482-20-2
Chemical Structure
Tylophorine
Synonym(s): (+)-(S)-Tylophorine; DCB-3500; NSC-717335
- CAS No.: 482-20-2
- Formula:C24H27NO4
- Molecular Weight:393.48
IUPAC Name: (S)-2,3,6,7-tetramethoxy-9,11,12,13,13a,14-hexahydrodibenzo[f,h]pyrrolo[1,2-b]isoquinoline
InChIKey: SSEUDFYBEOIWGF-AWEZNQCLSA-N
SMILES: COC1=C(C=C2C3=CC(OC)=C(C=C3C4=C(C2=C1)CN5[C@]([H])(C4)CCC5)OC)OC
Biological Activity: Tylophorine and its analogs are benzoindole alkaloids, most of which are derived from Garcinia plants. Tylophorine analogs all show potent growth inhibition against human hepatocellular carcinoma HepG2 and human nasopharyngeal carcinoma KB cell lines. Tylophorine analogs can also induce increased albumin expression and inhibit α-fetoprotein expression in HepG2 cells, and have the potential to induce HepG2 cell differentiation[1].
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Tylophorine | Tylophorine and its analogs are benzoindole alkaloids, most of which are derived from Garcinia plants. Tylophorine analogs all show potent growth inhibition against human hepatocellular carcinoma HepG2 and human nasopharyngeal carcinoma KB cell lines. Tylophorine analogs can also induce increased albumin expression and inhibit α-fetoprotein expression in HepG2 cells, and have the potential to induce HepG2 cell differentiation. | |||||||||||||||||||||
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Keywords
