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  5. Tylophora
  6. (-)-Tylophorine

(-)-Tylophorine  (Synonyms: (-)-(R)-Tylophorine; (-)-DCB-3500; (-)-NSC-717335)

Cat. No.: HY-122324A
Handling Instructions Technical Support

(-)-Tylophorine ((-)-(R)-Tylophorine) is a potent cytotoxic agent with activity against both drug-sensitive and multidrug-resistant cancer cell lines. (-)-Tylophorine has been explored in biomedical research for its anticancer applications.

For research use only. We do not sell to patients.

(-)-Tylophorine

(-)-Tylophorine Chemical Structure

CAS No. : 111408-21-0

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Other Forms of (-)-Tylophorine:

(-)-Tylophorine Related Antibodies

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Description

(-)-Tylophorine ((-)-(R)-Tylophorine) is a potent cytotoxic agent with activity against both drug-sensitive and multidrug-resistant cancer cell lines. (-)-Tylophorine has been explored in biomedical research for its anticancer applications[1].

Cellular Effect
Cell Line Type Value Description References
A549 GI50
0.5 μM
Compound: 3
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
[PMID: 22417638]
CCRF-CEM GI50
67 nM
Compound: (-)-R-tylophorine
Growth inhibition of human CEM cells
Growth inhibition of human CEM cells
[PMID: 18077159]
HL-60 GI50
0.1 μM
Compound: 3
Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay
Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay
[PMID: 22417638]
HeLa IC50
3.1 μM
Compound: 5
Cytotoxicity against human HeLa cells after 48 hrs by WST8 colorimetric assay
Cytotoxicity against human HeLa cells after 48 hrs by WST8 colorimetric assay
[PMID: 19938815]
Huh-7 CC50
> 7.91 μM
Compound: GNF-Pf-838
NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
[PMID: 18579783]
KB 3-1 IC50
214 nM
Compound: 5
Cytotoxicity against drug-resistant human KB-3-1 cells by MTS/PMS assay
Cytotoxicity against drug-resistant human KB-3-1 cells by MTS/PMS assay
[PMID: 12350151]
KB-V1 IC50
173 nM
Compound: 5
Cytotoxicity against multidrug-resistant human KBV1 cells by MTS/PMS assay
Cytotoxicity against multidrug-resistant human KBV1 cells by MTS/PMS assay
[PMID: 12350151]
MCF7 GI50
0.032 μM
Compound: (R)-tylophorine
Growth inhibition in human MCF7 cells after 72 hrs by alamar blue assay
Growth inhibition in human MCF7 cells after 72 hrs by alamar blue assay
[PMID: 22910225]
MCF7 GI50
0.24 μM
Compound: 9a
Growth inhibition of human MCF7 cells
Growth inhibition of human MCF7 cells
[PMID: 23167614]
NCI-H460 GI50
0.23 μM
Compound: 9a
Growth inhibition of human NCI-H460 cells
Growth inhibition of human NCI-H460 cells
[PMID: 23167614]
NUGC-3 GI50
0.19 μM
Compound: 9a
Growth inhibition of human NUGC3 cells
Growth inhibition of human NUGC3 cells
[PMID: 23167614]
PANC-1 GI50
29 nM
Compound: (-)-R-tylophorine
Growth inhibition of human PANC1 cells
Growth inhibition of human PANC1 cells
[PMID: 18077159]
RAW264.7 CC50
1.24 μM
Compound: 9a
Cytotoxicity against mouse RAW264.7 cells
Cytotoxicity against mouse RAW264.7 cells
[PMID: 23167614]
RAW264.7 EC50
0.27 μM
Compound: 9a
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 18 hrs by nitrate/nitrite assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 18 hrs by nitrate/nitrite assay
[PMID: 23167614]
RAW264.7 IC50
430 nM
Compound: 3
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production after 6 hrs by ELISA
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production after 6 hrs by ELISA
[PMID: 25221661]
RAW264.7 IC50
823 nM
Compound: 3
Cytotoxicity against mouse RAW264.7 cells after 48 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells after 48 hrs by MTT assay
[PMID: 25221661]
SF-268 GI50
0.27 μM
Compound: 9a
Growth inhibition of human SF268 cells
Growth inhibition of human SF268 cells
[PMID: 23167614]
Splenocyte IC50
1215 nM
Compound: 3
Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 24 hrs by ELISA
Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 24 hrs by ELISA
[PMID: 25221661]
Splenocyte IC50
208 nM
Compound: 3
Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 4 hrs by ELISA
Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 4 hrs by ELISA
[PMID: 25221661]
Molecular Weight

393.48

Formula

C24H27NO4
CAS No.
SMILES

COC1=C(OC)C=C2C3=CC(OC)=C(OC)C=C3C4=C(CN5[C@@](CCC5)([H])C4)C2=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(-)-Tylophorine Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Tylophorine111408-21-0(-)-(R)-Tylophorine (-)-DCB-3500 (-)-NSC-717335OthersInhibitorinhibitorinhibit

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