1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Mitiglinide calcium

Mitiglinide calcium (Synonyms: KAD-1229 anhydrous; S21403 anhydrous)

Cat. No.: HY-17398 Purity: 98.7%
Handling Instructions

Mitiglinide Calcium (KAD-1229 anhydrous), an insulinotropic agent, is an ATP-sensitive K+ (KATP) channel antagonist. Mitiglinide Calcium is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide Calcium can be used for the research of type 2 diabetes.

For research use only. We do not sell to patients.

Mitiglinide calcium Chemical Structure

Mitiglinide calcium Chemical Structure

CAS No. : 145525-41-3

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Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 66 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
200 mg USD 84 In-stock
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500 mg USD 194 In-stock
Estimated Time of Arrival: December 31
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Description

Mitiglinide Calcium (KAD-1229 anhydrous), an insulinotropic agent, is an ATP-sensitive K+ (KATP) channel antagonist. Mitiglinide Calcium is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide Calcium can be used for the research of type 2 diabetes[1][2].

IC50 & Target

KATP channel[1]

In Vitro

Mitiglinide Calcium inhibits the Kir6.2/SUR1 channel currents in a dose-dependent manner (IC50 value, 100 nM) but does not significantly inhibit either Kir6.2/SUR2A or Kir6.2/SUR2B channel currents even at high doses (more than 10 μM) in COS-1 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Mitiglinide Calcium (1-3 mg/kg; p.o.) suppresses the increase in plasma glucose levels seen after a meal load and the area under the curve for plasma glucose levels (AUCglucose) up to 5 h after the meal load[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pregnant Wistar rats (12 weeks)[2]
Dosage: 0.3 mg/kg, 1 mg/kg, 3 mg/kg
Administration: Oral administration
Result: Dose-dependently suppressed AUCglucose levels.
Clinical Trial
Molecular Weight

334.44

Formula

C19H24NO3 . 1/2 Ca

CAS No.
SMILES

O=C([O-])[[email protected]](CC(N1C[[email protected]](CCCC2)([H])[[email protected]]2([H])C1)=O)CC3=CC=CC=C3.[0.5Ca2+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (14.95 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9901 mL 14.9504 mL 29.9007 mL
5 mM 0.5980 mL 2.9901 mL 5.9801 mL
10 mM 0.2990 mL 1.4950 mL 2.9901 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.5 mg/mL (1.50 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.5 mg/mL (1.50 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.5 mg/mL (1.50 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Product Name:
Mitiglinide calcium
Cat. No.:
HY-17398
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