1. GPCR/G Protein
  2. Glucagon Receptor

BETP 

Cat. No.: HY-103546 Purity: 99.28%
Handling Instructions

BETP is an agonist of glucagon-like peptide-1 (GLP-1) receptor, with EC50s of 0.66 and 0.755 μM for human and rat GLP-1 receptor, respectively.

For research use only. We do not sell to patients.

BETP Chemical Structure

BETP Chemical Structure

CAS No. : 1371569-69-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 110 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
5 mg USD 100 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
10 mg USD 170 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
25 mg USD 340 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
50 mg USD 610 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
100 mg USD 990 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

BETP is an agonist of glucagon-like peptide-1 (GLP-1) receptor, with EC50s of 0.66 and 0.755 μM for human and rat GLP-1 receptor, respectively.

IC50 & Target

EC50: 0.66 μM (Human GLP-1 receptor), 0.755 μM (Rat GLP-1 receptor)[1]

In Vitro

BETP is a GLP-1 receptor agonist, with EC50s of 0.66 and 0.755 μM for human and rat GLP-1 receptor, respectively. BETP (Compound B) is inactive in cells expressing the GLP-2, GIP, PTH, or glucagon receptors. BETP (1-10 μM) enhances insulin secretion in normal and diabetic human islets. In addition, BETP in combination with GLP-1 shows additive effects on increasing GLP-1 receptor signaling[1]. BETP increases the potency of oxyntomodulin by 10-fold (EC50 of 80 pM). GLP-1 does not change the potencies and efficacies of both oxyntomodulin and glucagon at the glucagon receptor. BETP (0-30 μM) increases the binding affinity of oxyntomodulin for the GLP-1 receptor[2].

In Vivo

BETP has insulinotropic effect in SD rats. BETP (10 mg/kg, jugular vein cannula) exhibits insulin secretagogue activity in the intravenous glucose tolerance test (IVGTT) model. BETP (10 mg/kg, i.v.)-treated rats need 20% higher glucose infusion rates and demonstrates higher plasma insulin levels in SD rat hyperglycemic clamp model[1]. BETP (5 mg/kg) enhances oxyntomodulin-stimulated insulin secretion[2].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.4605 mL 12.3025 mL 24.6051 mL
5 mM 0.4921 mL 2.4605 mL 4.9210 mL
10 mM 0.2461 mL 1.2303 mL 2.4605 mL
Please refer to the solubility information to select the appropriate solvent.
Animal Administration
[1]

BETP is formulated in dosing solution containing 10% ethanol/solutol, 20% polyethylene glycol-400, and 70% PBS (pH 7.4)[1].

Rats[1]
The IVGTT studies are performed. Male SD rats are group-housed three per cage in polycarbonate cages with filter tops. Rats are maintained on a 12:12 h light-dark cycle (lights on at 6:00 a.m.) at 21°C and receive diet and deionized water ad libitum. Rats are fasted overnight and anesthetized with 60 mg/kg pentobarbital for the duration of the experiment. For glucose and compounds (BETP, etc.) administration, a catheter with a diameter of 0.84 mm is inserted into the jugular vein. For rapid blood collection, a larger catheter with 1.02-mm diameter is inserted into the carotid artery. Blood is collected for glucose and insulin levels at time 0, 2, 4, 6, 10, and 20 min after intravenous administration of the BETP which is immediately followed by an intravenous glucose bolus of 0.5 g/kg. Plasma levels of glucose and insulin are determined[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

406.42

Formula

C₂₀H₁₇F₃N₂O₂S

CAS No.

1371569-69-5

SMILES

FC(C1=CC(C2=CC=CC(OCC3=CC=CC=C3)=C2)=NC(S(CC)=O)=N1)(F)F

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO; Methanol: ≥83.3 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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BETP
Cat. No.:
HY-103546
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