Crolibulin (Synonyms: EPC2407)

Name: Crolibulin
Brand: MedChemExpress
SKU: HY-13603
Rating: 4.5 (1 reviews)

Art. -Nr.: HY-13603 Reinheit: 98.96%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Crolibulin (EPC2407) is a tubulin polymerization inhibitor, with potent apoptosis induction and cell growth inhibition. Crolibulin has anti-tumor activity. Crolibulin also has cardiovascular toxicity and neurotoxicity.

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Crolibulin Chemische Struktur

CAS. Nr. : 1000852-17-4

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Kostenlose Probe (0.1 - 0.2 mg)	Jetzt bewerben
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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
100 mg	Auf Lager	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE Crolibulin

•Biochem Biophys Res Commun. 2019 Apr 2;511(2):381-386. [Abstract]

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität
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Beschreibung

IC₅₀ & Target

Tubulin polymerization^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.39 μM Compound: Crolibulin	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 29407949]
HT-29	IC₅₀	0.55 μM Compound: Crolibulin	Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay	[PMID: 29407949]
MKN-45	IC₅₀	0.17 μM Compound: Crolibulin	Antiproliferative activity against human MKN45 cells after 72 hrs by MTT assay Antiproliferative activity against human MKN45 cells after 72 hrs by MTT assay	[PMID: 29407949]
NCI-H460	IC₅₀	0.03 μM Compound: Crolibulin	Antiproliferative activity against human H460 cells after 72 hrs by MTT assay Antiproliferative activity against human H460 cells after 72 hrs by MTT assay	[PMID: 29407949]

In Vitro

Crolibulin shows significant cytotoxic activity against HT-29 cells, with an IC₅₀ of 0.52 μM^[2].
Crolibulin is active against various experimental tumors and exhibit potent inhibition of mitosis at the G2/M stage^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Klinische Studie

Molekulargewicht

417.26

Formel

C₁₈H₁₇BrN₄O₃

CAS. Nr.

1000852-17-4

Appearance

Solid

Color

Light yellow to yellow

SMILES

N#CC1=C(N)OC2=C(N)C(N)=CC=C2[C@H]1C3=CC(OC)=C(OC)C(Br)=C3

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 125 mg/mL (299.57 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3966 mL	11.9829 mL	23.9659 mL
5 mM	0.4793 mL	2.3966 mL	4.7932 mL
10 mM	0.2397 mL	1.1983 mL	2.3966 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 98.96%

Select Batch:

Data Sheet (278 KB) SDS (393 KB)

COA (257 KB) HNMR (143 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Kalmuk J, et al. Multimodal imaging guided preclinical trials of vascular targeting in prostate cancer. Oncotarget. 2015 Sep 15;6(27):24376-92. [Content Brief]

[2]. Zhai X, et al. Discovery and Optimization of Novel 5-Indolyl-7-arylimidazo[1,2-a]pyridine-8-carbonitrile Derivatives as Potent Antitubulin Agents Targeting Colchicine-binding Site. Sci Rep. 2017 Feb 27;7:43398. [Content Brief]

[3]. S. P. Anthony, et al. EPC2407, a new beta-tubulin vascular disrupting agent with potent apoptosis and cell growth inhibition. Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007) 14043-14043.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3966 mL	11.9829 mL	23.9659 mL	59.9147 mL
	5 mM	0.4793 mL	2.3966 mL	4.7932 mL	11.9829 mL
	10 mM	0.2397 mL	1.1983 mL	2.3966 mL	5.9915 mL
	15 mM	0.1598 mL	0.7989 mL	1.5977 mL	3.9943 mL
	20 mM	0.1198 mL	0.5991 mL	1.1983 mL	2.9957 mL
	25 mM	0.0959 mL	0.4793 mL	0.9586 mL	2.3966 mL
	30 mM	0.0799 mL	0.3994 mL	0.7989 mL	1.9972 mL
	40 mM	0.0599 mL	0.2996 mL	0.5991 mL	1.4979 mL
	50 mM	0.0479 mL	0.2397 mL	0.4793 mL	1.1983 mL
	60 mM	0.0399 mL	0.1997 mL	0.3994 mL	0.9986 mL
	80 mM	0.0300 mL	0.1498 mL	0.2996 mL	0.7489 mL
	100 mM	0.0240 mL	0.1198 mL	0.2397 mL	0.5991 mL

Crolibulin Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Crolibulin (Synonyms: EPC2407)

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Crolibulin Related Antibodies

1 Publications Citing Use of MCE Crolibulin

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität

Reinheit & Dokumentation

Verweise

Kundenbewertung

Crolibulin Related Antibodies

Molaritätsrechner

Verdünnungsrechner

Complete Stock Solution Preparation Table

Crolibulin Related Classifications

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SAFETY DATA SHEET (SDS)

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