2. Immunology/Inflammation
  3. P-selectin L-Selectin E-Selectin
  4. Bimosiamose

Bimosiamose  (Synonyms: TBC-1269)

製品番号: HY-106139 純度: 98.82%
COA 取扱説明書 Technical Support

Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose has anti-inflammatory effects.

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Bimosiamose

Bimosiamose 構造式

CAS 番号 : 187269-40-5

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 376 在庫あり
Solution
10 mM * 1 mL in DMSO USD 376 在庫あり
Solid
1 mg $66 在庫あり
5 mg $198 在庫あり
10 mg $300 在庫あり
25 mg $600 在庫あり
50 mg $950 在庫あり
100 mg $1600 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 4 publication(s) in Google Scholar

Other Forms of Bimosiamose:

Bimosiamose 関連抗体

Top Publications Citing Use of Products

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose has anti-inflammatory effects[1].

IC50 & Target

IC50: 88 μM (E-selectin), 20 μM (P-selectin), 86 μM (L-selectin)[1]
Cellular Effect
Cell Line Type Value Description References
HL-60 IC50
70 μM
Compound: TBC-1269
Inhibition of P-selectin in human HL-60 cells
Inhibition of P-selectin in human HL-60 cells
[PMID: 20718494]
HL-60 IC50
70 μM
Compound: TBC1269
Inhibition of P-selectin-mediated adhesion of HL60 cells
Inhibition of P-selectin-mediated adhesion of HL60 cells
[PMID: 17201408]
体外実験

Bimosiamose (TBC-1269) operates by inhibiting neutrophil recruitment to the site of inflammation through blocking the initial rolling phase of recruitment. Bimosiamose (TBC-1269) inhibits cell recruitment and does not possess any cytotoxic effect on neutrophils[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bimosiamose 関連抗体
体内実験

Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment shows a significant increase in survival. Best overall survival, 70%, is observed when TBC-1269 is administered 15 minutes before reperfusion, and also shows a marked decrease in liver enzyme levels at 6 hours after reperfusion. Neutrophil migration is also significantly ameliorated (81%). The histologic damage scores is also improved[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats (200-225g) with ischemia and reperfusion (I/R)[1]
Dosage: 25 mg/kg
Administration: Intravenous injection
Result: Showed a significant increase in survival compared with controls.
臨床実験
分子量

862.91

分子式

C46H54O16
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

OC[C@H]([C@@H](O)[C@H](O)[C@@H]1O)O[C@@H]1OC(C=C2)=C(C3=CC(CC(O)=O)=CC=C3)C=C2CCCCCCC(C=C4)=CC(C5=CC(CC(O)=O)=CC=C5)=C4O[C@H]6O[C@@H]([C@@H](O)[C@H](O)[C@@H]6O)CO
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (115.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

0.1 M NaOH : 25 mg/mL (28.97 mM; ultrasonic and adjust pH to 10 with NaOH)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1589 mL 5.7943 mL 11.5887 mL
5 mM 0.2318 mL 1.1589 mL 2.3177 mL
10 mM 0.1159 mL 0.5794 mL 1.1589 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  5% DMSO    40% PEG300    5% Tween-80    50% Saline

    Solubility: ≥ 2.5 mg/mL (2.90 mM); Clear solution

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: ≥99.0%

COA (250 KB) HNMR (201 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
0.1 M NaOH / DMSO 1 mM 1.1589 mL 5.7943 mL 11.5887 mL 28.9717 mL
5 mM 0.2318 mL 1.1589 mL 2.3177 mL 5.7943 mL
10 mM 0.1159 mL 0.5794 mL 1.1589 mL 2.8972 mL
15 mM 0.0773 mL 0.3863 mL 0.7726 mL 1.9314 mL
20 mM 0.0579 mL 0.2897 mL 0.5794 mL 1.4486 mL
25 mM 0.0464 mL 0.2318 mL 0.4635 mL 1.1589 mL
DMSO 30 mM 0.0386 mL 0.1931 mL 0.3863 mL 0.9657 mL
40 mM 0.0290 mL 0.1449 mL 0.2897 mL 0.7243 mL
50 mM 0.0232 mL 0.1159 mL 0.2318 mL 0.5794 mL
60 mM 0.0193 mL 0.0966 mL 0.1931 mL 0.4829 mL
80 mM 0.0145 mL 0.0724 mL 0.1449 mL 0.3621 mL
100 mM 0.0116 mL 0.0579 mL 0.1159 mL 0.2897 mL
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Bimosiamose Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bimosiamose187269-40-5TBC-1269TBC1269TBC 1269P-selectinL-SelectinE-SelectinCD62CD62LCD62EELAM1LECAM-2E-selectinL-selectinischemiareperfusionanti-inflammatoryneutrophilmigrationnonoligosaccharideInhibitorinhibitorinhibit

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製品名:
Bimosiamose
製品番号:
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