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Art. -Nr.: HY-138934

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Bepristat 1a

Bepristat 1a is a reversible, selective protein disulfide isomerase (PDI) inhibitor with an IC₅₀ of 0.7 μM. Bepristat 1a inhibits platelet aggregation in laser-injured mouse arterioles. Bepristat 1a is applicable for research related to thrombosis.

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CAS. Nr.: 1642375-66-3
Formel: C₂₄H₃₁ClN₂O₃
Molecular Weight:430.97

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Bepristat 1a Chemical Structure

CAS. Nr.: 1642375-66-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Bepristat 1a is a reversible PDI inhibitor that binds to the b' substrate-binding pocket of this enzyme and modulates the catalytic activity of its a and a' domains^[1].
Bepristat 1a inhibits full-length recombinant PDI-mediated insulin reduction in the insulin turbidimetric assay, with an IC₅₀ of approximately 0.7 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Local Vascular Regulation

Bepristat 1a (15 mg/kg; i.v.; single dose) reduces platelet accumulation at laser-induced vascular injury sites in male C57BL/6J mice by 79.7%^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (8-week-old male)^[2]
Dosage:

15 mg/kg
Administration:

i.v.; single dose
Result:

Reduced platelet accumulation at sites of vascular injury by 79.7% (P = 0.02).

Chemical Information

CAS. Nr. 1642375-66-3
Molecular Weight 430.97
Formel C₂₄H₃₁ClN₂O₃
SMILES

O=C(N(C)CC)C1(CCOC=2C=CC=CC2)CCN(CC3=CC=C(O)C(Cl)=C3)CC1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Keovilay J. The role of isoquercetin, zafirlukast and its novel analogues for thiol isomerase inhibition in relation to thrombosis, cancer and other complications[D]. University of Reading, 2025.

[2]. Bekendam RH, et al. A substrate-driven allosteric switch that enhances PDI catalytic activity. Nature communications. 2016 Aug 30;7:12579. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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