PDI

By Targets:	PDI (13) Antibiotic (3) Apoptosis (3) Bacterial (3) Biochemical Assay Reagents (1) HIV (1) Liposome (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (1) Infection (3) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (2)
Click Chemistry:	Alkynes (1)

Targets Recommended: PDI

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W107464

G6PDi-1	PDI	Metabolic Disease Inflammation/Immunology
G6PDi-1 is a reversible and non-competitive glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC₅₀ of 0.07 μM for human G6PD. G6PDi-1 depletes NADPH most strongly in lymphocytes. G6PDi-1 markedly decreases inflammatory cytokine production in T cells .

HY-110172

PDI-IN-1

PDI Cancer

PDI-IN-1 (Compound P1) is a cell-permeable human protein disulfide isomerase (PDI) inhibitor with an IC₅₀ of 1.7 μM. PDI-IN-1 has anti-cancer activity.
HY-163351

PDI-IN-2

PDI Cancer

PDI-IN-2 (Compound 22) is a PDI or recombinant PDI inhibitor with IC₅₀ values of 0.62 and 0.63 μM, respectively. PDI-IN-2 has antitumor activity .
HY-124866

PDI-IN-3

PDI Neurological Disease

PDI-IN-3 (compound 16F16) is a protein disulfide isomerase (PDI) inhibitor. PDI-IN-3 inhibits cell viability .

PDI-IN-1	PDI	Cancer
PDI-IN-1 (Compound P1) is a cell-permeable human protein disulfide isomerase (PDI) inhibitor with an IC₅₀ of 1.7 μM. PDI-IN-1 has anti-cancer activity.

PDI-IN-2	PDI	Cancer
PDI-IN-2 (Compound 22) is a *PDI* or recombinant *PDI* inhibitor with IC₅₀ values of 0.62 and 0.63 μM, respectively. PDI-IN-2 has antitumor activity .

PDI-IN-3	PDI	Neurological Disease
PDI-IN-3 (compound 16F16) is a protein disulfide isomerase (PDI) inhibitor. PDI-IN-3 inhibits cell viability .

HY-W250110B

*Polyethylenimine (linear, average Mn 2100, PDI<1.3)* PEI (linear, average Mn 2100, PDI<1.3)	Liposome	Cancer
Polyethylenimine (PEI) (linear, average Mn 2100, PDI<1.3), a cationic polymer, is a non-viral gene delivery vector, especially for oligonucleotide delivery .

HY-114086

ML359	PDI	Cardiovascular Disease
ML359 is a potent, selctive and reversible inhibitor of protein disulfide isomerase (PDI), with an IC₅₀ of 250 nM. ML359 can prevent thrombus formation in vivo .

HY-100430

CCF642	Apoptosis PDI	Cancer
CCF642 is a potent protein disulfide isomerases (PDI) inhibitor with an IC₅₀ of 2.9 μM. CCF642 causes acute endoplasmic reticulum (ER) stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release. CCF642 has broad anti-multiple myeloma activity .

HY-111117

3-Methyltoxoflavin

1 Publications Verification

PDI Cancer

3-Methyltoxoflavin is a potent Protein disulfide isomerase (PDI) inhibitor, with an IC₅₀ of 170 nM.
HY-125832

PBDB-T

Biochemical Assay Reagents Others

PBDB-T is a wide bandgap polymer donor in Perylene diimide (PDI)-based polymer solar cells (PSCs) .

3-Methyltoxoflavin 1 Publications Verification	PDI	Cancer
3-Methyltoxoflavin is a potent Protein disulfide isomerase (PDI) inhibitor, with an IC₅₀ of 170 nM.

PBDB-T	Biochemical Assay Reagents	Others
PBDB-T is a wide bandgap polymer donor in Perylene diimide (PDI)-based polymer solar cells (PSCs) .

