16408-78-9
Chemical Structure
Dicentrinone
- CAS No.: 16408-78-9
- Formula:C19H13NO5
- Molecular Weight:335.31
InChIKey: NEQVOBXBOFZEMR-UHFFFAOYSA-N
SMILES: O=C1C2=NC=CC3=CC4=C(C(C5=C1C=C(OC)C(OC)=C5)=C23)OCO4
Biological Activity: Dicentrinone is an orally active PDI inhibitor with an IC50 value of 43.95 μM. Dicentrinone directly binds to PDI and suppresses cell proliferation and reduces cancer cell viability. Dicentrinone elicits anti-inflammatory and antioxidant effects by suppressing leukocyte migration, plasma leakage and paw edema, and scavenging free radicals. Dicentrinone can be used in the research of hepatoma, rheumatism and arthritis[1][2][3].
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Dicentrinone | Dicentrinone is an orally active PDI inhibitor with an IC50 value of 43.95 μM. Dicentrinone directly binds to PDI and suppresses cell proliferation and reduces cancer cell viability. Dicentrinone elicits anti-inflammatory and antioxidant effects by suppressing leukocyte migration, plasma leakage and paw edema, and scavenging free radicals. Dicentrinone can be used in the research of hepatoma, rheumatism and arthritis. | |||||||||||||||||||||
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- [1]. Zhao M, et al. Dicentrine and dicentrinone isolated from Stephania tetrandrae Radix suppress HepG2 proliferation through inhibiting PDI activity. Rec Nat Prod. 2021;15(5):396-407.
- [2]. Paz WHP, et al. Structure-Based Molecular Networking for the Target Discovery of Oxahomoaporphine and 8-Oxohomoaporphine Alkaloids from Duguetia surinamensis. J Nat Prod. 2019 Aug 23;82(8):2220-2228. [Content Brief]
- [3]. do Santos RC, et al. Antioxidant, anti-rheumatic and anti-inflammatory investigation of extract and dicentrinone from Duguetia furfuracea (A. St.-Hil.) Benth. & Hook. f. J Ethnopharmacol. 2018 Jan 30;211:9-16. [Content Brief]
Keywords
