(R)-Azetidine-2-carboxylic acid
Based on 1 Customer Validation
(R)-Azetidine-2-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). (R)-Azetidine-2-carboxylic acid is also a alkyl chain-based PROTAC linker that can be
For research use only. We do not sell to patients.
- Purity: 99.62%
- CAS No.: 7729-30-8
- Formula: C4H7NO2
- Molecular Weight:101.10
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-77475
1-Cbz-3-Hydroxyazetidine
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HY-W004868
1-Cbz-azetidine-3-carboxylic acid
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HY-40144
Azetidin-3-ol hydrochloride
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HY-W011277
Fmoc-azetidine-3-carboxylic acid
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HY-W052600
Ethyl azetidine-3-carboxylate hydrochloride
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HY-16438
RRx-001
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HY-W050044
L-Azetidine-2-carboxylic acid
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HY-40146
tert-Butyl 3-oxoazetidine-1-carboxylate
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HY-75308
Azetidine-2-carboxylic acid
All PROTAC Linkers Isoforms
More
Biological Activity
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Non-cleavable Linker |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 7729-30-8
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Appearance Solid
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Molecular Weight 101.10
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Formula C4H7NO2
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Color White to off-white
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SMILES
O=C([C@@H]1NCC1)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
H2O : ≥ 175 mg/mL (1730.96 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 9.8912 mL | 49.4560 mL | 98.9120 mL | 247.2799 mL |
| 5 mM | 1.9782 mL | 9.8912 mL | 19.7824 mL | 49.4560 mL | |
| 10 mM | 0.9891 mL | 4.9456 mL | 9.8912 mL | 24.7280 mL | |
| 15 mM | 0.6594 mL | 3.2971 mL | 6.5941 mL | 16.4853 mL | |
| 20 mM | 0.4946 mL | 2.4728 mL | 4.9456 mL | 12.3640 mL | |
| 25 mM | 0.3956 mL | 1.9782 mL | 3.9565 mL | 9.8912 mL | |
| 30 mM | 0.3297 mL | 1.6485 mL | 3.2971 mL | 8.2427 mL | |
| 40 mM | 0.2473 mL | 1.2364 mL | 2.4728 mL | 6.1820 mL | |
| 50 mM | 0.1978 mL | 0.9891 mL | 1.9782 mL | 4.9456 mL | |
| 60 mM | 0.1649 mL | 0.8243 mL | 1.6485 mL | 4.1213 mL | |
| 80 mM | 0.1236 mL | 0.6182 mL | 1.2364 mL | 3.0910 mL | |
| 100 mM | 0.0989 mL | 0.4946 mL | 0.9891 mL | 2.4728 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
(R)-Azetidine-2-carboxylic acid Related Classifications
HY-W017755 Related Classifications
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