2. GPCR/G Protein Neuronal Signaling Stem Cell/Wnt MAPK/ERK Pathway
  3. 5-HT Receptor Adrenergic Receptor ERK Adenylate Cyclase Arrestin
  4. NLX-219

NLX-219 is a selective agonist of the 5-HT1A with a pKi of 10.21. NLX-219 activates ERK1/2 phosphorylation, inhibits adenylyl cyclase activity, promotes β-arrestin recruitment. NLX-219 can be used for the research of neurological disease.

For research use only. We do not sell to patients.

NLX-219

NLX-219 Chemical Structure

CAS No. : 2170404-93-8

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NLX-219 Related Antibodies

Top Publications Citing Use of Products

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α adrenergic receptor β adrenergic receptor

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ERK ERK1 ERK2 ERK5 ERK8

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Arrestin-2/β-Arrestin 1 Arrestin-3/β-Arrestin 2

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Description

NLX-219 is a selective agonist of the 5-HT1A with a pKi of 10.21. NLX-219 activates ERK1/2 phosphorylation, inhibits adenylyl cyclase activity, promotes β-arrestin recruitment. NLX-219 can be used for the research of neurological disease[1].

IC50 & Target[1]

5-HT1A Receptor

10.21 (pKi)

α1-adrenergic receptor

6.29 (pKi)

ERK1

 

ERK2

 

In Vitro

NLX-219 (Compound 3) binds with high affinity to CHO-K1 cell-expressed human 5-HT1A receptors (pKi = 10.21) and α1 adrenergic receptors (pKi = 6.29), with no significant D2 dopamine receptor affinity[1].
NLX-219 fully activates ERK1/2 phosphorylation in CHO-K1 cell-expressed human 5-HT1A receptors with a pEC50 of 9.10[1].
NLX-219 fully inhibits adenylyl cyclase activity via CHO-K1 cell-expressed human 5-HT1A receptors with a pEC50 of 8.09[1].
NLX-219 fully promotes β-arrestin recruitment to U2OS cell-expressed human 5-HT1A receptors with a pEC50 of 7.98[1].
NLX-219 fully triggers calcium mobilization in CHO-K1 cell-expressed human 5-HT1A receptors with a pEC50 of 7.20[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NLX-219 Related Antibodies
Molecular Weight

408.87

Formula

C21H23ClF2N2O2
CAS No.
SMILES

O=C(N1CCC(CNCCOC2=CC=CC=C2)(CC1)F)C3=CC=C(C(Cl)=C3)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NLX-219 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NLX-2192170404-93-8NLX219NLX 2195-HT ReceptorAdrenergic ReceptorERKAdenylate CyclaseArrestinSerotonin Receptor5-hydroxytryptamine ReceptorBeta ReceptorExtracellular signal regulated kinasesAdenylyl cyclaseβ-arrestinadenylyl cyclaseCHO-K1 cell5-HT1A receptorα1adrenergic receptorsERK1/2 phosphorylationHepG2 cellsD2dopamine receptorU2OS cellInhibitorinhibitorinhibit

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