NLX-219
NLX-219 is a selective agonist of the 5-HT1A with a pKi of 10.21. NLX-219 activates ERK1/2 phosphorylation, inhibits adenylyl cyclase activity, promotes β-arrestin recruitment. NLX-219 can be used for the research of neurological disease.
For research use only. We do not sell to patients.
- CAS No.: 2170404-93-8
- Formula: C21H23ClF2N2O2
- Molecular Weight:408.87
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
5-HT1A Receptor 10.21 (pKi) |
α1-adrenergic receptor 6.29 (pKi) |
ERK1 |
ERK2 |
In Vitro
NLX-219 (Compound 3) binds with high affinity to CHO-K1 cell-expressed human 5-HT1A receptors (pKi = 10.21) and α1 adrenergic receptors (pKi = 6.29), with no significant D2 dopamine receptor affinity[1].
NLX-219 fully activates ERK1/2 phosphorylation in CHO-K1 cell-expressed human 5-HT1A receptors with a pEC50 of 9.10[1].
NLX-219 fully inhibits adenylyl cyclase activity via CHO-K1 cell-expressed human 5-HT1A receptors with a pEC50 of 8.09[1].
NLX-219 fully promotes β-arrestin recruitment to U2OS cell-expressed human 5-HT1A receptors with a pEC50 of 7.98[1].
NLX-219 fully triggers calcium mobilization in CHO-K1 cell-expressed human 5-HT1A receptors with a pEC50 of 7.20[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2170404-93-8
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Molecular Weight 408.87
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Formula C21H23ClF2N2O2
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SMILES
O=C(N1CCC(CNCCOC2=CC=CC=C2)(CC1)F)C3=CC=C(C(Cl)=C3)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NLX-219 Related Classifications
HY-182389 Related Classifications
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Keywords
- NLX-219
- 2170404-93-8
- NLX219
- NLX 219
- 5-HT Receptor
- Adrenergic Receptor
- ERK
- Adenylate Cyclase
- Arrestin
- Serotonin Receptor
- 5-hydroxytryptamine Receptor
- Beta Receptor
- Extracellular signal regulated kinases
- Adenylyl cyclase
- β-arrestin
- adenylyl cyclase
- CHO-K1 cell
- 5-HT1A receptor
- α1adrenergic receptors
- ERK1/2 phosphorylation
- HepG2 cells
- D2dopamine receptor
- U2OS cell
- Inhibitor
- inhibitor
- inhibit