1. Others
  2. Others

CCF642 

Cat. No.: HY-100430 Purity: 98.02%
Handling Instructions

CCF642 is a novel PDI-inhibiting compound with antimyeloma activity.

For research use only. We do not sell to patients.

CCF642 Chemical Structure

CCF642 Chemical Structure

CAS No. : 346640-08-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 145 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 132 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 192 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 720 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 1020 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

CCF642 is a novel PDI-inhibiting compound with antimyeloma activity. The IC50 is 2.9 μmol/L. In vitro: CCF642 inhibit PDI reductase activity about 100-fold more potently than the structurally distinct established inhibitors PACMA 31 and LOC14. CCF642 causes acute ER stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release. In vivo: CCF642 displayed potent efficacy in an aggressive syngeneic mouse model of multiple myeloma and prolonged the lifespan of C57BL/KaLwRij mice engrafted with 5TGM1-luc myeloma, an effect comparable to the first-line multiple myeloma therapeutic bortezomib. CCF642 can be given intravenously without injection reactions in mice with 10 mg/kg.

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.6424 mL 13.2118 mL 26.4236 mL
5 mM 0.5285 mL 2.6424 mL 5.2847 mL
10 mM 0.2642 mL 1.3212 mL 2.6424 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

378.45

Formula

C₁₅H₁₀N₂O₄S₃

CAS No.

346640-08-2

SMILES

O=C1N(C2=CC=C(OC)C=C2)C(S/C1=C/C3=CC=C([N+]([O-])=O)S3)=S

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 30 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
CCF642
Cat. No.:
HY-100430
Quantity: