1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Mitiglinide

Mitiglinide (Synonyms: KAD-1229 free acid anhydrous; S21403 free acid anhydrous)

Cat. No.: HY-B0682
Handling Instructions

Mitiglinide (KAD-1229), an insulinotropic agent, is an ATP-sensitive K+ (KATP) channel antagonist. Mitiglinide is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide can be used for the research of type 2 diabetes.

For research use only. We do not sell to patients.

Mitiglinide Chemical Structure

Mitiglinide Chemical Structure

CAS No. : 145375-43-5

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other In-stock Forms of Mitiglinide:

Other Forms of Mitiglinide:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Mitiglinide (KAD-1229), an insulinotropic agent, is an ATP-sensitive K+ (KATP) channel antagonist. Mitiglinide is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide can be used for the research of type 2 diabetes[1][2].

IC50 & Target

KATP channel[1]

In Vitro

Mitiglinide inhibits the Kir6.2/SUR1 channel currents in a dose-dependent manner (IC50 of 100 nM) but does not significantly inhibit either Kir6.2/SUR2A or Kir6.2/SUR2B channel currents even at high doses (more than 10 μM) in COS-1 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Mitiglinide (1-3 mg/kg; p.o.) suppresses the increase in plasma glucose levels seen after a meal load and the area under the curve for plasma glucose levels (AUCglucose) up to 5 h after the meal load[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pregnant Wistar rats (12 weeks)[2]
Dosage: 0.3 mg/kg, 1 mg/kg, 3 mg/kg
Administration: Oral administration
Result: Dose-dependently suppressed AUCglucose levels.
Molecular Weight

315.41

Formula

C19H25NO3

CAS No.
SMILES

O=C(N1C[[email protected]@](CCCC2)([H])[[email protected]@]2([H])C1)C[[email protected]@H](C(O)=O)CC3=CC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Mitiglinide
Cat. No.:
HY-B0682
Quantity:
MCE Japan Authorized Agent: