1642375-66-3
1642375-66-3
Chemical Structure
Bepristat 1a
- CAS No.: 1642375-66-3
- Formula:C24H31ClN2O3
- Molecular Weight:430.97
IUPAC Name: 1-(3-chloro-4-hydroxybenzyl)-N-ethyl-N-methyl-4-(2-phenoxyethyl)piperidine-4-carboxamide
InChIKey: AYJKPBTXOIHUFT-UHFFFAOYSA-N
SMILES: O=C(N(C)CC)C1(CCOC=2C=CC=CC2)CCN(CC3=CC=C(O)C(Cl)=C3)CC1
Biological Activity: Bepristat 1a is a reversible, selective protein disulfide isomerase (PDI) inhibitor with an IC50 of 0.7 μM. Bepristat 1a inhibits platelet aggregation in laser-injured mouse arterioles. Bepristat 1a is applicable for research related to thrombosis[1][2].
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Bepristat 1a | Bepristat 1a is a reversible, selective protein disulfide isomerase (PDI) inhibitor with an IC50 of 0.7 μM. Bepristat 1a inhibits platelet aggregation in laser-injured mouse arterioles. Bepristat 1a is applicable for research related to thrombosis. | |||||||||||||||||||||
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References
- [1]. Keovilay J. The role of isoquercetin, zafirlukast and its novel analogues for thiol isomerase inhibition in relation to thrombosis, cancer and other complications[D]. University of Reading, 2025.
- [2]. Bekendam RH, et al. A substrate-driven allosteric switch that enhances PDI catalytic activity. Nature communications. 2016 Aug 30;7:12579. [Content Brief]
Keywords
