CSC-6
CSC-6 is a NLRP3 inhibitor. CSC-6 can significantly inhibit IL-1β secreted by PMATHP-1 cells with an IC50 value of 2.3 μM. CSC-6 specifically binds NLRP3 and inhibits NLRP3 activation by blocking ASC oligomerization during NLRP3 assembly. CSC-6 effectively reduces the symptoms of NLRP3 overactivation-mediated sepsis and gout in mouse models.
For research use only. We do not sell to patients.
- CAS No.: 354559-44-7
- Formula: C18H12F3NO2S2
- Molecular Weight:395.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 2.3 μM (inhibit IL-1β secreted by PMATHP-1 cells)[1]
Chemical Information
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CAS No. 354559-44-7
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Molecular Weight 395.42
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Formula C18H12F3NO2S2
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SMILES
COC1=CC=C(N2C(S/C(C2=O)=C/C3=C(C(F)(F)F)C=CC=C3)=S)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CSC-6 Related Classifications
HY-161072 Related Classifications
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