L-742001 hydrochloride

Cat. No.: HY-118368 Purity: 99.9%: Data Sheet
COA

SDS
Handling Instructions
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L-742001 hydrochloride is an influenza virus PA endonuclease inhibitor, with an EC₉₀ of 4.3 μM for vRNP activity in HEK293T cells.

For research use only. We do not sell to patients.

L-742001 hydrochloride Chemical Structure

CAS No. : 174605-64-2

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Purity & Documentation
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Description

L-742001 hydrochloride is an influenza virus PA endonuclease inhibitor, with an EC₉₀ of 4.3 μM for vRNP activity in HEK293T cells^[1].

Molecular Weight

450.35

Formula

C₂₃H₂₅Cl₂NO₄

CAS No.

174605-64-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(/C(O)=C/C(C1(CCN(CC1)CC2=CC=CC=C2)CC3=CC=C(C=C3)Cl)=O)O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 20 mg/mL (44.41 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2205 mL	11.1025 mL	22.2050 mL
5 mM	0.4441 mL	2.2205 mL	4.4410 mL
10 mM	0.2220 mL	1.1102 mL	2.2205 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.9%

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Data Sheet (270 KB) SDS (536 KB)

COA (252 KB)

Handling Instructions (2659 KB)

References

[1]. Annelies Stevaert, et al. Mutational analysis of the binding pockets of the diketo acid inhibitor L-742,001 in the influenza virus PA endonuclease. J Virol. 2013 Oct;87(19):10524-38. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2205 mL	11.1025 mL	22.2050 mL	55.5124 mL
	5 mM	0.4441 mL	2.2205 mL	4.4410 mL	11.1025 mL
	10 mM	0.2220 mL	1.1102 mL	2.2205 mL	5.5512 mL
	15 mM	0.1480 mL	0.7402 mL	1.4803 mL	3.7008 mL
	20 mM	0.1110 mL	0.5551 mL	1.1102 mL	2.7756 mL
	25 mM	0.0888 mL	0.4441 mL	0.8882 mL	2.2205 mL
	30 mM	0.0740 mL	0.3701 mL	0.7402 mL	1.8504 mL
	40 mM	0.0555 mL	0.2776 mL	0.5551 mL	1.3878 mL