3097563-91-9
3097563-91-9
Chemical Structure
PDI-IN-5
- CAS No.: 3097563-91-9
- Formula:C19H16Cl2N4O2
- Molecular Weight:403.26
InChIKey: LZJNITMOCUMUAM-UHFFFAOYSA-N
SMILES: O=C(N1CC#CC(NCC)=O)C2=C(N=C1Cl)N(CC3=C(C=CC=C3)Cl)C=C2
Biological Activity: PDI-IN-5 (compound 30z) is an allosteric-covalent inhibitor targeting protein disulfide isomerase (PDI) with a 2-chloro-pyrrolopyrimidin-4-one scaffold, with an IC50 of 0.4 μM. PDI-IN-5 exhibits selectivity for ERp57 and GPX4, and inhibits glioblastoma. PDI-IN-5 can be used in glioblastoma-related research[1].
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PDI-IN-5 | PDI-IN-5 (compound 30z) is an allosteric-covalent inhibitor targeting protein disulfide isomerase (PDI) with a 2-chloro-pyrrolopyrimidin-4-one scaffold, with an IC50 of 0.4 μM. PDI-IN-5 exhibits selectivity for ERp57 and GPX4, and inhibits glioblastoma. PDI-IN-5 can be used in glioblastoma-related research. | |||||||||||||||||||||
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References
Keywords
