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Azoramide 

Cat. No.: HY-18705 Purity: >98.0%
Handling Instructions

Azoramide is a small-molecule modulator of the unfolded protein response with antidiabetic activity.

For research use only. We do not sell to patients.

Azoramide Chemical Structure

Azoramide Chemical Structure

CAS No. : 932986-18-0

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 78 In-stock
Estimated Time of Arrival: December 31
50 mg USD 312 In-stock
Estimated Time of Arrival: December 31
100 mg USD 552 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE Azoramide

    Azoramide purchased from MCE. Usage Cited in: Stem Cell Res Ther. 2018 Mar 9;9(1):57.

    Western blot of Runx2 protein in C3H10T1/2 cells subjected to 15 μM Azoramide.
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    Description

    Azoramide is a small-molecule modulator of the unfolded protein response with antidiabetic activity. in vitro: Azoramide is a dual-function endoplasmic reticulum (ER) modulator. Azoramide improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress in multiple systems. Azoramide regulates ER folding and secretion capacity without inducing ER stress. Azoramide might have the protective effects of enhancing chaperone expression and reducing protein synthesis without inducing cytotoxicity and apoptosis. in vivo: Azoramide exhibits potent antidiabetic efficacy in two independent mouse models of obesity by improving insulin sensitivity and pancreatic β cell function. Azoramide improves glucose homeostasis in mice with genetic obesity. Azoramide improves glucose homeostasis in mice with diet-induced obesity.

    Molecular Weight

    308.83

    Formula

    C₁₅H₁₇ClN₂OS

    CAS No.

    932986-18-0

    SMILES

    CCCC(NCCC1=CSC(C2=CC=C(Cl)C=C2)=N1)=O

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 30 mg/mL (97.14 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.2380 mL 16.1901 mL 32.3803 mL
    5 mM 0.6476 mL 3.2380 mL 6.4761 mL
    10 mM 0.3238 mL 1.6190 mL 3.2380 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References

    Purity: >98.0%

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    Product Name:
    Azoramide
    Cat. No.:
    HY-18705
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