1069858-99-6
1069858-99-6
Chemical Structure
ML359
- CAS No.: 1069858-99-6
- Formula:C23H28ClNO4
- Molecular Weight:417.93
IUPAC Name: ethyl 1-(3-chloro-4-hydroxybenzyl)-4-(2-phenoxyethyl)piperidine-4-carboxylate
InChIKey: DCLHRRNJOZJGKD-UHFFFAOYSA-N
SMILES: O=C(C1(CCN(CC1)CC2=CC=C(C(Cl)=C2)O)CCOC3=CC=CC=C3)OCC
Biological Activity: ML359 is a potent, selctive and reversible inhibitor of protein disulfide isomerase (PDI), with an IC50 of 250 nM. ML359 can prevent thrombus formation in vivo[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ML359 | 98.32% | ML359 is a potent, selctive and reversible inhibitor of protein disulfide isomerase (PDI), with an IC50 of 250 nM. ML359 can prevent thrombus formation in vivo. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.83
HY-138934Bepristat 1a -
Similarity Score 0.65
HY-104006RCYM51010 (Standard) -
Similarity Score 0.57
HY-182389NLX-219 -
Similarity Score 0.57
HY-128346PQM130 -
Similarity Score 0.56
HY-118368L-742001 hydrochloride -
Similarity Score 0.56
HY-163369HDAC6-IN-35 -
Similarity Score 0.55
HY-184459MoTPS1-IN-2 -
Similarity Score 0.54
HY-101038AZK756326 dihydrochloride -
Similarity Score 0.54
HY-101038ZK 756326 -
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References
- [1]. Khodier C, et, al. Identification of ML359 as a Small Molecule Inhibitor of Protein Disulfide Isomerase. Probe Reports from the NIH Molecular Libraries Program. 2010-2013 Apr 12. [Content Brief]
- [2]. Bendapudi PK, et, al. ML359, a Small Molecule Inhibitor of Protein Disulfide Isomerase That Prevents Thrombus Formation and Inhibits Oxidoreductase but Not Transnitrosylase Activity. Blood (2014) 124 (21): 2880.
