Ribostamycin sulfate
Based on 1 publication(s) in Google Scholar
For research use only. We do not sell to patients.
- Purity: 99.55%
- CAS No.: 53797-35-6
- Formula: C17H36N4O14S
- Molecular Weight:552.55
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Ribostamycin sulfate
MoreAll Antibiotic Isoforms
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Biological Activity
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Aminoglycoside |
Ribostamycin sulfate can bind to purified bovine protein disulfide isomerase (PDI) with a dissociation constant of 319 μM; it can inhibit the chaperone activity of purified bovine PDI, but does not inhibit the autodegradation activity of purified bovine PDI[1].
Ribostamycin (0.25-64 μg/mL; 14 h) sulfate potently inhibits Haemophilus influenzae ATCC 49247 (MIC = 0.5 μM), Streptococcus pneumoniae ATCC 49619 (MIC = 7.2 μM), and three Escherichia coli strains (ATCC 4157, ATCC 12435, ATCC 10798; MIC range 0.9-7.2 μM), shows moderate activity against two other E. coli strains, and has very weak or no activity against Pseudomonas aeruginosa, Staphylococcus aureus, and Enterococcus faecalis strains in vitro[2].
Ribostamycin (0.25-64 μg/mL plus 2640 μM EDTA (HY-Y0682); 14 h) sulfate co-treatment with EDTA reduces the MIC of ribostamycin 8-fold against β-lactam-resistant Escherichia coli ATCC 35218, has no effect on its activity against E. coli ATCC 25922 or Pseudomonas aeruginosa ATCC 27853, and reduces its MIC against Staphylococcus aureus ATCC 12600 to <0.1 μM in vitro[2].
Ribostamycin (68 h) sulfate exhibits no cytotoxicity against HEK293 and MDCKII kidney cells[2].
Ribostamycin (72 h for MIC, 72 h exposure followed by 3-week subculture for MBC) sulfate shows no significant in vitro inhibitory or borreliacidal activity against 11 Borrelia burgdorferi sensu lato isolates[3].
Ribostamycin (500 μM-1 mM) sulfate forms linear oligomers that mediate the assembly of citrate-capped AuNPs (40 nm, 60 nm, 80 nm, 100 nm) into visible linear structures, with the most robust assemblies formed with 40 nm and 60 nm AuNPs[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 53797-35-6
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Appearance Solid
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Molecular Weight 552.55
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Formula C17H36N4O14S
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Color White to off-white
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SMILES
O=S(O)(O)=O.O[C@@H]([C@H](O)[C@@H](CN)O1)[C@@H](N)[C@@]1([H])O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@@]2([H])O[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
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Synonyms
Vistamycin sulfate
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Structure Classification
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Initial Source
Streptomyces ribosidicus
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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J Pharm Biomed Anal
Development and validation of a sensitive LC-MS/MS method without derivatization/ion-pairing agents for etimicin quantification in rat plasma, internal ear and kidney. [Abstract]2017 Nov 30:146:96-102. PMID: 28881316
Solvent & Solubility
H2O : 130 mg/mL (235.27 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (90.49 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (282 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
[2]. Kong J, et al. Exploration of Antibiotic Activity of Aminoglycosides, in Particular Ribostamycin Alone and in Combination With Ethylenediaminetetraacetic Acid Against Pathogenic Bacteria. Front Microbiol. 2020;11:1718. Published 2020 Jul 29. [Content Brief]
[3]. Hunfeld KP, et al. In vitro activity of mezlocillin, meropenem, aztreonam, vancomycin, teicoplanin, ribostamycin and fusidic acid against Borrelia burgdorferi. Int J Antimicrob Agents. 2001;17(3):203-208. [Content Brief]
[4]. Zheng T, et al. Linear self-assembly formation between gold nanoparticles and aminoglycoside antibiotics. Colloids Surf B Biointerfaces. 2018;164:185-191. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.8098 mL | 9.0490 mL | 18.0979 mL | 45.2448 mL |
| 5 mM | 0.3620 mL | 1.8098 mL | 3.6196 mL | 9.0490 mL | |
| 10 mM | 0.1810 mL | 0.9049 mL | 1.8098 mL | 4.5245 mL | |
| 15 mM | 0.1207 mL | 0.6033 mL | 1.2065 mL | 3.0163 mL | |
| 20 mM | 0.0905 mL | 0.4524 mL | 0.9049 mL | 2.2622 mL | |
| 25 mM | 0.0724 mL | 0.3620 mL | 0.7239 mL | 1.8098 mL | |
| 30 mM | 0.0603 mL | 0.3016 mL | 0.6033 mL | 1.5082 mL | |
| 40 mM | 0.0452 mL | 0.2262 mL | 0.4524 mL | 1.1311 mL | |
| 50 mM | 0.0362 mL | 0.1810 mL | 0.3620 mL | 0.9049 mL | |
| 60 mM | 0.0302 mL | 0.1508 mL | 0.3016 mL | 0.7541 mL | |
| 80 mM | 0.0226 mL | 0.1131 mL | 0.2262 mL | 0.5656 mL | |
| 100 mM | 0.0181 mL | 0.0905 mL | 0.1810 mL | 0.4524 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Ribostamycin sulfate Related Classifications
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