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  4. Dulaglutide

Dulaglutide  (Synonyms: LY2189265)

製品番号: HY-P0120 純度: 96%
COA 取扱説明書 Technical Support

Dulaglutide (LY2189265) is a glucagon-like peptide-1 (GLP-1) receptor agonist. Dulaglutide can be uesd for the research of type 2 diabetes (T2D) .

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CAS 番号 : 923950-08-7

容量 価格（税別） 在庫状況 数量
1 mg $270 在庫あり
5 mg $800 在庫あり
10 mg $1360 在庫あり
25 mg $2500 在庫あり
50 mg $4000 在庫あり
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Based on 1 publication(s) in Google Scholar

Other Forms of Dulaglutide:

Dulaglutide 関連抗体

Top Publications Citing Use of Products
Cell Imaging/Staining
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    Dulaglutide purchased from MedChemExpress. Usage Cited in: Endocrinol Metab. 2022 Feb;37(1):74-83.  [Abstract]

    Dulaglutide (Dula) inhibits palmitic acid (PA)-induced lipid accumulation in HepG2 cells. Cells were pre-treated with 400 μM PA for 24 hours, followed by treatment with or without 100 nM Dula for 24 hours. Lipid accumulation were evaluated using Oil red O staining.

    Dulaglutide purchased from MedChemExpress. Usage Cited in: Endocrinol Metab. 2022 Feb;37(1):74-83.  [Abstract]

    Dula glycopeptide (Dula) reduced lipogenesis and triglyceride (TG) synthesis in palmitic acid (PA)-treated HepG2 cells and increased TG secretion. HepG2 cells were pretreated with 400 μM PA for 24 hours, followed by treatment with or without 100 nM Dula for 24 hours. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to analyze the mRNA expression levels of genes encoding sterol regulatory binding protein 1 (SREBP-1), acetyl-CoA carboxylase (ACC), and fatty acid synthase (FAS).

    Dulaglutide purchased from MedChemExpress. Usage Cited in: Endocrinol Metab. 2022 Feb;37(1):74-83.  [Abstract]

    Cells were pre-treated with 400 μM PA for 24 hours, followed by treatment with or without 100 nM Dulaglutide and 100 nM exendin (9–39), a GLP-1R antagonist, for 24 hours. FAM3A, GLP-1R, sirtuin 1 (SIRT1), phospho-adenosine monophosphate-activated protein kinase (p-AMPK), phospho-acetyl-CoA carboxylase (p-ACC), and peroxisome proliferator-activated receptor alpha (PPARα) levels were analyzed using Western blotting.

    Dulaglutide purchased from MedChemExpress. Usage Cited in: Endocrinol Metab. 2022 Feb;37(1):74-83.  [Abstract]

    Dulaglutide (Dula) inhibits lipid deposition and increases fatty acid oxidation via family with sequence similarity 3 member A (FAM3A). HepG2 cells transfected with 10 nM FAM3A small interfering RNA (siRNA) or control (Con) siRNA for 24 hours were pretreated with 400 μM palmitic acid (PA) for 24 hours, followed by treatment with or without 100 nM Dula for 24 hours. Lipid deposition was evaluated using triglyceride (TG) content assay.

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    製品説明

    Dulaglutide (LY2189265) is a glucagon-like peptide-1 (GLP-1) receptor agonist. Dulaglutide can be uesd for the research of type 2 diabetes (T2D) [1][2].

    IC50 & Target

    GLP-1 receptor[1]
    体外実験

    Dulaglutide (50 nM and 100 nM; 24 h) ameliorates ox-LDL-induced oxidative stress and suppresses ox-LDL-induced mitochondrial dysfunction in human aortic endothelial cells (HAECs)[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Dulaglutide 関連抗体

    Cell Viability Assay[1]

    Cell Line: Human aortic endothelial cells (HAECs)
    Concentration: 50 nM, 100 nM
    Incubation Time: 24 hous
    Result: Suppressed ox-LDL-induced reduction of cell viability and release of lactate dehydrogenase (LDH).
    体内実験

    Dulaglutide (0, 0.05, 0.5, 1.5, or 5 mg/kg; s.c.; twice week, for 93 weeks) increases the incidence of thyroid C-cell hyperplasia and neoplasia in the rat carcinogenicity study[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Rats and Transgenic mice[1]
    Dosage: 0, 0.05, 0.5, 1.5, or 5 mg/kg; 0, 0.3, 1, or 3 mg/kg
    Administration: SC, twice week, for 93 weeks; SC, twice week, for 26 weeks
    Result: Statistically increased diffuse C-cell hyperplasia and adenomas at ＞0.5 mg/kg.
    Decreased Systemic exposures over time in mice.
    臨床実験
    分子量

    62561 (Glycosylation, Dominant form)

    CAS 番号
    Appearance

    Liquid

    Color

    Colorless to light yellow

    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    Store at 4°C, do not freeze
    純度とドキュメンテーション

    純度: 96%

    COA (232 KB)

    取扱説明書 (2659 KB)
    参考文献
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    Dulaglutide Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Dulaglutide923950-08-7LY2189265LY 2189265LY-2189265GCGRGlucagon Receptorglucagon-like peptide-1 (GLP-1)receptor type 2 diabetes (T2D)Inhibitorinhibitorinhibit

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    製品番号:
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