2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Mitiglinide calcium hydrate

Mitiglinide calcium hydrate  (Synonyms: KAD-1229; S-21403)

Cat. No.: HY-B0682A Purity: 99.90%
COA Handling Instructions

Mitiglinide calcium hydrate (KAD-1229), an insulinotropic agent, is an ATP-sensitive K+ (KATP) channel antagonist. Mitiglinide calcium hydrate is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide Calcium hydrate can be used for the research of type 2 diabetes.

For research use only. We do not sell to patients.

Mitiglinide calcium hydrate Chemical Structure

Mitiglinide calcium hydrate Chemical Structure

CAS No. : 207844-01-7

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Description

Mitiglinide calcium hydrate (KAD-1229), an insulinotropic agent, is an ATP-sensitive K+ (KATP) channel antagonist. Mitiglinide calcium hydrate is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide Calcium hydrate can be used for the research of type 2 diabetes[1][2].

IC50 & Target

KATP channel[1]
In Vitro

Mitiglinide calcium hydrate inhibits the Kir6.2/SUR1 channel currents in a dose-dependent manner (IC50 value, 100 nM) but does not significantly inhibit either Kir6.2/SUR2A or Kir6.2/SUR2B channel currents even at high doses (more than 10 μM) in COS-1 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Mitiglinide Calcium hydrate (1-3 mg/kg; p.o.) suppresses the increase in plasma glucose levels seen after a meal load and the area under the curve for plasma glucose levels (AUCglucose) up to 5 h after the meal load[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pregnant Wistar rats (12 weeks)[2]
Dosage: 0.3 mg/kg, 1 mg/kg, 3 mg/kg
Administration: Oral administration
Result: Dose-dependently suppressed AUCglucose levels.
Clinical Trial
Molecular Weight

352.46

Appearance

Solid

Formula

C19H24NO3.1/2Ca.H2O
CAS No.
SMILES

O=C(N1C[[email protected]@](CCCC2)([H])[[email protected]@]2([H])C1)C[[email protected]@H](C([O-])=O)CC3=CC=CC=C3.[0.5Ca2+].O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (70.93 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8372 mL 14.1860 mL 28.3720 mL
5 mM 0.5674 mL 2.8372 mL 5.6744 mL
10 mM 0.2837 mL 1.4186 mL 2.8372 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.09 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.09 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Mitiglinide calcium207844-01-7KAD-1229 S-21403KAD1229KAD 1229S21403S 21403S-21403Potassium ChannelKcsAhypoglycaemicinsulinotropictype2diabetesanti-diabeticInhibitorinhibitorinhibit

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