HY-100433

PACMA 31
PACMA 31 is an irreversible, orally active protein disulfide isomerase (PDI) inhibitor with an IC₅₀ of 10 μM. PACMA 31 forms a covalent bond with the active site cysteines of PDI. PACMA 31 shows tumor targeting ability and significantly suppresses ovarian tumor growth without causing toxicity to normal tissues . PACMA 31 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-124786

Juniferdin	HIV	Cancer
Juniferdin is an inhibitor of Protein disulfide isomerase (PDI) (IC₅₀=3.5 μM), aiming to block HIV transmission. Juniferdin is cytotoxic, and also inhibits platelet aggregation .

HY-142127

Ribostamycin Vistamycin; SF-733	Bacterial Antibiotic PDI	Infection
Ribostamycin (Vistamycin) is a broad-spectrum aminoglycoside antibiotic. Ribostamycin is effective against Gram-Negative and Gram-Positive bacterial infection. Ribostamycin also inhibits the chaperone activity of *PDI* .

HY-B1228

Ribostamycin sulfate 1 Publications Verification Vistamycin sulfate	Bacterial Antibiotic PDI	Infection
Ribostamycin sulfate (Vistamycin sulfate) is a broad-spectrum antimicrobial, inhibits bacterial protein synthesis at the level of 30S and 50S ribosomal subunit binding, also inhibits the chaperone activity of protein disulfide isomerase (PDI), used in pharmacokinetic and nephrotoxicity studies

HY-107193

Bacitracin	Bacterial Antibiotic PDI	Infection Cancer
Bacitracin is a polypeptide antibiotic against staphylococcal and pathogenic protozoa infections. Bacitracin inhibits cell wall biosynthesis and permeability through binding to the undecaprenyl pyrophosphate. Bacitracin inhibits macromolecular synthesis. Bacitracin is also a protein disulfide isomerase (PDI) inhibitor .

HY-122895

E64FC26 1 Publications Verification	Apoptosis PDI	Cancer
E64FC26 is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC₅₀s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6, respectively. E64FC26 shows anti-myeloma activity .

HY-100432

LOC14 2 Publications Verification
LOC14 is a potent Protein disulfide isomerase (PDI) inhibitor with EC₅₀ and K_d values of 500 nM and 62 nM, respectively. LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding . LOC14 inhibits PDIA3 activity, decreases intramolecular disulfide bonds and subsequent oligomerization (maturation) of HA in lung epithelial cells .

HY-117570

KSC-34	PDI	Neurological Disease
KSC-34, a covalent modifier of protein disulfide isomerase A1 (PDIA1), is also a selective and potent a-site inhibitor of PDIA1 with an IC₅₀ of 3.5 μM. KSC-34 displays a 30-fold selectivity for a domain over a′ domain and displays high selectivity for PDIA1 in complex proteomes with minimal engagement of other members of the PDI family . KSC-34 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-122895A

(E/Z)-E64FC26	Apoptosis PDI	Cancer
(E/Z)-E64FC26 is a mixture complex of E-E64FC26 and Z-E64FC26. E64FC26 (E-E64FC26) is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC₅₀s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6. E64FC26 shows anti-myeloma activity .

Cat. No.	Product Name	Type

HY-W250110B

*Polyethylenimine (linear, average Mn 2100, PDI<1.3)* PEI (linear, average Mn 2100, PDI<1.3)	Drug Delivery
Polyethylenimine (PEI) (linear, average Mn 2100, PDI<1.3), a cationic polymer, is a non-viral gene delivery vector, especially for oligonucleotide delivery .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1228

Ribostamycin sulfate 1 Publications Verification Vistamycin sulfate	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Resistance Selection Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial Antibiotic PDI
Ribostamycin sulfate (Vistamycin sulfate) is a broad-spectrum antimicrobial, inhibits bacterial protein synthesis at the level of 30S and 50S ribosomal subunit binding, also inhibits the chaperone activity of protein disulfide isomerase (PDI), used in pharmacokinetic and nephrotoxicity studies

HY-107193

Bacitracin	Structural Classification Classification of Application Fields Anti-aging Source classification Anti-parasitic Antibacterial Disease Research Other Antibiotics Infection Plant Cell Culture Microorganisms Antibiotics Resistance Selection Disease Research Fields Cancer	Bacterial Antibiotic PDI
Bacitracin is a polypeptide antibiotic against staphylococcal and pathogenic protozoa infections. Bacitracin inhibits cell wall biosynthesis and permeability through binding to the undecaprenyl pyrophosphate. Bacitracin inhibits macromolecular synthesis. Bacitracin is also a protein disulfide isomerase (PDI) inhibitor .

