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ML359 

Cat. No.: HY-114086
Handling Instructions

ML359 is a potent, selctive and reversible inhibitor of protein disulfide isomerase (PDI), with an IC50 of 250 nM. ML359 can prevent thrombus formation in vivo.

For research use only. We do not sell to patients.

ML359 Chemical Structure

ML359 Chemical Structure

CAS No. : 1069858-99-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 418 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 418 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 380 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2850 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

ML359 is a potent, selctive and reversible inhibitor of protein disulfide isomerase (PDI), with an IC50 of 250 nM. ML359 can prevent thrombus formation in vivo[1][2].

IC50 & Target

IC50: 250 nM (protein disulfide isomerase)o[1]

In Vitro

ML359 是一种有效,选择性和可逆的蛋白质二硫键异构酶 (PDI) 抑制剂,IC50 值为 250 nM。ML359 可以抑制体内血栓形成。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ML359 inhibits of thrombus formation in a mouse laser injury model[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

417.93

Formula

C₂₃H₂₈ClNO₄

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (239.27 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3927 mL 11.9637 mL 23.9275 mL
5 mM 0.4785 mL 2.3927 mL 4.7855 mL
10 mM 0.2393 mL 1.1964 mL 2.3927 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.98 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.98 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.98 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
ML359
Cat. No.:
HY-114086
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