5-PA-dUTP  (Synonyms: 5-Propargylamino-dUTP)

5-PA-dUTP (5-Propargylamino-dUTP) is a C5-modified nucleotide and can be incorporated into DNA nanoparticles (DNPs) for photosensitizer delivery^[1]. 5-PA-dUTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

521.20

C₁₂H₁₈N₃O₁₄P₃

179101-49-6

Liquid

Colorless to light yellow

O=C1N([C@H]2C[C@H](O)[C@@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)O2)C=C(C(N1)=O)C#CCN

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Kyoung-Ran Kim, et al.Shaping Rolling Circle Amplification Products into DNA Nanoparticles by Incorporation of Modified Nucleotides and Their Application to In Vitro and In Vivo Delivery of a Photosensitizer. Molecules. 2018 Jul 23;23(7):1833.  [Content Brief]