2. Anti-infection Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Bacterial Antibiotic PDI
  4. Ribostamycin

Ribostamycin  (Synonyms: Vistamycin; SF-733)

Cat. No.: HY-142127 Purity: 99.89%
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Handling Instructions Technical Support

Ribostamycin (Vistamycin) is a broad-spectrum aminoglycoside antibiotic. Ribostamycin is effective against Gram-Negative and Gram-Positive bacterial infection. Ribostamycin also inhibits the chaperone activity of PDI.

For research use only. We do not sell to patients.

Ribostamycin

Ribostamycin Chemical Structure

CAS No. : 25546-65-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Solution
10 mM * 1 mL in Water In-stock
Solid
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Ribostamycin:

Ribostamycin Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Ribostamycin

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ribostamycin (Vistamycin) is a broad-spectrum aminoglycoside antibiotic. Ribostamycin is effective against Gram-Negative and Gram-Positive bacterial infection. Ribostamycin also inhibits the chaperone activity of PDI[1][2].

IC50 & Target

Aminoglycoside

 

In Vitro

Ribostamycin inhibits Borrelia burgdorferi with a MIC90 of 32 mg/L[2].
Ribostamycin (1-100 μM, 0-15 min) inhibits the chaperone activity of PDI[3].
Ribostamycin inhibits Escherichia coli strains with a MIC of 0.9-7.2 μM[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ribostamycin Related Antibodies

Cell Viability Assay[4]

Cell Line: Escherichia coli strains
Concentration: 0-64 μg/mL
Incubation Time: 14 h
Result: Inhibited Escherichia coli strains with a MIC of 0.9-7.2 μM.
In Vivo

Ribostamycin (40 mg/kg, intramuscular injection, per day for 14 days) causes little nephrotoxicity in rats(evaluated by urinalysis)[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

454.47

Formula

C17H34N4O10
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

NC[C@H]([C@H]([C@@H]([C@H]1N)O)O)O[C@@H]1O[C@H]([C@H](C[C@H]([C@@H]2O)N)N)[C@@H]2O[C@@H]3O[C@@H]([C@H]([C@H]3O)O)CO
Structure Classification
Initial Source

Streptomyces ribosidificus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (110.02 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2004 mL 11.0018 mL 22.0037 mL
5 mM 0.4401 mL 2.2004 mL 4.4007 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.2004 mL 11.0018 mL 22.0037 mL 55.0091 mL
5 mM 0.4401 mL 2.2004 mL 4.4007 mL 11.0018 mL
10 mM 0.2200 mL 1.1002 mL 2.2004 mL 5.5009 mL
15 mM 0.1467 mL 0.7335 mL 1.4669 mL 3.6673 mL
20 mM 0.1100 mL 0.5501 mL 1.1002 mL 2.7505 mL
25 mM 0.0880 mL 0.4401 mL 0.8801 mL 2.2004 mL
30 mM 0.0733 mL 0.3667 mL 0.7335 mL 1.8336 mL
40 mM 0.0550 mL 0.2750 mL 0.5501 mL 1.3752 mL
50 mM 0.0440 mL 0.2200 mL 0.4401 mL 1.1002 mL
60 mM 0.0367 mL 0.1834 mL 0.3667 mL 0.9168 mL
80 mM 0.0275 mL 0.1375 mL 0.2750 mL 0.6876 mL
100 mM 0.0220 mL 0.1100 mL 0.2200 mL 0.5501 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Ribostamycin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ribostamycin25546-65-0Vistamycin SF-733SF733SF 733SF-733BacterialAntibioticPDIProtein Disulfide IsomerasesGram-PositiveGram-Negativebacterial infectionInhibitorinhibitorinhibit

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