1. GPCR/G Protein
  2. mGluR

Dipraglurant (Synonyms: ADX48621)

Cat. No.: HY-14859 Purity: 99.50%
Handling Instructions

Dipraglurant (ADX 48621) is a mGluR5 antagonists with IC50 of 0.021 μM.

For research use only. We do not sell to patients.

Dipraglurant Chemical Structure

Dipraglurant Chemical Structure

CAS No. : 872363-17-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 490 In-stock
Estimated Time of Arrival: December 31
1 mg USD 168 In-stock
Estimated Time of Arrival: December 31
5 mg USD 383 In-stock
Estimated Time of Arrival: December 31
10 mg USD 528 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1980 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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  • Technical Information

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  • References

Description

Dipraglurant (ADX 48621) is a mGluR5 antagonists with IC50 of 0.021 μM. IC50 Value: 0.021 μM [1] Target: mGluR Dipraglurant (ADX-48621) from Addex Therapeutics showed in vivo activity in different anxiety models in rat50 and is currently in phase II for the treatment of dyskinesia in Parkinson's disease.

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 40 mg/mL (150.78 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7695 mL 18.8473 mL 37.6946 mL
5 mM 0.7539 mL 3.7695 mL 7.5389 mL
10 mM 0.3769 mL 1.8847 mL 3.7695 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

265.29

Formula

C₁₆H₁₂FN₃

CAS No.

872363-17-2

SMILES

FC1=CN2C(C=C1)=NC(CCC#CC3=NC=CC=C3)=C2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Dipraglurant
Cat. No.:
HY-14859
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Dipraglurant

Cat. No.: HY-14859