346640-08-2
346640-08-2
Chemical Structure
CCF642
- CAS No.: 346640-08-2
- Formula:C15H10N2O4S3
- Molecular Weight:378.45
IUPAC Name: (E)-3-(4-methoxyphenyl)-5-((5-nitrothiophen-2-yl)methylene)-2-thioxothiazolidin-4-one
InChIKey: SPYIETQLOVDJCF-XYOKQWHBSA-N
SMILES: O=C1N(C2=CC=C(OC)C=C2)C(S/C1=C/C3=CC=C([N+]([O-])=O)S3)=S
Biological Activity: CCF642 is a potent protein disulfide isomerases (PDI) inhibitor with an IC50 of 2.9 μM. CCF642 causes acute endoplasmic reticulum (ER) stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release. CCF642 has broad anti-multiple myeloma activity[1].
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CCF642 | 98.0% | CCF642 is a potent protein disulfide isomerases (PDI) inhibitor with an IC50 of 2.9 μM. CCF642 causes acute endoplasmic reticulum (ER) stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release. CCF642 has broad anti-multiple myeloma activity. | ||||||||||||||||||||
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CCF642 (Standard) | ≥98% | CCF642 (Standard) is the analytical standard of CCF642 (HY-100430). This product is intended for research and analytical applications. CCF642 is a potent protein disulfide isomerases (PDI) inhibitor with an IC50 of 2.9 μM. CCF642 causes acute endoplasmic reticulum (ER) stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release. CCF642 has broad anti-multiple myeloma activity. | ||||||||||||||||||||
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References
Keywords
