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PACMA 31 

Cat. No.: HY-100433 Purity: >99.0%
Handling Instructions

PACMA 31 is an irreversible, orally active protein disulfide isomerase (PDI) inhibitor with an IC50 of 10 μM. PACMA 31 forms a covalent bond with the active site cysteines of PDI. PACMA 31 shows tumor targeting ability and significantly suppresses ovarian tumor growth without causing toxicity to normal tissues.

For research use only. We do not sell to patients.

PACMA 31 Chemical Structure

PACMA 31 Chemical Structure

CAS No. : 1401089-31-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 275 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

PACMA 31 is an irreversible, orally active protein disulfide isomerase (PDI) inhibitor with an IC50 of 10 μM. PACMA 31 forms a covalent bond with the active site cysteines of PDI. PACMA 31 shows tumor targeting ability and significantly suppresses ovarian tumor growth without causing toxicity to normal tissues[1].

IC50 & Target

IC50: 10 μM (protein disulfide isomerase)[1]

In Vitro

PACMA 31 (0-10 μM; 24 hours) significantly inhibits colony formation in OVCAR-8 cells in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PACMA 31 (20-200 mg/kg; i.p.; daily for 62 days) suppresses tumor growth in human ovarian cancer mouse xenografts [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic mice (bearing OVCAR-8 cells)[1]
Dosage: 20-200 mg/kg
Administration: I.p., per day for the first 3 wk with 5-d on and 2-d off treatment cycles, and dose was escalated to 40 mg/kg per day for the next 7 d; p.o., the initial dose of 20 mg/kg per day was gradually increased by 20 mg/kg per day with each dose for 3 d before it was orally dosed at 200 mg/kg per day for an additional 32 d, increasing the dose from 20 to 200 mg/kg
Result: Compared with the control group, i.p. or per os administration of PACMA 31 significantly inhibited tumor growth by 85% and 65% at day 62, respectively.
Molecular Weight

430.47

Formula

C₂₁H₂₂N₂O₆S

CAS No.

1401089-31-3

SMILES

COC1=CC=C(N(C(C2=CC=CS2)C(NCC(OCC)=O)=O)C(C#C)=O)C(OC)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: >99.0%

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Keywords:

PACMA 31PACMA31PACMA-31OthersoralcovalentbondovariantumortoxicitycolonyathymicmiceInhibitorinhibitorinhibit

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PACMA 31
Cat. No.:
HY-100433
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