Bacitracin
Based on 3 publication(s) in Google Scholar
Bacitracin is a polypeptide antibiotic against staphylococcal and pathogenic protozoa infections. Bacitracin inhibits cell wall biosynthesis and permeability through binding to the undecaprenyl pyrophosphate. Bacitracin inhibits macromolecular synthesis. Bacitracin is also a protein disulfide isomerase (PDI) inhibitor.
For research use only. We do not sell to patients.
- CAS No.: 1405-87-4
- Formula: C66H103N17O16S
- Molecular Weight:1422.69
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Bacitracin
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Customer Validation & Images
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Others
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WB
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WB
All Antibiotic Isoforms
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Biological Activity
Bacitracin (64 μg/mL, 24 h) together with Colistin shows antibacterial activity against S. aureus BA01611[1].
Bacitracin (64 μg/mL, 1 or 2 h) damages the cell surface to grape-like cell clusters, and the cell boundaries are faint and unclear[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:HCC model (MH134 cells implanted)[3]
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Dosage:0, 10, 50, and 100 mg/kg
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Administration:Intramuscular injection (i.m), daily for 12 consecutive days.
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Result:Decreased tumor volumes.
Decreased the percentage of PDI-stained vascular densities.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1405-87-4
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Appearance Solid
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Molecular Weight 1422.69
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Formula C66H103N17O16S
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Color White to light yellow
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SMILES
[Bacitracin]
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Initial Source
Tracey I strain of Bacillus subtilis
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (3)
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Journal Impact Factor
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Most Recent
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NPJ Biofilms Microbiomes
Gut microbiota dysbiosis-mediated ceramides elevation contributes to corticosterone-induced depression by impairing mitochondrial function. [Abstract]2024 Oct 28;10(1):111. PMID: 39468065 -
Bacitracin purchased from MedChemExpress. Usage Cited in: eFood. 2025 Oct 8.
The effects of C3G and Bacitracin on IDE-catalyzed fluorescence generation.
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Bacitracin purchased from MedChemExpress. Usage Cited in: Res Sq. 2025 Dec 3.
WB quantification of indicated proteins in MDA-MB-468 and HCC1954 cells treated with the P4HB inhibitor Bacitracin (0–4 mM) for 24 h.
Bacitracin purchased from MedChemExpress. Usage Cited in: Res Sq. 2025 Dec 3.
WB quantification of membrane and cytosolic proteins in MDA-MB-468 and HCC1954 cells treated with Bacitracin (2 mM) for 24 h.
Solvent & Solubility
H2O : 100 mg/mL (70.29 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (70.29 mM); Suspended solution; Need ultrasonic
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Si W, et al. Colistin Induces S. aureus Susceptibility to Bacitracin. Front Microbiol. 2018 Nov 20;9:2805. [Content Brief]
[3]. Yu SJ, et al. Enhancement of hexokinase II inhibitor-induced apoptosis in hepatocellular carcinoma cells via augmenting ER stress and anti-angiogenesis by protein disulfide isomerase inhibition. J Bioenerg Biomembr. 2012 Feb;44(1):101-15. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.7029 mL | 3.5145 mL | 7.0289 mL | 17.5723 mL |
| 5 mM | 0.1406 mL | 0.7029 mL | 1.4058 mL | 3.5145 mL | |
| 10 mM | 0.0703 mL | 0.3514 mL | 0.7029 mL | 1.7572 mL | |
| 15 mM | 0.0469 mL | 0.2343 mL | 0.4686 mL | 1.1715 mL | |
| 20 mM | 0.0351 mL | 0.1757 mL | 0.3514 mL | 0.8786 mL | |
| 25 mM | 0.0281 mL | 0.1406 mL | 0.2812 mL | 0.7029 mL | |
| 30 mM | 0.0234 mL | 0.1171 mL | 0.2343 mL | 0.5857 mL | |
| 40 mM | 0.0176 mL | 0.0879 mL | 0.1757 mL | 0.4393 mL | |
| 50 mM | 0.0141 mL | 0.0703 mL | 0.1406 mL | 0.3514 mL | |
| 60 mM | 0.0117 mL | 0.0586 mL | 0.1171 mL | 0.2929 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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