1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Mitiglinide calcium hydrate

Mitiglinide calcium hydrate (Synonyms: KAD-1229; S-21403)

Cat. No.: HY-B0682A
Handling Instructions

Mitiglinide calcium hydrate (KAD-1229), an insulinotropic agent, is an ATP-sensitive K+ (KATP) channel antagonist. Mitiglinide calcium hydrate is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide Calcium hydrate can be used for the research of type 2 diabetes.

For research use only. We do not sell to patients.

Mitiglinide calcium hydrate Chemical Structure

Mitiglinide calcium hydrate Chemical Structure

CAS No. : 207844-01-7

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Description

Mitiglinide calcium hydrate (KAD-1229), an insulinotropic agent, is an ATP-sensitive K+ (KATP) channel antagonist. Mitiglinide calcium hydrate is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide Calcium hydrate can be used for the research of type 2 diabetes[1][2].

IC50 & Target

KATP channel[1]

In Vitro

Mitiglinide calcium hydrate inhibits the Kir6.2/SUR1 channel currents in a dose-dependent manner (IC50 value, 100 nM) but does not significantly inhibit either Kir6.2/SUR2A or Kir6.2/SUR2B channel currents even at high doses (more than 10 μM) in COS-1 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Mitiglinide Calcium hydrate (1-3 mg/kg; p.o.) suppresses the increase in plasma glucose levels seen after a meal load and the area under the curve for plasma glucose levels (AUCglucose) up to 5 h after the meal load[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pregnant Wistar rats (12 weeks)[2]
Dosage: 0.3 mg/kg, 1 mg/kg, 3 mg/kg
Administration: Oral administration
Result: Dose-dependently suppressed AUCglucose levels.
Clinical Trial
Molecular Weight

352.46

Formula

C₁₉H₂₄NO₃.₁/₂Ca.H₂O

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Mitiglinide calcium hydrate
Cat. No.:
HY-B0682A
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