HY-124786

Juniferdin	Isodon serra (Maximowicz) Kudo Structural Classification Terpenoids Sesquiterpenes Source classification Plants Umbelliferae	HIV
Juniferdin is an inhibitor of Protein disulfide isomerase (PDI) (IC₅₀=3.5 μM), aiming to block HIV transmission. Juniferdin is cytotoxic, and also inhibits platelet aggregation .

HY-142127

Ribostamycin Vistamycin; SF-733	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial Antibiotic PDI
Ribostamycin (Vistamycin) is a broad-spectrum aminoglycoside antibiotic. Ribostamycin is effective against Gram-Negative and Gram-Positive bacterial infection. Ribostamycin also inhibits the chaperone activity of *PDI* .

Species:	Human (6) Mouse (2)
Tag:	His (8)
Source:	HEK293 (4) Sf9 insect cells (1) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P71917

	P4HB Protein, Human (His) Cellular thyroid hormone binding protein; Cellular thyroid hormone-binding protein; Collagen prolyl 4 hydroxylase beta; Disulphide Isomerase; DSI; EC 5.3.4.1; ER protein 59; ERBA2L; ERp59; GIT; P4HB; P4Hbeta; p55; PDI; PDIA1; PDIA1_HUMAN; PDIR; PHDB; PO4DB; PO4HB; PROHB; Protocollagen hydroxylase; Thbp;	Human	E. coli
	The P4HB protein is a multifunctional entity that catalyzes disulfide bonding processes at the cell surface and within cells. As a reductase, it modifies outer surface proteins and participates in the formation of disulfide bonds in nascent proteins. P4HB Protein, Human (His) is the recombinant human-derived P4HB protein, expressed by E. coli , with N-6*His labeled tag. The total length of P4HB Protein, Human (His) is 490 a.a., with molecular weight of ~56 kDa.

HY-P74658

	P4HB Protein, Mouse (HEK293, His) Protein disulfide-isomerase; PDI; ERp59; p55; P4HB; PDIa1	Mouse	HEK293
	P4HB proteins are versatile and multifunctional, coordinating disulfide bond catalysis at the cell surface and inside the cell. It exhibits reductase activity, cleaves disulfide bonds, induces structural modifications, and functions as a chaperone to inhibit aggregation of misfolded proteins. P4HB Protein, Mouse (HEK293, His) is the recombinant mouse-derived P4HB protein, expressed by HEK293 , with C-His labeled tag. The total length of P4HB Protein, Mouse (HEK293, His) is 490 a.a., with molecular weight of 57-70 kDa.

HY-P71087

	P4HB Protein, Human (HEK293, His) Protein Disulfide-Isomerase; PDI; Cellular Thyroid Hormone-Binding Protein; Prolyl 4-Hydroxylase Subunit Beta; p55; P4HB; ERBA2L; PDI; PDIA1; PO4DB	Human	HEK293
	The P4HB protein is a multifunctional entity that catalyzes disulfide bonding processes at the cell surface and within cells. As a reductase, it modifies outer surface proteins and participates in the formation of disulfide bonds in nascent proteins. P4HB Protein, Human (HEK293, His) is the recombinant human-derived P4HB protein, expressed by HEK293 , with C-6*His labeled tag. The total length of P4HB Protein, Human (HEK293, His) is 488 a.a., with molecular weight of ~58.9 kDa.

