2. Membrane Transporter/Ion Channel
  3. Na+/K+ ATPase
  4. Chlorpropamide

クロルプロパミド  (Synonyms: Chlorpropamide)

製品番号: HY-B1429 純度: 99.79%
COA 取扱説明書 Technical Support

Chlorpropamide is an oral hypoglycemic agent that can influence acetaldehyde metabolism in mice and has a potentiating effect on antidiuretic hormone.

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Chlorpropamide

クロルプロパミド 構造式

CAS 番号 : 94-20-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 33 在庫あり
Solution
10 mM * 1 mL in DMSO USD 33 在庫あり
Solid
500 mg $30 在庫あり
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Based on 4 publication(s) in Google Scholar

Other Forms of Chlorpropamide:

クロルプロパミド 関連抗体

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製品説明

Chlorpropamide is an oral hypoglycemic agent that can influence acetaldehyde metabolism in mice and has a potentiating effect on antidiuretic hormone[1][2][3][4].

Cellular Effect
Cell Line Type Value Description References
Sf21 IC50
>1000 μM
Compound: Chlorpropamide
Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
[PMID: 21965623]
Sf21 IC50
>1000 μM
Compound: Chlorpropamide
Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
[PMID: 21965623]
体外実験

Chlorpropamide (0.1 mM, 90 min) increases the cAMP accumulation in the thick ascending limb of the loop of Henle (MAL)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

クロルプロパミド 関連抗体
体内実験

Chlorpropamide (2 mg/kg; subcutaneously; once daily; seven days) enhances the antidiuretic effect of vasopressin (VP) by increasing the tension in the medullary and papillary regions of rats[1].
Chlorpropamide (20-200 mg/kg; subcutaneously; once daily; three months) does not significantly affect the structure or function of pancreatic islets in diabetic rats[2].
Chlorpropamide (250 mg/kg; orally; single dose) lowers blood sugar levels in rats[3].
Chlorpropamide (2.5-250 mg/kg; orally; single dose) can affect the metabolism of acetaldehyde in mice, and this is related to the mouse strain[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Hypothalamic diabetes insipidus rat[1]
Dosage: 2 mg/kg; daily; 7 days
Administration: Subcutaneous injection (s.c.)
Result: Did not change water intake, urine flow, urine osmolality, urinary excretion of Na+, K+, creatinine, or total solute excretion, but increased the osmotic gradient between urine and papillary tissue.
Animal Model: 95% partial pancreatectomy diabetic rats[2]
Dosage: 20, 50, 200 mg/kg; daily; 3 months
Administration: Subcutaneous injection (s.c.)
Result: Had little effect on fasting blood glucose and pancreatic islet structure, and did not cause changes in the size of the pancreatic endocrine cell area.
Animal Model: Sprague-Dawley rat[3]
Dosage: 250 mg/kg; single dose
Administration: Oral
Result: Could significantly lower blood sugar levels.
Animal Model: C57BL and DBA mice[4]
Dosage: 2.5, 8, 25, 80, 250 mg/kg; 100 mg/kg; single dose
Administration: Oral
Result: Increased blood acetaldehyde concentrations without significantly altering high or low Km aldehyde dehydrogenase (ALDH) activity in liver cytochromes.
臨床実験
分子量

276.74

分子式

C10H13ClN2O3S
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C(Cl)C=C1)(NC(NCCC)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : ≥ 100 mg/mL (361.35 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6135 mL 18.0675 mL 36.1350 mL
5 mM 0.7227 mL 3.6135 mL 7.2270 mL
10 mM 0.3614 mL 1.8068 mL 3.6135 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (9.03 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (9.03 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 99.79%

COA (246 KB) HNMR (264 KB) LCMS (100 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6135 mL 18.0675 mL 36.1350 mL 90.3375 mL
5 mM 0.7227 mL 3.6135 mL 7.2270 mL 18.0675 mL
10 mM 0.3614 mL 1.8068 mL 3.6135 mL 9.0338 mL
15 mM 0.2409 mL 1.2045 mL 2.4090 mL 6.0225 mL
20 mM 0.1807 mL 0.9034 mL 1.8068 mL 4.5169 mL
25 mM 0.1445 mL 0.7227 mL 1.4454 mL 3.6135 mL
30 mM 0.1205 mL 0.6023 mL 1.2045 mL 3.0113 mL
40 mM 0.0903 mL 0.4517 mL 0.9034 mL 2.2584 mL
50 mM 0.0723 mL 0.3614 mL 0.7227 mL 1.8068 mL
60 mM 0.0602 mL 0.3011 mL 0.6023 mL 1.5056 mL
80 mM 0.0452 mL 0.2258 mL 0.4517 mL 1.1292 mL
100 mM 0.0361 mL 0.1807 mL 0.3614 mL 0.9034 mL
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Chlorpropamide Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chlorpropamide94-20-2Na+/K+ ATPaseSodium potassium pumpDiabetesoralacetaldehyde metabolismantidiuretic hormoneInhibitorinhibitorinhibit

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