2. Vitamin D Related/Nuclear Receptor
  3. Progesterone Receptor
  4. Hydroxyprogesterone caproate

Hydroxyprogesterone caproate  (Synonyms: 17α-Hydroxyprogesterone hexanoate; 17α-Hydroxyprogesterone caproate; カプロン酸ヒドロキシプロゲステロン)

製品番号: HY-B0742 純度: 99.29%
COA 取扱説明書 Technical Support

Hydroxyprogesterone caproate (17α-Hydroxyprogesterone hexanoate; 17α-Hydroxyprogesterone caproate) is a progesterone receptor (progesterone receptor) ligand and steroid hormone transcription inhibitor. Hydroxyprogesterone caproate downregulates estrogen receptors in target tissues and activates their metabolic pathways, and exhibits equivalent affinity for progesterone receptor A and progesterone receptor B. Hydroxyprogesterone caproate shows no consistent teratogenicity or developmental toxicity in rat, mouse and monkey models, but induces resorption or abortion in rhesus monkeys at human-equivalent doses. Hydroxyprogesterone caproate promotes the production of TNF-α in lipopolysaccharide-stimulated whole blood from non-pregnant women. Hydroxyprogesterone caproate can be used in scientific research related to preterm birth.

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Hydroxyprogesterone caproate

Hydroxyprogesterone caproate 構造式

CAS 番号 : 630-56-8

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 60 在庫あり
Solution
10 mM * 1 mL in DMSO USD 60 在庫あり
Solid
500 mg $55 在庫あり
1 g $66 在庫あり
5 g $132 在庫あり
10 g   お問い合わせ  
50 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 6 publication(s) in Google Scholar

Other Forms of Hydroxyprogesterone caproate:

Hydroxyprogesterone caproate 関連抗体

Top Publications Citing Use of Products

  • 生物活性

  • 純度とドキュメンテーション

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製品説明

Hydroxyprogesterone caproate (17α-Hydroxyprogesterone hexanoate; 17α-Hydroxyprogesterone caproate) is a progesterone receptor (progesterone receptor) ligand and steroid hormone transcription inhibitor. Hydroxyprogesterone caproate downregulates estrogen receptors in target tissues and activates their metabolic pathways, and exhibits equivalent affinity for progesterone receptor A and progesterone receptor B. Hydroxyprogesterone caproate shows no consistent teratogenicity or developmental toxicity in rat, mouse and monkey models, but induces resorption or abortion in rhesus monkeys at human-equivalent doses. Hydroxyprogesterone caproate promotes the production of TNF-α in lipopolysaccharide-stimulated whole blood from non-pregnant women. Hydroxyprogesterone caproate can be used in scientific research related to preterm birth[1][2].

Cellular Effect
Cell Line Type Value Description References
Vero CC50
>50 μM
Compound: Hydroxyprogesterone caproate
Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr
Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr
10.1101/2020.03.20.999730
Vero IC50
6.3 μM
Compound: Hydroxyprogesterone caproate
Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr
Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr
10.1101/2020.03.20.999730
体外実験

Hydroxyprogesterone caproate (125-1250 ng/mL; 24 h simultaneous with LPS or 24 h total with 30 min pre-incubation) in whole blood from follicular-phase non-pregnant women, simultaneous treatment with 125 or 1250 ng/mL and LPS for 24 h significantly increases median TNF-α production to 2357 pg/mL and 2639 pg/mL, respectively, while 30 min pre-treatment with the same concentrations before LPS addition does not significantly alter TNF-α production relative to LPS alone[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hydroxyprogesterone caproate 関連抗体
体内実験

Hydroxyprogesterone caproate (5-150 mg/kg; i.m.; once on GD 8, 14, 20) administered at doses up to 150 mg/kg during the embryo-fetal ovarian development phase in Rattus norvegicus produces no consistent reproductive or developmental toxicity across F0, F1, and F2 generations, with a no-observable-effect-level (NOEL) established at 150 mg/kg[2].
Hydroxyprogesterone caproate (5-150 mg/kg; i.m.; once on GD 17) administered at doses up to 150 mg/kg post-testicular differentiation in Rattus norvegicus produces no consistent reproductive or developmental toxicity across F0, F1, and F2 generations, with a no-observable-effect-level (NOEL) established at 150 mg/kg[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley (CD [CRL:CD (SD)]) (time-mated females 8-10 weeks old at arrival; naïve males and females of same strain)[2]
Dosage: 5 mg/kg; 25 mg/kg; 150 mg/kg
Administration: i.m.; once on GD 17
Result: Reported all F0 dams survived to scheduled necropsy with no test-article-related clinical observations, body weight changes, or macroscopic necropsy findings; all dams delivered live offspring with no effects on gestational length, litter size, stillborn indices, or pup survival to weaning.
Found no test-article-related effects on F1 offspring's reflex, sensory, or developmental indices; an isolated statistically significant decrease in days to pinna detachment (25 mg/kg) was not considered toxicologically meaningful.
Observed no consistent adverse effects on F1 offspring's motor activity and learning/memory parameters, reproductive/fertility indices, or reproductive organ weights; isolated changes in seminal vesicle weight did not follow a dose-response pattern.
Detected no test-article-related effects on F2 generation's litter size, pup survival, sex ratios, or body weights; a statistically significant decrease in gestational length (150 mg/kg) was within the expected range for the strain and not considered biologically meaningful.
臨床実験
分子量

428.60

分子式

C27H40O4
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

CC([C@@]1(OC(CCCCC)=O)CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 25 mg/mL (58.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3332 mL 11.6659 mL 23.3318 mL
5 mM 0.4666 mL 2.3332 mL 4.6664 mL
10 mM 0.2333 mL 1.1666 mL 2.3332 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (5.83 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (5.83 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3332 mL 11.6659 mL 23.3318 mL 58.3294 mL
5 mM 0.4666 mL 2.3332 mL 4.6664 mL 11.6659 mL
10 mM 0.2333 mL 1.1666 mL 2.3332 mL 5.8329 mL
15 mM 0.1555 mL 0.7777 mL 1.5555 mL 3.8886 mL
20 mM 0.1167 mL 0.5833 mL 1.1666 mL 2.9165 mL
25 mM 0.0933 mL 0.4666 mL 0.9333 mL 2.3332 mL
30 mM 0.0778 mL 0.3889 mL 0.7777 mL 1.9443 mL
40 mM 0.0583 mL 0.2916 mL 0.5833 mL 1.4582 mL
50 mM 0.0467 mL 0.2333 mL 0.4666 mL 1.1666 mL
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Hydroxyprogesterone caproate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hydroxyprogesterone caproate630-56-817α-Hydroxyprogesterone hexanoate 17α-Hydroxyprogesterone caproateProgesterone ReceptorNR3C3micerhesus monkeysratsprogesterone receptorsteroid hormonesestrogen receptorspreterm birthcynomolgus monkeyssquirrel monkeystumor necrosis factor-alphaInhibitorinhibitorinhibit

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