(-)-Tylophorine
(-)-Tylophorine ((-)-(R)-Tylophorine) is a potent cytotoxic agent with activity against both drug-sensitive and multidrug-resistant cancer cell lines. (-)-Tylophorine has been explored in biomedical research for its anticancer applications.
For research use only. We do not sell to patients.
- CAS No.: 111408-21-0
- Formula: C24H27NO4
- Molecular Weight:393.48
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
0.5 μM
Compound: 3
|
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
|
[PMID: 22417638] |
| CCRF-CEM | GI50 |
67 nM
Compound: (-)-R-tylophorine
|
Growth inhibition of human CEM cells
Growth inhibition of human CEM cells
|
[PMID: 18077159] |
| HeLa | IC50 |
3.1 μM
Compound: 5
|
Cytotoxicity against human HeLa cells after 48 hrs by WST8 colorimetric assay
Cytotoxicity against human HeLa cells after 48 hrs by WST8 colorimetric assay
|
[PMID: 19938815] |
| HL-60 | GI50 |
0.1 μM
Compound: 3
|
Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay
Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay
|
[PMID: 22417638] |
| HONE1 cell line | GI50 |
0.27 μM
Compound: 9a
|
Growth inhibition of human HONE1 cells
Growth inhibition of human HONE1 cells
|
[PMID: 23167614] |
| Huh-7 | CC50 |
>7.91 μM
Compound: GNF-Pf-838
|
NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
|
[PMID: 18579783] |
| KB 3-1 | IC50 |
214 nM
Compound: 5
|
Cytotoxicity against drug-resistant human KB-3-1 cells by MTS/PMS assay
Cytotoxicity against drug-resistant human KB-3-1 cells by MTS/PMS assay
|
[PMID: 12350151] |
| KB-V1 | IC50 |
173 nM
Compound: 5
|
Cytotoxicity against multidrug-resistant human KBV1 cells by MTS/PMS assay
Cytotoxicity against multidrug-resistant human KBV1 cells by MTS/PMS assay
|
[PMID: 12350151] |
| MCF7 | GI50 |
0.032 μM
Compound: (R)-tylophorine
|
Growth inhibition in human MCF7 cells after 72 hrs by alamar blue assay
Growth inhibition in human MCF7 cells after 72 hrs by alamar blue assay
|
[PMID: 22910225] |
| MCF7 | GI50 |
0.24 μM
Compound: 9a
|
Growth inhibition of human MCF7 cells
Growth inhibition of human MCF7 cells
|
[PMID: 23167614] |
| NCI-H460 | GI50 |
0.23 μM
Compound: 9a
|
Growth inhibition of human NCI-H460 cells
Growth inhibition of human NCI-H460 cells
|
[PMID: 23167614] |
| NUGC-3 | GI50 |
0.19 μM
Compound: 9a
|
Growth inhibition of human NUGC3 cells
Growth inhibition of human NUGC3 cells
|
[PMID: 23167614] |
| PANC-1 | GI50 |
29 nM
Compound: (-)-R-tylophorine
|
Growth inhibition of human PANC1 cells
Growth inhibition of human PANC1 cells
|
[PMID: 18077159] |
| RAW264.7 | CC50 |
1.24 μM
Compound: 9a
|
Cytotoxicity against mouse RAW264.7 cells
Cytotoxicity against mouse RAW264.7 cells
|
[PMID: 23167614] |
| RAW264.7 | EC50 |
0.27 μM
Compound: 9a
|
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 18 hrs by nitrate/nitrite assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 18 hrs by nitrate/nitrite assay
|
[PMID: 23167614] |
| RAW264.7 | IC50 |
430 nM
Compound: 3
|
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production after 6 hrs by ELISA
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production after 6 hrs by ELISA
|
[PMID: 25221661] |
| RAW264.7 | IC50 |
823 nM
Compound: 3
|
Cytotoxicity against mouse RAW264.7 cells after 48 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells after 48 hrs by MTT assay
|
[PMID: 25221661] |
| SF-268 | GI50 |
0.27 μM
Compound: 9a
|
Growth inhibition of human SF268 cells
Growth inhibition of human SF268 cells
|
[PMID: 23167614] |
| Splenocyte | IC50 |
1215 nM
Compound: 3
|
Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 24 hrs by ELISA
Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 24 hrs by ELISA
|
[PMID: 25221661] |
| Splenocyte | IC50 |
208 nM
Compound: 3
|
Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 4 hrs by ELISA
Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 4 hrs by ELISA
|
[PMID: 25221661] |
Chemical Information
-
CAS No. 111408-21-0
-
Molecular Weight 393.48
-
Formula C24H27NO4
-
SMILES
COC1=C(OC)C=C2C3=CC(OC)=C(OC)C=C3C4=C(CN5[C@@](CCC5)([H])C4)C2=C1
-
Synonyms
(-)-(R)-Tylophorine; (-)-DCB-3500; (-)-NSC-717335
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)