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Cat. No.: HY-122324A

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(-)-Tylophorine

Name: (-)-Tylophorine
Brand: MedChemExpress
SKU: HY-122324A
Availability: PreOrder

(Synonyms: (-)-(R)-Tylophorine; (-)-DCB-3500; (-)-NSC-717335)

(-)-Tylophorine ((-)-(R)-Tylophorine) is a potent cytotoxic agent with activity against both drug-sensitive and multidrug-resistant cancer cell lines. (-)-Tylophorine has been explored in biomedical research for its anticancer applications.

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CAS No.: 111408-21-0
Formule: C₂₄H₂₇NO₄
Masse moléculaire:393.48

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

(-)-Tylophorine Chemical Structure

CAS No.: 111408-21-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Protocole (1)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	0.5 μM Compound: 3	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 22417638]
CCRF-CEM	GI₅₀	67 nM Compound: (-)-R-tylophorine	Growth inhibition of human CEM cells Growth inhibition of human CEM cells	[PMID: 18077159]
HeLa	IC₅₀	3.1 μM Compound: 5	Cytotoxicity against human HeLa cells after 48 hrs by WST8 colorimetric assay Cytotoxicity against human HeLa cells after 48 hrs by WST8 colorimetric assay	[PMID: 19938815]
HL-60	GI₅₀	0.1 μM Compound: 3	Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay	[PMID: 22417638]
HONE1 cell line	GI₅₀	0.27 μM Compound: 9a	Growth inhibition of human HONE1 cells Growth inhibition of human HONE1 cells	[PMID: 23167614]
Huh-7	CC₅₀	>7.91 μM Compound: GNF-Pf-838	NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)	[PMID: 18579783]
KB 3-1	IC₅₀	214 nM Compound: 5	Cytotoxicity against drug-resistant human KB-3-1 cells by MTS/PMS assay Cytotoxicity against drug-resistant human KB-3-1 cells by MTS/PMS assay	[PMID: 12350151]
KB-V1	IC₅₀	173 nM Compound: 5	Cytotoxicity against multidrug-resistant human KBV1 cells by MTS/PMS assay Cytotoxicity against multidrug-resistant human KBV1 cells by MTS/PMS assay	[PMID: 12350151]
MCF7	GI₅₀	0.032 μM Compound: (R)-tylophorine	Growth inhibition in human MCF7 cells after 72 hrs by alamar blue assay Growth inhibition in human MCF7 cells after 72 hrs by alamar blue assay	[PMID: 22910225]
MCF7	GI₅₀	0.24 μM Compound: 9a	Growth inhibition of human MCF7 cells Growth inhibition of human MCF7 cells	[PMID: 23167614]
NCI-H460	GI₅₀	0.23 μM Compound: 9a	Growth inhibition of human NCI-H460 cells Growth inhibition of human NCI-H460 cells	[PMID: 23167614]
NUGC-3	GI₅₀	0.19 μM Compound: 9a	Growth inhibition of human NUGC3 cells Growth inhibition of human NUGC3 cells	[PMID: 23167614]
PANC-1	GI₅₀	29 nM Compound: (-)-R-tylophorine	Growth inhibition of human PANC1 cells Growth inhibition of human PANC1 cells	[PMID: 18077159]
RAW264.7	CC₅₀	1.24 μM Compound: 9a	Cytotoxicity against mouse RAW264.7 cells Cytotoxicity against mouse RAW264.7 cells	[PMID: 23167614]
RAW264.7	EC₅₀	0.27 μM Compound: 9a	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 18 hrs by nitrate/nitrite assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 18 hrs by nitrate/nitrite assay	[PMID: 23167614]
RAW264.7	IC₅₀	430 nM Compound: 3	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production after 6 hrs by ELISA Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production after 6 hrs by ELISA	[PMID: 25221661]
RAW264.7	IC₅₀	823 nM Compound: 3	Cytotoxicity against mouse RAW264.7 cells after 48 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells after 48 hrs by MTT assay	[PMID: 25221661]
SF-268	GI₅₀	0.27 μM Compound: 9a	Growth inhibition of human SF268 cells Growth inhibition of human SF268 cells	[PMID: 23167614]
Splenocyte	IC₅₀	1215 nM Compound: 3	Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 24 hrs by ELISA Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 24 hrs by ELISA	[PMID: 25221661]
Splenocyte	IC₅₀	208 nM Compound: 3	Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 4 hrs by ELISA Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 4 hrs by ELISA	[PMID: 25221661]

Chemical Information

CAS No. 111408-21-0
Masse moléculaire 393.48
Formule C₂₄H₂₇NO₄
SMILES

COC1=C(OC)C=C2C3=CC(OC)=C(OC)C=C3C4=C(CN5[C@@](CCC5)([H])C4)C2=C1
Synonyms

(-)-(R)-Tylophorine; (-)-DCB-3500; (-)-NSC-717335
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Cell Biology

Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Total syntheses of the tylophora alkaloids cryptopleurine, (-)-antofine, (-)-tylophorine, and (-)-ficuseptine C

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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