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Cat. No.: HY-138934

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Bepristat 1a

Bepristat 1a is a reversible, selective protein disulfide isomerase (PDI) inhibitor with an IC₅₀ of 0.7 μM. Bepristat 1a inhibits platelet aggregation in laser-injured mouse arterioles. Bepristat 1a is applicable for research related to thrombosis.

For research use only. We do not sell to patients.

CAS No.: 1642375-66-3
Formula: C₂₄H₃₁ClN₂O₃
Molecular Weight:430.97

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Bepristat 1a Chemical Structure

CAS No.: 1642375-66-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

In Vitro

Bepristat 1a is a reversible PDI inhibitor that binds to the b' substrate-binding pocket of this enzyme and modulates the catalytic activity of its a and a' domains^[1].
Bepristat 1a inhibits full-length recombinant PDI-mediated insulin reduction in the insulin turbidimetric assay, with an IC₅₀ of approximately 0.7 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Bepristat 1a (15 mg/kg; i.v.; single dose) reduces platelet accumulation at laser-induced vascular injury sites in male C57BL/6J mice by 79.7%^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (8-week-old male)^[2]
Dosage:

15 mg/kg
Administration:

i.v.; single dose
Result:

Reduced platelet accumulation at sites of vascular injury by 79.7% (P = 0.02).

Chemical Information

CAS No. 1642375-66-3
Molecular Weight 430.97
Formula C₂₄H₃₁ClN₂O₃
SMILES

O=C(N(C)CC)C1(CCOC=2C=CC=CC2)CCN(CC3=CC=C(O)C(Cl)=C3)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Keovilay J. The role of isoquercetin, zafirlukast and its novel analogues for thiol isomerase inhibition in relation to thrombosis, cancer and other complications[D]. University of Reading, 2025.

[2]. Bekendam RH, et al. A substrate-driven allosteric switch that enhances PDI catalytic activity. Nature communications. 2016 Aug 30;7:12579. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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