HY-P78738

	PADI2 Protein, Human (HEK293, His) PADI2; PAD-H19; KIAA0994; PAD2; PDI2	Human	HEK293
	PADI2 Protein, an enzyme, plays a crucial role in post-translational modifications of proteins. Dysregulation of PADI2 Protein has been associated with autoimmune disorders and inflammatory diseases. Targeting PADI2 Protein may offer potential therapeutic interventions in these conditions by modulating protein modifications, suppressing autoimmune responses, and managing inflammatory disorders. PADI2 Protein, Human (HEK293, His) is the recombinant human-derived PADI2 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of PADI2 Protein, Human (HEK293, His) is 665 a.a., with molecular weight of 66-85 kDa.

HY-P78767

	PADI2 Protein, Mouse (HEK293, His) PADI2; PAD-H19; KIAA0994; PAD2; PDI2	Mouse	HEK293
	Padi2 Protein functions as an enzyme that catalyzes the deimination process, specifically targeting arginine residues within proteins. PADI2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived PADI2 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of PADI2 Protein, Mouse (HEK293, His) is 673 a.a., with molecular weight of 66-88 kDa.

HY-P77121

	PADI4 Protein, Human (sf9, His) Protein-Arginine Deiminase Type-4; HL-60 PAD; Peptidylarginine Deiminase IV; PADI5; PDI5	Human	Sf9 insect cells
	PADI4 is a hydrolase that converts arginine residues in histones to citrulline. PADI4 promotes tumor progression by up-regulating the cytokine receptor CXCR2. PADI4 can also cause inflammation and immune responses. PADI4 Protein, Human (sf9, His) is the recombinant human-derived PADI4 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of PADI4 Protein, Human (sf9, His) is 663 a.a., with molecular weight of ~76.3 KDa.

HY-P701030

	PADI4 Protein, Human (Biotinylated, His) Protein-arginine deiminase type-4; HL-60 PAD; HL60 PAD; HL-60; PAD; PAD4; PADI5; PDI5	Human	E. coli
	The PADI4 protein catalyzes the citrullination of arginine residues in proteins such as histones, contributing to the histone code and stem cell regulation. PADI4 Protein, Human (Biotinylated, His) is the recombinant human-derived PADI4 protein, expressed by E. coli , with N-His labeled tag. The total length of PADI4 Protein, Human (Biotinylated, His) is 663 a.a., with molecular weight of 76.6 kDa.

HY-P70990

	PADI4 Protein, Human (His) Protein-Arginine Deiminase Type-4; HL-60 PAD; Peptidylarginine Deiminase IV; Protein-arginine Deiminase type IV; PADI4; PADI5; PDI5	Human	E. coli
	PADI4 is a hydrolase that converts arginine residues in histones to citrulline. PADI4 promotes tumor progression by up-regulating the cytokine receptor CXCR2. PADI4 can also cause inflammation and immune responses. PADI4 Protein, Human (His) is the recombinant human-derived PADI4 protein, expressed by E. coli , with N-6*His labeled tag. The total length of PADI4 Protein, Human (His) is 663 a.a., with molecular weight of 71-78 kDa.


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Application	Reactivity

HY-P81758

P4HB Antibody (YA1503)

P4HB; DSI; ERBA2L; GIT; P4Hbeta; PDI; PDIA1; PHDB; PO4DB; PO4HB; PROHB
WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat
HY-P82048

ERp29 Antibody (YA1793)

ERp28; ERP29_HUMAN; ERp31; HEL S 107; PDI-DB; PDIA9
WB, IHC-P, ICC/IF Human, Mouse, Rat

Cat. No.	Product Name		Classification

HY-117570

KSC-34		Alkynes
KSC-34, a covalent modifier of protein disulfide isomerase A1 (PDIA1), is also a selective and potent a-site inhibitor of PDIA1 with an IC₅₀ of 3.5 μM. KSC-34 displays a 30-fold selectivity for a domain over a′ domain and displays high selectivity for PDIA1 in complex proteomes with minimal engagement of other members of the PDI family . KSC-34 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Antibodies

Click Chemistry

PDI

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Recombinant Proteins

Antibodies

Click Chemistry

Natural
Products