5'-O-DMTr-3'-O-methyl uridine-3'-CED-phosphoramidite

Cat. No.: HY-134337 Pureza: 98.01%: Ficha de datos
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5'-O-DMTr-3'-O-methyl uridine-3'-CED-phosphoramidite is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents.

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5'-O-DMTr-3'-O-methyl uridine-3'-CED-phosphoramidite Estructura química

No. CAS : 179479-05-1

Tamaño	Stock	Cantidad
Muestra gratis (0.1 - 0.2 mg)	Solicite ahora
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
250 mg	En stock	Estimated Time of Arrival: December 31
500 mg	Obtener un presupuesto
1 g	Obtener un presupuesto

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Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

Peso molecular

760.81

Fòrmula

C₄₀H₄₉N₄O₉P

No. CAS

179479-05-1

Appearance

Solid

Color

White to off-white

SMILES

O=C(C=C1)NC(N1[C@@H]2O[C@H](COC(C3=CC=CC=C3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)[C@@H](OC)[C@H]2OP(OCCC#N)N(C(C)C)C(C)C)=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 200 mg/mL (262.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3144 mL	6.5719 mL	13.1439 mL
5 mM	0.2629 mL	1.3144 mL	2.6288 mL
10 mM	0.1314 mL	0.6572 mL	1.3144 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (6.57 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Pureza y Documentación

Purity: 98.01%

Select Batch:

Ficha de datos (279 KB) SDS (252 KB)

COA (262 KB) HNMR (328 KB) RP-HPLC (263 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Connolly GP, et al. Uridine and its nucleotides: biological actions, therapeutic potentials. Trends Pharmacol Sci. 1999 May;20(5):218-25. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3144 mL	6.5719 mL	13.1439 mL	32.8597 mL
	5 mM	0.2629 mL	1.3144 mL	2.6288 mL	6.5719 mL
	10 mM	0.1314 mL	0.6572 mL	1.3144 mL	3.2860 mL
	15 mM	0.0876 mL	0.4381 mL	0.8763 mL	2.1906 mL
	20 mM	0.0657 mL	0.3286 mL	0.6572 mL	1.6430 mL
	25 mM	0.0526 mL	0.2629 mL	0.5258 mL	1.3144 mL
	30 mM	0.0438 mL	0.2191 mL	0.4381 mL	1.0953 mL
	40 mM	0.0329 mL	0.1643 mL	0.3286 mL	0.8215 mL
	50 mM	0.0263 mL	0.1314 mL	0.2629 mL	0.6572 mL
	60 mM	0.0219 mL	0.1095 mL	0.2191 mL	0.5477 mL
	80 mM	0.0164 mL	0.0821 mL	0.1643 mL	0.4107 mL
	100 mM	0.0131 mL	0.0657 mL	0.1314 mL	0.3286 mL