1. GPCR/G Protein
  2. LPL Receptor
  3. FTY720 (S)-Phosphate

FTY720 (S)-Phosphate (Synonyms: (S)-FTY720P; (S)-FTY720 phosphate)

製品番号: HY-15382 純度: >98.0%
取扱説明書

FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

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FTY720 (S)-Phosphate 構造式

FTY720 (S)-Phosphate 構造式

CAS 番号 : 402616-26-6

容量 価格(税別) 在庫状況 数量
1 mg USD 220 在庫あり
Estimated Time of Arrival: December 31
5 mg USD 790 在庫あり
Estimated Time of Arrival: December 31
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50 mg   お問い合わせ  

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製品説明

FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

IC50 & Target

S1PR1[1]

体外実験

FTY720 (S)-Phosphate is an agonist of S1PR1. FTY720 (S)-Phosphate (Tys, 1 µM) maintains S1PR1 protein expression, enhances the human pulmonary artery endothelial cells barrier via S1PR1, but shows no effect on inducing ubiquitination of S1PR1. FTY720 (S)-Phosphate (0.01-50 µM) also reduces β-arrestin recruitment to S1PR1[1].

体内実験

FTY720 (S)-Phosphate (0.5 mg/kg, i.p.) preserves S1PR1 expression in mouse lungs, is protective in bleomycin-induced acute lung injury (ALI) and attenuates lung tissue leukocyte infiltration in bleomycin-injured mice[1].

分子量

387.45

分子式

C₁₉H₃₄NO₅P

CAS 番号

402616-26-6

SMILES

OC[[email protected]](CCC1=CC=C(CCCCCCCC)C=C1)(N)COP(O)(O)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

H2O : < 0.1 mg/mL (insoluble)

体内:
  • 1.

    FTY720 (S)-Phosphate is dissolved in sterile water[2].

参考文献
動物実験
[1]

Mice[1] Male C57BL/6 (20-25 g) mice 8-10 weeks old receive a single intratracheal dose of bleomycin at 0.6 U/kg (or sterile saline) on Day 0 followed immediately by intraperitoneal injection of FTY720 (S)-Phosphate (0.5 mg/kg), FTY720 (0.5 mg/kg), or saline. Additional doses of FTY720 (S)-Phosphate or FTY720 are injected on Days 3 and 6. Bronchoalveolar lavage (BAL) fluid and lungs are then collected on Day 7. BAL fluid is used to detect BAL protein levels, WBC count, and WBC differential count. Lungs are perfused with saline to remove blood for Western blot, tissue albumin, and histopathology evaluation. Peripheral blood is obtained on Day 7 for examination of total cell counts and lymphocytes. Experiments are repeated 3 times. 6-10 mice are used per experimental group[1].

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参考文献

純度: >98.0%

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Keywords:

FTY720 (S)-Phosphate(S)-FTY720P(S)-FTY720LPL ReceptorLysophospholipid ReceptorInhibitorinhibitorinhibit

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製品名:
FTY720 (S)-Phosphate
製品番号:
HY-15382
数量:
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