1. JAK/STAT Signaling
  2. Pim
  3. AZD1208


製品番号: HY-15604 純度: 99.76%

AZD1208 is a novel, orally bioavailable, highly selective PIM kinases inhibitor.


AZD1208 構造式

AZD1208 構造式

CAS 番号 : 1204144-28-4

容量 価格(税別) 在庫状況 数量
無料サンプル (0.5-1 mg)   今すぐ申し込む  
10 mM * 1 mL in DMSO USD 79 在庫あり
Estimated Time of Arrival: December 31
5 mg USD 72 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 102 在庫あり
Estimated Time of Arrival: December 31
50 mg USD 300 在庫あり
Estimated Time of Arrival: December 31
100 mg USD 540 在庫あり
Estimated Time of Arrival: December 31
200 mg USD 756 在庫あり
Estimated Time of Arrival: December 31
500 mg   お問い合わせ  
1 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください


Based on 9 publication(s) in Google Scholar

Other Forms of AZD1208:

Top Publications Citing Use of Products

    AZD1208 purchased from MCE. Usage Cited in: ENeuro. 2019 Aug 22;6(4). pii: ENEURO.0003-19.2019.

    PIM and PRK kinases function similarly in vitro. PRK-1 autophosphorylation was analysed in the absence (-) or presence (+) of 10 μM DHPCC-9, AZD-1208 and SGI-1776. The phosphorylated protein was visualized by immunoblotting with the phospho-RXXS*/T* antibody, which has several potential target sites in PRK-1.
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    AZD1208 is a novel, orally bioavailable, highly selective PIM kinases inhibitor.


    AZD1208 shows good antiproliferative activity in a megakaryoblastic leukemia cell line, MOLM-16, with GI50 values less than 100 nM[1]. AZD1208 (10 μM) inhibits the growth of Ramos cells, and at 1 μM, strongly inhibits PIM kinases in all cell at 1 μM. AZD1208 induces apoptosis, and PIM2 knockdown is mainly associated with an alteration of the cell cycle[2]. The combination of AZD1208 and AZD2014 rapidly activates AMPKα, a negative regulator of translation machinery through mTORC1/2 signaling in AML cells; profoundly inhibits AKT and 4EBP1 activation; and suppresses polysome formation[3].





    CAS 番号



    O=C(NC/1=O)SC1=C/C2=C(N3C[[email protected]](N)CCC3)C(C4=CC=CC=C4)=CC=C2


    Room temperature in continental US; may vary elsewhere.

    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度

    DMSO : 50 mg/mL (131.76 mM; Need ultrasonic)

    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.6352 mL 13.1759 mL 26.3519 mL
    5 mM 0.5270 mL 2.6352 mL 5.2704 mL
    10 mM 0.2635 mL 1.3176 mL 2.6352 mL
    *Please refer to the solubility information to select the appropriate solvent.
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (6.59 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (6.59 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (6.59 mM); Clear solution

    *All of the co-solvents are provided by MCE.

    The activity of purified human PIM-1, PIM-2 and PIM-3 enzymes on substrate FL-Ahx-Bad (FITC-(AHX)RSRHSSYPAGT-COOH) is determined using a mobility shift assay on a Caliper LC3000 reader. The PIM-1 assay is performed in a 12 mL reaction containing 50 mM HEPES (pH 7.5), 1 mM DTT, 0.01% Tween 20, 50 mg/mL BSA, 10 mM MgCl2, 1.5 mM FL-Ahx-Bad peptide, 100 mM ATP, 2.5 nM PIM-1 and various amount of inhibitor. The reaction is quenched after 90 minute incubation at 25°C with 5 mL of stop mix consisting of 100 mM HEPES, 121 mM EDTA, 0.8% Coating Reagent 3 and 0.01% Tween 20. The ATP and enzyme concentrations for the PIM-2 assay are 5 mM and 2.5 nM, respectively, while 50 mM of ATP and 0.33 nM of enzyme is used for PIM-3 assays. For high [ATP] screenings, 5 mM ATP is used with 0.67 nM enzyme for both PIM-1 and PIM-2 or 0.11 nM PIM-3. Fluorescence of phosphorylated and unphosphorylated substrate is detected and a ratiometric value is calculated to determine percent turnover. IC50 values are determined from dose-response data using IDBS ActivityBase software.

    MCE はこれらの方法の精度を確認していません。 こちらは参照専用です。


    MOLM-16 cells, purchased from DSMZ and cultured in RPMI containing 10% fetal bovine serum (FBS) and 1% L-glutamine, are plated at 20,000 cells per well in 96 well plates overnight. Cells are treated for 72 hours with compound or control vehicle (dimethyl sulfoxide) and cell viability is measured after the addition of Cell Titer-Blue for 4 hours at 37°C and reading of fluorescence on a Tecan Infinite® 200. The GI50 is determined by calculating growth at each dose relative to vehicle treated cells and cell viability at the time of treatment.

    MCE はこれらの方法の精度を確認していません。 こちらは参照専用です。


    純度: 99.76%

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    AZD1208AZD 1208AZD-1208PimAutophagyApoptosisPim kinasesInhibitorinhibitorinhibit



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