Azetidine-2-carboxylic acid

Name: Azetidine-2-carboxylic acid
Brand: MedChemExpress
SKU: HY-75308
Rating: 4.5 (1 reviews)

製品番号: HY-75308 純度: 98.0%: Data Sheet SDS COA 取扱説明書
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Azetidine-2-carboxylic acid is a non proteinogenic amino acid homologue of proline. Found in common beets. Azetidine-2-carboxylic acid can be misincorporated into proteins in place of proline in many species, including humans. Toxic and teratogenic agent.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Azetidine-2-carboxylic acid 構造式

CAS 番号 : 2517-04-6

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 38	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 38	在庫あり	Estimated Time of Arrival: December 31
Solid
1 g	$35	在庫あり	Estimated Time of Arrival: December 31
5 g	$85	在庫あり	Estimated Time of Arrival: December 31
10 g	$135	在庫あり	Estimated Time of Arrival: December 31
25 g	$270	在庫あり	Estimated Time of Arrival: December 31
50 g	$458	在庫あり	Estimated Time of Arrival: December 31
> 100 g		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Other Forms of Azetidine-2-carboxylic acid:

(R)-Azetidine-2-carboxylic acid 在庫あり
Azetidine-2-carboxylic acid-d₄ お問い合わせ

顧客検証

•EMBO Rep. 2024 Oct;25(10):4488-4514. [Abstract]

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•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

体外実験

Azetidine-2-carboxylic acid (375-5oo μg per day) is incorporated into the collagen synthesized by chick embryo cartilage in vitro^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

101.10

分子式

C₄H₇NO₂

CAS 番号

2517-04-6

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1NCC1

Structure Classification

Amino acids

Initial Source

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

H₂O : 50 mg/mL (494.56 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	9.8912 mL	49.4560 mL	98.9120 mL
5 mM	1.9782 mL	9.8912 mL	19.7824 mL
10 mM	0.9891 mL	4.9456 mL	9.8912 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (494.56 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 98.0%

Select Batch:

データシート (274 KB) SDS (393 KB)

COA (250 KB) HNMR (233 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Rubenstein E, et al. Azetidine-2-carboxylic acid in the food chain. Phytochemistry. 2009 Jan;70(1):100-4. [Content Brief]

[2]. Rubenstein E, et al. Misincorporation of the proline analog azetidine-2-carboxylic acid in the pathogenesis of multiple sclerosis: a hypothesis. J Neuropathol Exp Neurol. 2008 Nov;67(11):1035-40. [Content Brief]

[3]. Lane JM, et al. Effect of the proline analogue azetidine-2-carboxylic acid on collagen synthesis in vivo. I. Arrest of collagen accumulation in growing chick embryos. Biochim Biophys Acta. 1971 Jun 29;236(3):517-27. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	9.8912 mL	49.4560 mL	98.9120 mL	247.2799 mL
	5 mM	1.9782 mL	9.8912 mL	19.7824 mL	49.4560 mL
	10 mM	0.9891 mL	4.9456 mL	9.8912 mL	24.7280 mL
	15 mM	0.6594 mL	3.2971 mL	6.5941 mL	16.4853 mL
	20 mM	0.4946 mL	2.4728 mL	4.9456 mL	12.3640 mL
	25 mM	0.3956 mL	1.9782 mL	3.9565 mL	9.8912 mL
	30 mM	0.3297 mL	1.6485 mL	3.2971 mL	8.2427 mL
	40 mM	0.2473 mL	1.2364 mL	2.4728 mL	6.1820 mL
	50 mM	0.1978 mL	0.9891 mL	1.9782 mL	4.9456 mL
	60 mM	0.1649 mL	0.8243 mL	1.6485 mL	4.1213 mL
	80 mM	0.1236 mL	0.6182 mL	1.2364 mL	3.0910 mL
	100 mM	0.0989 mL	0.4946 mL	0.9891 mL	2.4728 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.