2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  4. PDI
  5. PDI Inhibitor

PDI Inhibitor

PDI Inhibitors (9):

Cat. No. Product Name Effect Purity
  • HY-107193
    Bacitracin
    		Inhibitor
    Bacitracin is a polypeptide antibiotic against staphylococcal and pathogenic protozoa infections. Bacitracin inhibits cell wall biosynthesis and permeability through binding to the undecaprenyl pyrophosphate. Bacitracin inhibits macromolecular synthesis. Bacitracin is also a protein disulfide isomerase (PDI) inhibitor.
  • HY-100430
    CCF642
    		Inhibitor ≥98.0%
    CCF642 is a potent protein disulfide isomerases (PDI) inhibitor with an IC50 of 2.9 μM. CCF642 causes acute endoplasmic reticulum (ER) stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release. CCF642 has broad anti-multiple myeloma activity.
  • HY-122895
    E64FC26
    		Inhibitor 98.10%
    E64FC26 is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6, respectively. E64FC26 shows anti-myeloma activity.
  • HY-124866
    PDI-IN-3
    		Inhibitor
    PDI-IN-3 (compound 16F16) is a protein disulfide isomerase (PDI) inhibitor. PDI-IN-3 inhibits cell viability.
  • HY-163351
    PDI-IN-2
    		Inhibitor
    PDI-IN-2 (Compound 22) is a PDI or recombinant PDI inhibitor with IC50 values of 0.62 and 0.63 μM, respectively. PDI-IN-2 has antitumor activity.
  • HY-110172
    PDI-IN-1
    		Inhibitor
    PDI-IN-1 (Compound P1) is a cell-permeable human protein disulfide isomerase (PDI) inhibitor with an IC50 of 1.7 μM. PDI-IN-1 has anti-cancer activity.
  • HY-B1228
    Ribostamycin sulfate
    		Inhibitor 99.84%
    Ribostamycin sulfate (Vistamycin sulfate) is a broad-spectrum antimicrobial, inhibits bacterial protein synthesis at the level of 30S and 50S ribosomal subunit binding, also inhibits the chaperone activity of protein disulfide isomerase (PDI), used in pharmacokinetic and nephrotoxicity studies.
  • HY-122895A
    (E/Z)-E64FC26
    		Inhibitor 98.09%
    (E/Z)-E64FC26 is a mixture complex of E-E64FC26 and Z-E64FC26. E64FC26 (E-E64FC26) is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6. E64FC26 shows anti-myeloma activity.
  • HY-142127
    Ribostamycin
    		Inhibitor
    Ribostamycin (Vistamycin) is a broad-spectrum aminoglycoside antibiotic. Ribostamycin is effective against Gram-Negative and Gram-Positive bacterial infection. Ribostamycin also inhibits the chaperone activity of PDI.