2. Immunology/Inflammation
  3. Galectin
  4. GB1107

GB1107 is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with a Kd of 37 nM for human Galectin-3. GB1107 reduces human and mouse lung adenocarcinoma growth and blocks metastasis in the syngeneic model.

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CAS 番号 : 1978336-61-6

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 180 在庫あり
Solution
10 mM * 1 mL in DMSO USD 180 在庫あり
Solid
5 mg $157 在庫あり
10 mg $266 在庫あり
25 mg $564 在庫あり
50 mg $962 在庫あり
100 mg $1665 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 19 publication(s) in Google Scholar

GB1107 関連抗体

Top Publications Citing Use of Products

    GB1107 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 7;16(1):7287.  [Abstract]

    Eight-week-old female C57BL/6 J mice were fed with a chow diet. Full-thickness skin wounds were created and i.c. injected with Gal-3 inhibitor (GB1107, 133 μM, 100 µL/mouse) or solvent control (Veh). Picrosirius red staining in healed wound.

    GB1107 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 7;16(1):7287.  [Abstract]

    Eight-week-old female C57BL/6 J mice were fed with a chow diet. Full-thickness skin wounds were created and i.c. injected with Gal-3 inhibitor (GB1107, 133 μM, 100 µL/mouse) or solvent control (Veh). CD31 staining in healed wound.

    GB1107 purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2024 May 21;5(5):101505.  [Abstract]

    mIF imaging depicting the MCTC structure and distribution of CD8+ T cells (left), along with statistical analysis of the MCTC count (right), in C57 mice with subcutaneously implanted Hepa1-6NC and Hepa1-6M2Bphi tumors both with and without GB1107 (10 mg/kg, p.o.) treatment.

    GB1107 purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2024 May 21;5(5):101505.  [Abstract]

    Overview of the tumor mass (left) and tumor growth curves (right) in the subcutaneously implanted tumors of the above groups. GB1107 (10 mg/kg, p.o.) reduced tumor burden and metastasis.

    GB1107 purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2024 May 21;5(5):101505.  [Abstract]

    Supplemented with 1 μM GB1107, a migration assay was performed to quantify the number of macrophages that migrated when cocultured with tumor cells treated as described above at 24 h.

    Galectin アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Galectin-1 Galectin-3 Galectin-4 Galectin-8

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    GB1107 is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with a Kd of 37 nM for human Galectin-3. GB1107 reduces human and mouse lung adenocarcinoma growth and blocks metastasis in the syngeneic model[1].

    IC50 & Target

    Galectin-3

     

    体外実験

    Treatment with GB1107 (0-1 μM) increases tumor M1 macrophage polarization and CD8+ T cell infiltration in LLC cells by flow cytometric analysis. GB1107 potentiates the effects of a PD-L1 immune checkpoint inhibitor to increase expression of cytotoxic (IFN-γ, granzyme B, perforin-1, Fas ligand) and apoptotic (cleaved caspase-3) effector molecules[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    GB1107 関連抗体
    体内実験

    GB1107 (10 mg/kg, p.o., once daily from day 18-30 post implantation) treatment results in significantly reduced tumor growth and final tumor weights[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: CD-1 nude female mice received 3x106 human lung adenocarcinoma cells (A549)[1].
    Dosage: 10 mg/kg
    Administration: Oral once daily from day 18-30 post implantation.
    Result: Resulted in significantly reduced tumor growth and final tumor weights.
    分子量

    522.32

    分子式

    C20H16Cl2F3N3O4S
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O[C@H]([C@@H](N1N=NC(C2=CC(F)=C(F)C(F)=C2)=C1)[C@H]([C@@H](CO)O3)O)[C@H]3SC4=CC=C(Cl)C(Cl)=C4
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    -20°C, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
    溶剤 & 溶解度
    体外: 

    DMSO : 50 mg/mL (95.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9145 mL 9.5727 mL 19.1453 mL
    5 mM 0.3829 mL 1.9145 mL 3.8291 mL
    10 mM 0.1915 mL 0.9573 mL 1.9145 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (stored under nitrogen). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

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    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (4.79 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (4.79 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
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    +
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    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 2 years; -20°C, 1 year (stored under nitrogen)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.92%

    COA (258 KB) HNMR (263 KB) LCMS (93 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (stored under nitrogen). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.9145 mL 9.5727 mL 19.1454 mL 47.8634 mL
    5 mM 0.3829 mL 1.9145 mL 3.8291 mL 9.5727 mL
    10 mM 0.1915 mL 0.9573 mL 1.9145 mL 4.7863 mL
    15 mM 0.1276 mL 0.6382 mL 1.2764 mL 3.1909 mL
    20 mM 0.0957 mL 0.4786 mL 0.9573 mL 2.3932 mL
    25 mM 0.0766 mL 0.3829 mL 0.7658 mL 1.9145 mL
    30 mM 0.0638 mL 0.3191 mL 0.6382 mL 1.5954 mL
    40 mM 0.0479 mL 0.2393 mL 0.4786 mL 1.1966 mL
    50 mM 0.0383 mL 0.1915 mL 0.3829 mL 0.9573 mL
    60 mM 0.0319 mL 0.1595 mL 0.3191 mL 0.7977 mL
    80 mM 0.0239 mL 0.1197 mL 0.2393 mL 0.5983 mL
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    GB1107 Related Classifications

    • Molarity Calculator

    • Dilution Calculator

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    GB11071978336-61-6GB 1107GB-1107GalectinInhibitorinhibitorinhibit

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    製品名:
    GB1107
    製品番号:
    HY-114409
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