2. GPCR/G Protein
  3. LPL Receptor
  4. FTY720 (S)-Phosphate

FTY720 (S)-Phosphate  (Synonyms: (S)-FTY720P; (S)-FTY720 phosphate)

製品番号: HY-15382 純度: 99.73% ee.: 99.76%
COA 取扱説明書

Molarity Calculator

FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

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FTY720 (S)-Phosphate 構造式

FTY720 (S)-Phosphate 構造式

CAS 番号 : 402616-26-6

容量 価格（税別） 在庫状況 数量
5 mg USD 520 在庫あり
10 mg USD 830 在庫あり
25 mg USD 1680 在庫あり
50 mg USD 2690 在庫あり
100 mg USD 4300 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

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Based on 1 publication(s) in Google Scholar

Other Forms of FTY720 (S)-Phosphate:

FTY720 (S)-Phosphate 関連抗体

Top Publications Citing Use of Products

LPL Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

  • 生物活性

  • プロトコル

  • 純度とドキュメンテーション

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製品説明

FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

IC50 & Target

S1PR1[1]
体外実験

FTY720 (S)-Phosphate is an agonist of S1PR1. FTY720 (S)-Phosphate (Tys, 1 µM) maintains S1PR1 protein expression, enhances the human pulmonary artery endothelial cells barrier via S1PR1, but shows no effect on inducing ubiquitination of S1PR1. FTY720 (S)-Phosphate (0.01-50 µM) also reduces β-arrestin recruitment to S1PR1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FTY720 (S)-Phosphate 関連抗体
体内実験

FTY720 (S)-Phosphate (0.5 mg/kg, i.p.) preserves S1PR1 expression in mouse lungs, is protective in bleomycin-induced acute lung injury (ALI) and attenuates lung tissue leukocyte infiltration in bleomycin-injured mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

387.45

分子式

C19H34NO5P
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

OC[C@](CCC1=CC=C(CCCCCCCC)C=C1)(N)COP(O)(O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years

*The compound is unstable in solutions, freshly prepared is recommended.
溶剤 & 溶解度
体外: 

DMSO : 1 mg/mL (2.58 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5810 mL 12.9049 mL 25.8098 mL
5 mM --- --- ---
10 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

体内:

The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

  • Protocol 1

    FTY720 (S)-Phosphate is dissolved in sterile water[2].

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.73% ee.: 99.76%

COA (243 KB) HNMR (204 KB) RP-HPLC (260 KB) NP-HPLC (455 KB) LCMS (95 KB)

取扱説明書 (2659 KB)
参考文献
動物実験
[1]

Mice[1] Male C57BL/6 (20-25 g) mice 8-10 weeks old receive a single intratracheal dose of bleomycin at 0.6 U/kg (or sterile saline) on Day 0 followed immediately by intraperitoneal injection of FTY720 (S)-Phosphate (0.5 mg/kg), FTY720 (0.5 mg/kg), or saline. Additional doses of FTY720 (S)-Phosphate or FTY720 are injected on Days 3 and 6. Bronchoalveolar lavage (BAL) fluid and lungs are then collected on Day 7. BAL fluid is used to detect BAL protein levels, WBC count, and WBC differential count. Lungs are perfused with saline to remove blood for Western blot, tissue albumin, and histopathology evaluation. Peripheral blood is obtained on Day 7 for examination of total cell counts and lymphocytes. Experiments are repeated 3 times. 6-10 mice are used per experimental group[1].

MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5810 mL 12.9049 mL 25.8098 mL 64.5245 mL
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FTY720 (S)-Phosphate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FTY720 (S)-Phosphate402616-26-6(S)-FTY720P(S)-FTY720LPL ReceptorLysophospholipid ReceptorInhibitorinhibitorinhibit

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製品名:
FTY720 (S)-Phosphate
製品番号:
HY-15382
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