Melanotan I acetate
Based on 1 publication(s) in Google Scholar
Melanotan I (MT-I; [Nle4,D-Phe7]-α-MSH) acetate is an α-MSH (HY-P0252) analog, synthetic melanotropic peptide, and melanocortin receptor (MCR) agonist. Melanotan I acetate induces skin tanning by mimicking the action of α-MSH on the melanocortin 1 receptor (MC1R) in melanocytes. As an appetite suppressant, Melanotan I acetate impairs the ability of insulin to inhibit endogenous glucose production, suppresses leptin secretion from adipose tissue, and thereby reduces voluntary feed intake in ewes. Melanotan I acetate can be used in research related to UV-induced skin damage, polymorphic light eruption, ruminant feeding, and sexual dysfunction.
For research use only. We do not sell to patients.
- Purity: 98.96%
- CAS No.: 1566590-77-9
- Formula: C78H111N21O19.xC2H4O2
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Melanotan I acetate
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Biological Activity
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MC1R |
Melanotan I (1.0 μM) acetate does not enhance anchorage-independent clonogenic cell growth, a hallmark of malignancy, in freshly isolated human melanoma cell populations, with unaltered or slightly inhibited colony formation at 1.0 μM[2].
Melanotan I acetate inhibits proliferation of cultured human melanoma cell lines, demonstrating differentiating (melanogenic) activity[2].
Melanotan I acetate does not alter melanoma invasiveness in the human amniotic basement membrane model in vitro[2].
Melanotan I acetate stimulates cAMP production and subsequent eumelanin synthesis in cultured human melanocytes with some polymorphic MC1R variants[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Melanotan I acetate (10 μM; topical administration) does not induce skin papillomas in vjun transgenic mice, but causes local skin pigmentation[2].
Melanotan I acetate (4 mg; subcutaneous injection; single sustained-release injection) increases the eumelanin content in guinea pig skin by 2.5-fold, induces persistent pigmentation lasting up to 10 months, and shows no toxicity[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Suffolk ewes (3.5 yr old, body weight 84-96 kg, body condition score 3.3-4.0)[1]
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Dosage:0.0003 nmol/h; 0.003 nmol/h; 0.03 nmol/h
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Administration:i.c.v.; continuous; 24-82 h
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Result:Reduced voluntary dry matter intake by 50% (from 2,108 g DM/d to ~1,054 g DM/d) and energy intake from 1.8-fold maintenance to 1.1-fold maintenance; the appetite-suppressant effect was first detected 6-24 h after infusion initiation and sustained for 72 h.
Reduced dry matter intake by ~40% (from 2,170 g to 1,293 g) and energy intake from 1.8-fold maintenance to 1.01-fold maintenance; increased plasma triiodothyronine (T3) from 1.27 ng/mL to 1.60 ng/mL and plasma thyroxine (T4) from 5.50 ng/mL to 8.31 ng/mL in an intake-independent manner, with no effect on plasma glucose, insulin, cortisol, or free fatty acids.
Increased plasma T3, tended to reduce plasma leptin, had no effect on basal plasma glucose, fatty acids, insulin, or glucose entry rate, but blunted insulin-dependent suppression of endogenous glucose production during hyperinsulinemic-euglycemic clamps at both low and high insulin infusion rates.
Reduced plasma leptin with no effect on plasma adiponectin.
Chemical Information
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CAS No. 1566590-77-9
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Appearance Solid
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Formula C78H111N21O19.xC2H4O2
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Color White to off-white
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Synonyms
MT-I acetate; [Nle4,D-Phe7]-α-MSH acetate
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Sequence Shortening
Ac-SYS-{Nle}-EH-{d-Phe}-RWGKPV-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Theranostics
2020 Aug 13;10(24):11110-11126. PMID: 33042273
Solvent & Solubility
H2O : ≥ 50 mg/mL
* "≥" means soluble, but saturation unknown.
Purity & Documentation
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Data Sheet (278 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Melanotan I acetate Related Classifications
HY-N2466A Related Classifications
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