2. Anti-infection Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Bacterial Antibiotic PDI
  4. Bacitracin

Bacitracin is a polypeptide antibiotic against staphylococcal and pathogenic protozoa infections. Bacitracin inhibits cell wall biosynthesis and permeability through binding to the undecaprenyl pyrophosphate. Bacitracin inhibits macromolecular synthesis. Bacitracin is also a protein disulfide isomerase (PDI) inhibitor.

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Bacitracin Chemical Structure

Bacitracin Chemical Structure

CAS No. : 1405-87-4

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Based on 1 publication(s) in Google Scholar

Bacitracin Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Bacitracin is a polypeptide antibiotic against staphylococcal and pathogenic protozoa infections. Bacitracin inhibits cell wall biosynthesis and permeability through binding to the undecaprenyl pyrophosphate. Bacitracin inhibits macromolecular synthesis. Bacitracin is also a protein disulfide isomerase (PDI) inhibitor[1][2][3].

In Vitro

Bacitracin (64 μg/mL, 24 h) together with Colistin shows antibacterial activity against S. aureus BA01611[1].
Bacitracin (64 μg/mL, 1 or 2 h) damages the cell surface to grape-like cell clusters, and the cell boundaries are faint and unclear[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bacitracin Related Antibodies
In Vivo

Bacitracin (0-100 mg/kg, intramuscular injection, daily for 12 consecutive days) shows anti-tumor efficacy in HCC model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HCC model (MH134 cells implanted)[3]
Dosage: 0, 10, 50, and 100 mg/kg
Administration: Intramuscular injection (i.m), daily for 12 consecutive days.
Result: Decreased tumor volumes.
Decreased the percentage of PDI-stained vascular densities.
Clinical Trial
Molecular Weight

1422.69

Formula

C66H103N17O16S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

[Bacitracin]
Structure Classification
Initial Source

Tracey I strain of Bacillus subtilis
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (70.29 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7029 mL 3.5145 mL 7.0289 mL
5 mM 0.1406 mL 0.7029 mL 1.4058 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (70.29 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

COA (245 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.7029 mL 3.5145 mL 7.0289 mL 17.5723 mL
5 mM 0.1406 mL 0.7029 mL 1.4058 mL 3.5145 mL
10 mM 0.0703 mL 0.3514 mL 0.7029 mL 1.7572 mL
15 mM 0.0469 mL 0.2343 mL 0.4686 mL 1.1715 mL
20 mM 0.0351 mL 0.1757 mL 0.3514 mL 0.8786 mL
25 mM 0.0281 mL 0.1406 mL 0.2812 mL 0.7029 mL
30 mM 0.0234 mL 0.1171 mL 0.2343 mL 0.5857 mL
40 mM 0.0176 mL 0.0879 mL 0.1757 mL 0.4393 mL
50 mM 0.0141 mL 0.0703 mL 0.1406 mL 0.3514 mL
60 mM 0.0117 mL 0.0586 mL 0.1171 mL 0.2929 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Bacitracin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bacitracin1405-87-4BacterialAntibioticPDIProtein Disulfide IsomerasesStaphylococcalinfectionpathogenic protozoaHCCInhibitorinhibitorinhibit

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