2285446-67-3
2285446-67-3
Chemical Structure
(E/Z)-E64FC26
- CAS No.: 2285446-67-3
- Formula:C19H23F3O2
- Molecular Weight:340.38
IUPAC Name: (E)-1-nonylidene-3-(trifluoromethyl)-1H-indene-5,6-diol
InChIKey: OWYMWLCFHDHVAH-UKTHLTGXSA-N
SMILES: OC1=CC2=C(/C(C=C2C(F)(F)F)=C/CCCCCCCC)C=C1O
Biological Activity: (E/Z)-E64FC26 is a mixture of the stereoisomers E-E64FC26 and Z-E64FC26, in which E-E64FC26 is the active component and acts as a potent PDI inhibitor. The IC50 values of E64FC26 (E-E64FC26) for PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6 are 0.6, 4.8, 33.1, 12.1, and 5.7 μM, respectively. By inhibiting PDI, (E/Z)-E64FC26 causes massive intracellular accumulation of misfolded polyubiquitinated proteins, thereby triggering strong endoplasmic reticulum stress and oxidative stress responses, which in turn induce apoptosis. (E/Z)-E64FC26 is used in research on multiple myeloma, ovarian cancer, and breast cancer[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(E/Z)-E64FC26 | 99.80% | (E/Z)-E64FC26 is a mixture of the stereoisomers E-E64FC26 and Z-E64FC26, in which E-E64FC26 is the active component and acts as a potent PDI inhibitor. The IC50 values of E64FC26 (E-E64FC26) for PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6 are 0.6, 4.8, 33.1, 12.1, and 5.7 μM, respectively. By inhibiting PDI, (E/Z)-E64FC26 causes massive intracellular accumulation of misfolded polyubiquitinated proteins, thereby triggering strong endoplasmic reticulum stress and oxidative stress responses, which in turn induce apoptosis. (E/Z)-E64FC26 is used in research on multiple myeloma, ovarian cancer, and breast cancer. | ||||||||||||||||||||
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Cardol diene | Cardol diene is a potent antiparasitic agent. Cardol diene shows schistosomicidal activity and inhibits cell viability. | |||||||||||||||||||||
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Daphnecinnamte B | Daphnecinnamte B is an active compound. | |||||||||||||||||||||
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Resorstatin | Resorstatin is a dialkylresorcinol that can be isolated from a liquid culture of Pseudomonas sp. Ki19. Resorstatin exhibits antimicrobial activity. | |||||||||||||||||||||
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3,4,5-Trihydroxycinnamic acid decyl ester | 99.44% | 3,4,5-Trihydroxycinnamic acid decyl ester is an excellent inhibitor of lipid absorption and accumulation, with anti-obesity properties. 3,4,5-Trihydroxycinnamic acid decyl ester is a pancreatic lipase inhibitor, with an EC50 of approximately 0.9 μM. | ||||||||||||||||||||
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Bilobol | 97.1% | Bilobol is a potent insecticide against Aedes aegypti with a LC50 of 7.67 mg/L. Bilobol also has antitumor activity. | ||||||||||||||||||||
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(E)-[10]-Shogaol | (E)--Shogaol is a 5-HT1A receptor partial agonist found in Zingiber officinale, with a Ki of 5.84 μM. (E)--Shogaol may be used in research on anxiety and depression. | |||||||||||||||||||||
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[10]-Shogaol (Standard) | ≥98% | -Shogaol (Standard) is the analytical standard of -Shogaol (HY-N2434). This product is intended for research and analytical applications. -Shogaol is an orally active antioxidant. -Shogaol can be extracted from ginger (Zingiber officinale). -Shogaol1 inhibits COX-2 with an IC50 value of 7.5 μM. -Shogaol inhibits the production of proinflammatory cytokines (IL-1β, IL-6). -Shogaol inhibits NF-κB phosphorylation. -Shogaol has anti-inflammatory effects. -Shogaol has anticancer effects against Docetaxel (HY-B0011)-resistant prostate cancer. -Shogaol exhibits larvicidal activity against L5 larvae of Angiostrongylus cantonensis. | ||||||||||||||||||||
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(E)-[8]-Shogaol | (E)--Shogaol is an isomer of -Shogaol (HY-N2435). -Shogaol is an orally active apoptosis inducer and growth inhibitor. -Shogaol induces apoptosis by promoting the expression of the pro-apoptotic protein Bad, antagonizing members of the Bcl-2 family, and activating the caspase cascade. -Shogaol also induces autophagy and endoplasmic reticulum stress by generating reactive oxygen species, depleting glutathione, and disrupting mitochondrial transmembrane potential. In addition, -Shogaol inhibits LPS-mediated production of inflammatory cytokines and sensitizes radioresistant gastric cancer cells to radiotherapy. -Shogaol is widely used in studies related to leukemia, colorectal cancer, gastric cancer, as well as LPS-induced sepsis or inflammation. | |||||||||||||||||||||
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n-Octyl caffeate | n-Octyl caffeate shows anti-cancer and apoptosis inducing activity in highly liver-metastatic murine colon 26-L5 carcinoma cell lines. | |||||||||||||||||||||
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N-Octanoyl dopamine | N-Octanoyl dopamine is superior to dopamine in protecting graft contractile function when administered to the heart transplant recipients from brain-dead donors. N-Octanoyl dopamine inhibits cytokine production in activated T-cells and diminishes MHC-class-II expression as well as adhesion molecules in IFNγ-stimulated endothelial cells. | |||||||||||||||||||||
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References
- [1]. Robinson RM, et al. Tuning isoform selectivity and bortezomib sensitivity with a new class of alkenyl indene PDI inhibitor. European journal of medicinal chemistry. 2020 Jan 15;186:111906.
- [2]. Liu W, et al. Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization. Leukemia. 2019 Mar;33(3):749-761.
- [3]. Xu S, et al. Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proceedings of the National Academy of Sciences of the United States of America. 2012 Oct 02;109(40):16348-53. [Content Brief]
- [4]. Daurio NA, et al. AMPK Activation and Metabolic Reprogramming by Tamoxifen through Estrogen Receptor-Independent Mechanisms Suggests New Uses for This Therapeutic Modality in Cancer Treatment. Cancer research. 2016 Jun 01;76(11):3295-306.
