Melanotan I  (Synonyms: MT-I; [Nle4,D-Phe7]-α-MSH)

Melanotan I is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I can be used for the research of sun-induced skin cancer, melanoma, inflammation and male erectile dysfunction^[1][2][3][4].

Melanotan I (1 μM, 72 h) does not alter or slightly inhibit the formation of tumor colonies, and inhibits melanoma cell proliferation in vitro^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Melanotan I (2 mg/kg/dayfor 12 weeks, s.c.) has no acute toxic effect in rodents^[2].
Melanotan I (2/10 mg/kg, s.c.) does not increase tumor incidence of human melanoma in SCID (immunodeficient) mice, nor does it lead to malignant transformation of tumors, and does not exhibit cancer-promoting effects. ^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1646.85

C₇₈H₁₁₁N₂₁O₁₉

75921-69-6

Solid

White to off-white

Ac-Ser-Tyr-Ser-{Nle}-Glu-His-{d-Phe}-Arg-Trp-Gly-Lys-Pro-Val-NH2

Ac-SYS-{Nle}-EH-{d-Phe}-RWGKPV-NH2

Room temperature in continental US; may vary elsewhere.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Langan EA, et al. Melanotropic peptides: more than just 'Barbie drugs' and 'sun-tan jabs'? Br J Dermatol. 2010 Sep;163(3):451-5.  [Content Brief]

  [2]. Mahiques-Santos L. Melanotan [Melanotan]. Actas Dermosifiliogr. 2012 May;103(4):257-9. Spanish.  [Content Brief]

  [3]. Hadley ME, et al. Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization. Peptides. 2006 Apr;27(4):921-30.  [Content Brief]

  [4]. Hadley ME, et al. Discovery and development of novel melanogenic drugs. Melanotan-I and -II. Pharm Biotechnol. 1998;11:575-95.  [Content Brief]