assay
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[PMID: 25221661] |
| RAW264.7 | IC50 |
78 nM
Compound: 2
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Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production after 6 hrs by ELISA
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production after 6 hrs by ELISA
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[PMID: 25221661] |
| Splenocyte | IC50 |
1134 nM
Compound: 2
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Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 24 hrs by ELISA
Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 24 hrs by ELISA
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[PMID: 25221661] |
| Splenocyte | IC50 |
55 nM
Compound: 2
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Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 4 hrs by ELISA
Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 4 hrs by ELISA
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[PMID: 25221661] |
Chemical Information
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CAS No. 482-20-2
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Appearance Solid
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Molecular Weight 393.48
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Formula C24H27NO4
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SMILES
COC1=C(C=C2C3=CC(OC)=C(C=C3C4=C(C2=C1)CN5[C@]([H])(C4)CCC5)OC)OC
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Synonyms
(+)-(S)-Tylophorine; DCB-3500; NSC-717335
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 44.46 mg/mL (112.99 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5414 mL | 12.7071 mL | 25.4143 mL | 63.5356 mL |
| 5 mM | 0.5083 mL | 2.5414 mL | 5.0829 mL | 12.7071 mL | |
| 10 mM | 0.2541 mL | 1.2707 mL | 2.5414 mL | 6.3536 mL | |
| 15 mM | 0.1694 mL | 0.8471 mL | 1.6943 mL | 4.2357 mL | |
| 20 mM | 0.1271 mL | 0.6354 mL | 1.2707 mL | 3.1768 mL | |
| 25 mM | 0.1017 mL | 0.5083 mL | 1.0166 mL | 2.5414 mL | |
| 30 mM | 0.0847 mL | 0.4236 mL | 0.8471 mL | 2.1179 mL | |
| 40 mM | 0.0635 mL | 0.3177 mL | 0.6354 mL | 1.5884 mL | |
| 50 mM | 0.0508 mL | 0.2541 mL | 0.5083 mL | 1.2707 mL | |
| 60 mM | 0.0424 mL | 0.2118 mL | 0.4236 mL | 1.0589 mL | |
| 80 mM | 0.0318 mL | 0.1588 mL | 0.3177 mL | 0.7942 mL | |
| 100 mM | 0.0254 mL | 0.1271 mL | 0.2541 mL | 0.6354 mL |
Tylophorine Related Classifications
HY-122324 Related Classifications
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