1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. Dipraglurant

Dipraglurant (Synonyms: ADX48621)

Cat. No.: HY-14859 Purity: 99.99%
Handling Instructions

Dipraglurant (ADX 48621) is a mGluR5 antagonists with IC50 of 0.021 μM.

For research use only. We do not sell to patients.

Dipraglurant Chemical Structure

Dipraglurant Chemical Structure

CAS No. : 872363-17-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 490 In-stock
Estimated Time of Arrival: December 31
1 mg USD 168 In-stock
Estimated Time of Arrival: December 31
5 mg USD 383 In-stock
Estimated Time of Arrival: December 31
10 mg USD 528 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1980 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

Dipraglurant (ADX 48621) is a mGluR5 antagonists with IC50 of 0.021 μM. IC50 Value: 0.021 μM [1] Target: mGluR Dipraglurant (ADX-48621) from Addex Therapeutics showed in vivo activity in different anxiety models in rat50 and is currently in phase II for the treatment of dyskinesia in Parkinson's disease.

Clinical Trial
Molecular Weight

265.29

Formula

C₁₆H₁₂FN₃

CAS No.

872363-17-2

SMILES

FC1=CN2C(C=C1)=NC(CCC#CC3=NC=CC=C3)=C2

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 40 mg/mL (150.78 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7695 mL 18.8473 mL 37.6946 mL
5 mM 0.7539 mL 3.7695 mL 7.5389 mL
10 mM 0.3769 mL 1.8847 mL 3.7695 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.99%

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Dipraglurant
Cat. No.:
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