1461648-55-4
Chemical Structure
PDI-IN-1
- CAS. Nr.: 1461648-55-4
- Formula:C30H37N3O7S
- Molecular Weight:583.70
IUPAC Name: 4-((S)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)-3-oxo-3-(pent-4-yn-1-ylamino)propyl)phenyl ethenesulfonate
InChIKey: RNMDSOKRNOMQFX-UIOOFZCWSA-N
SMILES: O=C([C@@H](NC([C@@H](NC(OC(C)(C)C)=O)CC1=CC=CC=C1)=O)CC2=CC=C(C=C2)OS(=O)(C=C)=O)NCCCC#C
Biological Activity: PDI-IN-1 is a cell-permeable PDI covalent inhibitor with an IC50 of 1.7 μM against bovine PDI. PDI-IN-1 specifically modifies the Cys397 residue at the active site of human PDI, selectively labels endogenous PDI in living mammalian cancer cells, and effectively inhibits PDI-mediated insulin aggregation in vitro. PDI-IN-1 exhibits significant anti-tumor activity and inhibits the growth of various cancer cell lines[1].
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PDI-IN-1 | 99.92% | PDI-IN-1 is a cell-permeable PDI covalent inhibitor with an IC50 of 1.7 μM against bovine PDI. PDI-IN-1 specifically modifies the Cys397 residue at the active site of human PDI, selectively labels endogenous PDI in living mammalian cancer cells, and effectively inhibits PDI-mediated insulin aggregation in vitro. PDI-IN-1 exhibits significant anti-tumor activity and inhibits the growth of various cancer cell lines. | ||||||||||||||||||||
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Keywords
