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KSC-34 

Cat. No.: HY-117570
Handling Instructions

KSC-34 is a potent and site-selective inhibitor of PDIA1 (containing two active-site domains a and a′). KSC-34 displays a 30-fold selectivity for a domain over a′ domain and time-dependent inhibition of PDIA1 reductase activity. KSC-34 displays high selectivity for PDIA1 in complex proteomes with minimal engagement of other members of the PDI family.

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KSC-34 Chemical Structure

KSC-34 Chemical Structure

CAS No. : 2226201-97-2

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Description

KSC-34 is a potent and site-selective inhibitor of PDIA1 (containing two active-site domains a and a′). KSC-34 displays a 30-fold selectivity for a domain over a′ domain and time-dependent inhibition of PDIA1 reductase activity. KSC-34 displays high selectivity for PDIA1 in complex proteomes with minimal engagement of other members of the PDI family[1].

In Vitro

KSC-34 is a highly selective covalent modifier of PDIA1. KSC-34 displays time-dependent inhibition of PDIA1 reductase activity in vitro with a kinact/KI=9.66×103 M−1s−1, and is selective for PDIA1 over other members of the PDI family, and other cellular cysteine-containing proteins[1].

Molecular Weight

429.95

Formula

C₂₁H₂₈ClN₇O

CAS No.

2226201-97-2

SMILES

O=C(NCCNC1=NC(N(C)CCCCC2=CC=CC=C2)=NC(NCC#C)=N1)CCl

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

KSC-34KSC34KSC 34Othersselective,domainreductasetime-dependentInhibitorinhibitorinhibit

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